Autolus Presents CARLYSLE Trial Preliminary Data Showing Significant B-Cell Depletion
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 08 2025
0mins
Should l Buy AUTL?
Source: Globenewswire
- Clinical Trial Progress: Autolus presented preliminary data from the CARLYSLE trial at the American Society of Hematology Annual Meeting, showing significant B-cell depletion in both 50M and 100M dose cohorts, indicating a potential immune reset that addresses the urgent needs of patients with severe refractory systemic lupus erythematosus.
- Efficacy Assessment: In the 50M dose cohort, 50% of patients achieved complete response rates (CRR) and 83% achieved deep responses (DORIS), establishing a solid foundation for the upcoming LUMINA trial, which is expected to further propel the clinical application of obe-cel.
- Safety Analysis: Among the nine evaluable patients, no dose-limiting toxicities (DLTs) or high-grade cytokine release syndrome (CRS) were observed, indicating a favorable safety profile for obe-cel in treating severe refractory systemic lupus erythematosus, potentially enhancing market confidence.
- Future Outlook: Following these positive initial results, Autolus has aligned with the FDA to initiate the LUMINA trial aimed at lupus nephritis with registrational intent, further expanding the indications for obe-cel and enhancing the company's market position in autoimmune diseases.
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Analyst Views on AUTL
Wall Street analysts forecast AUTL stock price to rise
5 Analyst Rating
5 Buy
0 Hold
0 Sell
Strong Buy
Current: 1.380
Low
5.00
Averages
7.68
High
10.00
Current: 1.380
Low
5.00
Averages
7.68
High
10.00
About AUTL
Autolus Therapeutics plc is a United Kingdom-based early commercial-stage biopharmaceutical company developing programmed T cell therapies for the treatment of cancer and autoimmune diseases. The Company has an approved commercial product, AUCATZYL, for the treatment of adult patients with r/r B-ALL. Using a suite of proprietary and modular T cell programming technologies, it is also developing five programs in seven hematological and solid tumor indications and one autoimmune indication. It is engineering precisely targeted, controlled and highly active T cell therapies that are designed to better recognize target cells, break down their defense mechanisms and attack and eliminate these cells. Its product pipeline includes obe-cel (ALLCAR19), obe-cel (CAROUSEL), AUTO1/22 (CARPALL), AUTO4 (LibrA T1), AUTO6 (MAGNETO), AUTO5, AUTO8 (MCARTY) and AUTO9. AUTO4 and AUTO5 are two programmed T cell therapies for the treatment of peripheral T-cell lymphoma targeting TRBC 1 and TRBC 2.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Enhanced Market Competitiveness: By improving product bioavailability, Gelteq not only meets the growing consumer demand but also positions itself more favorably in the competitive pharmaceutical market, potentially driving the company's long-term strategic development.
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See More
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- High-Throughput Production: Cellares' platform can process up to 16 patient batches simultaneously, delivering up to 10-fold higher throughput than conventional cell therapy manufacturing facilities, potentially significantly enhancing Autolus' market competitiveness.
- Exploration of New Indications: Autolus is assessing its AUCATZYL® therapy for indications beyond acute lymphoblastic leukemia, and successful expansion could lead to increased demand for manufacturing capacity.
- Strategic Partnership Outlook: The integration of Cellares' technology with Autolus' existing manufacturing foundation may provide a capital-efficient solution for future expansion, addressing the growing patient demand.
See More
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