SYRE News & Events

Spyre Therapeutics announced the completion of recruitment for the RA sub-study of the SKYWAY basket trial and acceleration of expected topline readout to Q3 2026. "Enrollment in the RA sub-study of SKYWAY has exceeded our expectations and reflects both substantial unmet need as well as investigator enthusiasm for the potential of a long-acting anti-TL1A antibody," said Joshua Friedman, M.D., Ph.D., SVP of Clinical Development and SKYWAY study lead. "We look forward to delivering the first proof-of-concept data for this mechanism in rheumatic disease in the third quarter, with the potential to advance to pivotal trials next year. Together with readouts from the SKYLINE study, we now expect key data from Spyre's programs in IBD and rheumatic diseases in every subsequent quarter this year."

Spyre Therapeutics is up 11.2%, or $4.25 to $42.06.

Reports Q4 R&D expenses totaled $44.6M for the quarter, a decrease driven primarily by lower early-stage R&D activities, and the company reported ending the year with $756.5M in cash, cash equivalents, and marketable securities. "This year is a pivotal period for Spyre as we begin to unveil results from our two groundbreaking Phase 2 trials with the potential to identify multiple products that leapfrog today's standard of care and provide substantially improved therapies for patients suffering from severe autoimmune diseases," said CEO Cameron Turtle.