Can-Fite Advances Namodenoson Clinical Trials, Interim Data Expected Q4 2026
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 16 2025
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Should l Buy CANF?
Source: Newsfilter
- Clinical Trial Progress: Can-Fite is conducting a pivotal Phase III clinical trial for Namodenoson targeting advanced hepatocellular carcinoma in Child-Pugh B7 patients, with interim analysis data expected in Q4 2026, which may lead to conditional regulatory approval from the FDA and EMA if results are positive.
- Multiple Research Initiatives: Concurrently, Namodenoson is also in a Phase IIb clinical trial for metabolic dysfunction-associated steatohepatitis, following positive Phase IIa results that demonstrated anti-inflammatory, anti-steatotic, and anti-fibrotic effects, thereby expanding its therapeutic indications.
- Strong Financial Position: As of June 30, 2025, Can-Fite reported $6.45 million in cash and cash equivalents, having completed a public offering for $5 million in July 2025, ensuring funding for ongoing clinical research.
- Clear Strategic Focus: CEO Motti Farbstein emphasized the company's commitment to addressing significant unmet medical needs, with ongoing Phase III studies in liver cancer and psoriasis expected to yield meaningful clinical data, further solidifying its market position in the biopharmaceutical sector.
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Analyst Views on CANF
About CANF
Can Fite Biopharma Ltd is an Israel-based clinical-stage biopharmaceutical company engaged in developing orally bioavailable small molecule therapeutic products for the treatment of cancer, liver and inflammatory diseases and erectile dysfunction. The Company co-develop formulations of cannabis components for the treatment of cancer, inflammatory, autoimmune, and metabolic diseases. Its technology utilizes the Gi protein associated A3AR as a therapeutic target. A3AR is expressed in inflammatory and cancer cells, and not significantly expressed in normal cells, suggesting that the receptor could be a target for pharmacological intervention.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Clinical Program Support: This patent reflects the company's broader clinical and preclinical programs, which are expected to pave the way for future partnering or commercialization opportunities in Latin America, further driving business growth.
- Market Reaction: Can-Fite's stock is trading at $0.24 in pre-market hours on the NYSE American, down 1.94% from the previous trading day, indicating a cautious market response to the news.
- Strategic Implications: Securing this patent not only provides Can-Fite with a competitive edge but may also attract potential investors and partners, helping the company establish a foothold in the rapidly evolving biopharmaceutical sector.
See More
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- Market Potential: Brazil, being one of the largest pharmaceutical markets in Latin America, presents significant business expansion opportunities for Can-Fite as demand for innovative sexual health therapies continues to grow.
- Therapeutic Mechanism Validation: Clinical and preclinical data from Can-Fite suggest that activation of the A3 adenosine receptor may modulate key signaling mechanisms related to erectile and sexual function, supporting the therapeutic rationale behind the patent.
- Strategic Opportunities: The patent not only validates the therapeutic versatility of A3 adenosine receptor agonists but also may create future partnering or commercialization opportunities for Can-Fite in Latin America.
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- Market Potential: As one of the largest pharmaceutical markets in Latin America, Brazil's growing demand for innovative therapies in sexual health can be addressed by Can-Fite's patent, enhancing the company's competitive edge in this sector.
- Clinical Data Support: Preclinical and clinical data from Can-Fite suggest that activation of the A3 adenosine receptor may modulate key signaling mechanisms related to erectile and sexual function, supporting the therapeutic rationale for the patent and potentially paving the way for future commercialization opportunities.
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