Janux Therapeutics Shares Plunge 41% Despite 'Positive' Results from Cancer Drug Trial.
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 02 2025
0mins
Should l Buy NVS?
Source: Barron's
Company Overview: Janux Therapeutics is a biopharma company focused on developing treatments for cancer.
Trial Results: The company reported what it described as “positive trial data” for its novel treatment targeting late-stage prostate cancer patients.
Market Reaction: Despite the positive trial results, shares of Janux Therapeutics experienced a significant decline.
Investor Sentiment: The market's negative reaction raises questions about the interpretation of the trial data and its implications for the company's future.
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Analyst Views on NVS
Wall Street analysts forecast NVS stock price to fall
6 Analyst Rating
1 Buy
4 Hold
1 Sell
Hold
Current: 161.180
Low
112.00
Averages
127.75
High
143.00
Current: 161.180
Low
112.00
Averages
127.75
High
143.00
About NVS
Novartis AG is a Switzerland-based pharmaceutical company. The Company develops, manufactures, and markets branded and generic prescription drugs, active pharmaceutical ingredients (APIs), biosimilars and ophthalmic products. The Company uses science and digital technologies for treatments in the disease areas of immunology, dermatology, cancer, ophthalmology, neuroscience, respiratory, cardiovascular, renal and metabolism. The business activities of the Company are divided into two segments: Innovative Medicines, which includes innovative patent-protected prescription medicines for blood pressure, cancer and other ailments, and Sandoz, which includes generic pharmaceuticals and biosimilars.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Long-Term Follow-Up Advantage: The ALIGN study provides the longest follow-up period in pivotal Phase 3 studies for IgAN, ensuring a thorough assessment of Vanrafia's long-term effects, with safety consistent with previous findings, bolstering confidence in its market prospects.
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- Accelerated Approval Context: Vanrafia received accelerated approval from the FDA last April for proteinuria reduction in IgA nephropathy patients and has recently been granted similar approval in China, highlighting its global market potential.
- Market Performance: Novartis reported a core net income of $17.41 billion for full-year 2025, with earnings per share of $8.98, reflecting an increase from $15.76 billion and $7.81 per share in 2024, showcasing strong performance in drug development and sales.
- Future Plans: Novartis intends to seek traditional approval for Vanrafia this year, further solidifying its market position in kidney disease treatment and laying the groundwork for future revenue growth.
See More
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- Strong ETF Performance: The SPDR Portfolio Developed World ex-US ETF climbed over 30% in the past year, holding more than 2,300 developed-market stocks, positioning it prominently within the international recovery narrative while maintaining low fees.
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