Contineum Therapeutics Announces Encouraging Preliminary Results from PIPE-791 Phase 1b PET Study
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Sep 18 2025
0mins
Should l Buy CTNM?
Source: NASDAQ.COM
Positive Trial Results: Contineum Therapeutics, Inc. announced that its PIPE-791 Phase 1b trial met its primary endpoint, demonstrating high brain receptor occupancy in healthy volunteers and patients with progressive multiple sclerosis.
Safety Profile: The trial also confirmed that PIPE-791 has a safety and tolerability profile consistent with previous studies conducted by the company.
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Analyst Views on CTNM
Wall Street analysts forecast CTNM stock price to rise
7 Analyst Rating
6 Buy
1 Hold
0 Sell
Strong Buy
Current: 14.880
Low
14.00
Averages
18.60
High
22.00
Current: 14.880
Low
14.00
Averages
18.60
High
22.00
About CTNM
Contineum Therapeutics, Inc. is a clinical-stage biopharmaceutical company, which is engaged in developing novel, oral small molecule therapies for neuroscience, inflammation and immunology (NI&I) indications with significant unmet need. It is advancing a pipeline of internally developed programs with multiple drug candidates in clinical trials. Its lead asset, PIPE-791, is a novel, brain-penetrant, small-molecule inhibitor of the lysophosphatidic acid 1 receptor (LPA1R) in development for idiopathic pulmonary fibrosis (IPF), progressive multiple sclerosis (PrMS), and chronic pain. Its second drug candidate, PIPE-307, is a novel, small-molecule selective inhibitor of the muscarinic type 1 receptor (M1R), in development for depression and relapse-remitting multiple sclerosis (RRMS). The Company is also conducting preclinical and discovery-phase experiments targeting other NI&I indications where its internally discovered molecules may have therapeutic potential.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Additional Purchase Option: The company granted underwriters a 30-day option to purchase an additional 1,102,040 shares at the same price, further enhancing financial flexibility and potentially providing additional funding for future R&D projects.
- Expected Closing Date: The offering is expected to close on December 15, 2025, subject to customary closing conditions, and if successful, will provide crucial funding for the company's upcoming clinical trials and product development.
See More
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See More
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Market Reaction: The drop in share price indicates a negative market reaction to recent developments concerning the company.
See More
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- Operating Expense Improvement: The company also lowered its projected GAAP operating expenses for 2025 by $200 million, demonstrating improved cost control capabilities that lay a solid foundation for future profitability.
- Increased Cash Balance: Moderna anticipates an end-of-year cash balance of approximately $8.1 billion, providing strong support for the company's R&D and market expansion efforts, further solidifying its market position.
- Strong Stock Performance: Following the positive news, Moderna's stock surged 12.8% to $38.20 on Tuesday, reflecting market optimism regarding its future growth potential.
See More
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- Upsized Offering: Contineum Therapeutics has announced an upsized public offering of 7,346,938 shares of Class A common stock priced at $12.25 per share, expected to raise approximately $90 million, thereby strengthening the company's financial position to support its clinical-stage biopharmaceutical development.
- Underwriter Selection: The offering is being managed by Goldman Sachs, Leerink Partners, Stifel, RBC Capital Markets, and William Blair, reflecting market confidence in Contineum and potentially enhancing its market position in the biopharmaceutical sector.
- Additional Purchase Option: The company has granted underwriters a 30-day option to purchase up to an additional 1,102,040 shares at the same price, further enhancing financial flexibility and potentially providing additional funding for future research and development projects.
- Expected Closing Date: The offering is anticipated to close on December 15, 2025, subject to customary closing conditions, which will provide the company with much-needed capital to advance its innovative therapies targeting neuroscience, inflammation, and immunology indications.
See More
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- Upsized Offering: Contineum Therapeutics announced the pricing of an upsized public offering of 7,346,938 shares of Class A common stock at $12.25 per share, raising approximately $90 million, which will enhance the company's financial capacity to support its R&D in biopharmaceuticals.
- Underwriter Selection: The offering is managed by Goldman Sachs, Leerink Partners, Stifel, RBC Capital Markets, and William Blair, reflecting strong market confidence in the company's future and potentially attracting more investor interest.
- Additional Purchase Option: The company granted underwriters a 30-day option to purchase an additional 1,102,040 shares at the same price, further enhancing financial flexibility and potentially providing additional funding for future R&D projects.
- Expected Closing Date: The offering is expected to close on December 15, 2025, subject to customary closing conditions, and if successful, will provide crucial funding for the company's upcoming clinical trials and product development.
See More
Contineum Therapeutics Launches $75 Million Public Offering
- Offering Announcement: Contineum Therapeutics has initiated a public offering of $75 million aimed at funding its research in neuroscience, inflammation, and immunology, thereby enhancing its competitive position in the market.
- Underwriter Option: The company intends to grant underwriters a 30-day option to purchase an additional $11.25 million in shares, which will further bolster its financing capabilities and support future R&D efforts.
- Strong Underwriter Lineup: The involvement of Goldman Sachs, Leerink Partners, Stifel, RBC Capital Markets, and William Blair as joint book-running managers demonstrates significant market confidence and support for the company.
- Market Uncertainty: The completion timing and size of the offering remain uncertain, reflecting the volatility of market conditions that could impact the company's future cash flow and project timelines.
See More
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Stock Performance: Contineum Therapeutics (CTNM) shares experienced a decline of approximately 10% during recent trading on Friday.
Market Reaction: The drop in share price indicates a negative market reaction to recent developments concerning the company.
See More
Contineum Therapeutics' Multiple Sclerosis Trial Falls Short, Yet Analyst Believes Other Assets Will Enhance Value
Trial Results: Contineum Therapeutics announced that its Phase 2 VISTA trial of PIPE-307 for relapsing-remitting multiple sclerosis did not meet its primary or secondary efficacy endpoints, despite showing acceptable safety and tolerability.
Future Plans: The company plans to present the complete dataset at a future medical meeting and publish the full results in a peer-reviewed journal, while continuing to analyze exploratory endpoints.
Market Reaction: Following the trial results, RBC Capital Markets lowered the price forecast for CTNM stock from $25 to $22, maintaining an Outperform rating but highlighting the high-risk nature of the trial.
Financial Outlook: Contineum has extended its cash runway to fund operations through 2028, deferring the initiation of other clinical development efforts while focusing on PIPE-791 for idiopathic pulmonary fibrosis.
See More
