Autolus Presents CARLYSLE Trial Preliminary Data Showing Significant B-Cell Depletion Improvement
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 08 2025
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Should l Buy AUTL?
Source: Newsfilter
- Clinical Trial Progress: Autolus presented preliminary data from the CARLYSLE trial at the American Society of Hematology meeting, indicating significant improvement in three patients dosed with 100 million cells, highlighting the therapy's potential in treating severe refractory systemic lupus erythematosus (srSLE).
- Safety Assessment: In the 50 million dose cohort, no dose-limiting toxicities (DLTs) or high-grade cytokine release syndrome (CRS) were observed in any patients, indicating a favorable safety profile for obe-cel and laying the groundwork for future clinical applications.
- Efficacy Metrics: In the 50 million dose group, 50% of patients achieved complete response rates (CRR) and 83% achieved deep responses, with no new disease activity observed during a 12-month follow-up, demonstrating the therapy's long-term efficacy.
- Future Trial Plans: Following the positive initial results from the CARLYSLE trial, Autolus has initiated the LUMINA trial aimed at further validating the registrational intent of obe-cel in lupus nephritis, showcasing the company's strategic positioning in the autoimmune disease sector.
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Analyst Views on AUTL
Wall Street analysts forecast AUTL stock price to rise
5 Analyst Rating
5 Buy
0 Hold
0 Sell
Strong Buy
Current: 1.380
Low
5.00
Averages
7.68
High
10.00
Current: 1.380
Low
5.00
Averages
7.68
High
10.00
About AUTL
Autolus Therapeutics plc is a United Kingdom-based early commercial-stage biopharmaceutical company developing programmed T cell therapies for the treatment of cancer and autoimmune diseases. The Company has an approved commercial product, AUCATZYL, for the treatment of adult patients with r/r B-ALL. Using a suite of proprietary and modular T cell programming technologies, it is also developing five programs in seven hematological and solid tumor indications and one autoimmune indication. It is engineering precisely targeted, controlled and highly active T cell therapies that are designed to better recognize target cells, break down their defense mechanisms and attack and eliminate these cells. Its product pipeline includes obe-cel (ALLCAR19), obe-cel (CAROUSEL), AUTO1/22 (CARPALL), AUTO4 (LibrA T1), AUTO6 (MAGNETO), AUTO5, AUTO8 (MCARTY) and AUTO9. AUTO4 and AUTO5 are two programmed T cell therapies for the treatment of peripheral T-cell lymphoma targeting TRBC 1 and TRBC 2.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Enhanced Market Competitiveness: By improving product bioavailability, Gelteq not only meets the growing consumer demand but also positions itself more favorably in the competitive pharmaceutical market, potentially driving the company's long-term strategic development.
- Increased Investor Interest: With Gelteq's technological advancements and stock price increase, market attention on its future performance has significantly risen, likely attracting more investors and partners, thereby facilitating the company's capital operations and business expansion.
See More
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- High-Throughput Production: Cellares' platform can process up to 16 patient batches simultaneously, delivering up to 10-fold higher throughput than conventional cell therapy manufacturing facilities, potentially significantly enhancing Autolus' market competitiveness.
- Exploration of New Indications: Autolus is assessing its AUCATZYL® therapy for indications beyond acute lymphoblastic leukemia, and successful expansion could lead to increased demand for manufacturing capacity.
- Strategic Partnership Outlook: The integration of Cellares' technology with Autolus' existing manufacturing foundation may provide a capital-efficient solution for future expansion, addressing the growing patient demand.
See More
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