SPRO Forecast — Price Prediction for 2025. Should I Buy SPRO?

1-Day-Price-Prediction

-4.31%

1-Week Prediction

+0.49%

1-Month Prediction

+2.9%

2026 Prediction

-100%

2030 Prediction

-100%

Based on our advanced algorithm, we have generated comprehensiveSPRO stock price predictions for multiple time horizons. Our models indicate potential volatility in the short term, with specific targets calculated for the 1-day and 1-week outlooks.

Looking further ahead, our analysts have pinpointed significant trend shifts in the longer-term data. We have exclusive projections available for the 1-month forecast, a detailed 2026 projection, and a long-range 2030 forecast that reveals potential upside or downside risks.

Unlock the full analysis to access these precise price targets and see exactly where our models predict SPRO is heading. Stay informed and make strategic decisions with our premium data-driven insights!

Should I Buy Spero Therapeutics Inc Stock?

Based on our evaluation of the five key dimensions—Technical Signals, Moving Average trends, Short Sell Data, Similar Chart Pattern Matching and Seasonality Analysis—we have identified the following insights. SPRO has several positive signals and is within a rising trend, so we believe it will perform strongly in the next couple of days or weeks. We therefore hold a positive evaluation of this stock. Our analysis conclusion for this stock is a Strong Buy candidate.

SPRO stock price ended at $2.57 on Thursday, after losing -1.15%

The Spero Therapeutics Inc stock price decreased by -1.15% on the last trading day (08 Jan 2026), dropping from 2.59 to 2.57. Throughout the last trading session, the stock experienced a fluctuation of 3.59% , ranging from a day low of $2.51 to a day high of 2.6. The price has declined in 4 of the last 10 days, resulting in a total change of 10.30% during this period. On the last day, trading volume decrease by -37.55K shares, with the falling prices. This could serve as an early warning, indicating that risk may slightly increase in the coming days. In total, 284.65K shares were traded, amounting to approximately 720.24K.

SPRO Technical Signals

SPRO(Spero Therapeutics Inc Corp) has 4 buy signals and 3 sell signals now. The current trend is an uptrend starting from 2025-12-03. The total price change during this trend is +12.72%. Recently, the price has dropped while volume droped, indicating a potential rebound signal. The average turnover of SPRO over the last 5 trading days is 720.29K. Overall, the technical indicator signals lean more toward a Neutral outlook in the mid-term.

SPRO Moving Average Analysis

Spero Therapeutics Inc's overall moving average trend leans more bullish as of Friday, January 9, 2026, with 0 negative signals and 4 positive signal. In the mid-term, the SMA_20 being above the SMA_60 signals a strong bullish trend. There will be some resistance from the lines at $2.68, and $2.83. A break-up above any of these levels will issue buy signals. There will be some support from the lines at $2.20, and $2.06. A break-down below any of these levels will issue sell signals.

SPRO Short Selling Analysis

The short sale ratio of Spero Therapeutics Inc(SPRO) as of 10 Dec 2025 is 6.42%, dropping from last trading day. With decreasing price from 2.33 to 2.33.

Technical Signal

Technical Signals Summary

Sell

Buy

Moving Average

Swing

Positive

Stock Price Above SMA_5

Short Term

Positive

SMA_5 Above SMA_20

Mid Term

Positive

SMA_20 Above SMA_60

Long Term

Positive

SMA_60 Above SMA_200

Short Selling

Close Price

Short Sale Ratio

Short Sale Volume

4 Bullish Signals

When Value satisfies Signal, Indicator signals Bullish

Indicators

Signal

Value

Meaning

Awesome Oscillator (5, 34)

AO_5_34 > 0

0.131

Bullish

Momentum (10 days)

MOM_10 > 0

0.24

Bullish

Moving Average Convergence Divergence (12, 26, 9)

MACD_12_26_9 > 0

0.0483

Bullish

Moving Average

20-day SMA crosses above 60-day SMA

Bullish

3 Bearish Signals

When Value satisfies Signal, Indicator signals Bearish

Indicators

Signal

Value

Meaning

Stochastic Oscillator %K (14, 3, 3)

STOCHk_14_3_3 > 80

86.621

Bearish

Commodity Channel Index (20 days, 0.015 constant)

CCI_20_0.015 > 100

218.795

Bearish

Stochastic RSI %K (14, 14, 3, 3)

STOCHRSIk_14_14_3_3 > 80

95.582

Bearish

SPRO Stock Forecast

2026

2027

2028

2029

2030

2031

2032

2033

2034

2035

Month	Min. Price	Avg. Price	Max. Price	Potential ROI

In 2026, Spero Therapeutics Inc (SPRO) is anticipated to change hands in a trading channel between $0.00 and $0.00.

Spero Therapeutics Inc Stock Forecast 2026

SPRO Price Prediction & Forecast by Similar Chart Analysis

Based on historical patterns and backtesting of stocks with similar movements to Spero Therapeutics Inc(SPRO), our algorithm predicts SPRO's 1-month price at $2.49, with an 7.2%upwardshift. Using a similarity score up to 92.73%and other factors, This forecast updates weekly, adjusting for significant deviations.

Similar Chart

The price prediction chart for Spero Therapeutics Inc (SPRO.O) stock, as of Sunday, December 21, 2025 , forecasts a 7.2% change over the next month, based on its high correlation with RDY.N stock patterns. The similarity between their price movements over the analyzed periods is 92.73%. The right panel lists other stocks with similar price patterns. This prediction is updated every week.

SPRO

No data

RDY

Up: 7.2%Similarity: 92.73%

Name

Similarity

Up/Down

RDY.N

92.73%

+7.20%

SFL.N

92.62%

+5.20%

ODFL.O

92.43%

-1.94%

ADTN.O

92.33%

-3.21%

ATPC.O

92.32%

-22.44%

HNNA.O

92.28%

-12.07%

DC.A

92.22%

+3.12%

TEN.N

92.00%

-21.93%

GCT.O

91.97%

+1.52%

ATXG.O

91.93%

-0.11%

SPRO Seasonality Analysis

Based on SPRO's historical stock price data across all years, the probability of a positive return in January is55.56%, suggesting it maybe an ideal month to invest in SPRO. In contrast,Novemberoffers the highest probability of positive returns at62.50%, making it a potentially strong month for investment.

However, this is only a prediction based on one method, and a comprehensive assessment of the stock's future trend should consider additional factors. Our final stock price commentary incorporates three main evaluation dimensions: technical signals, Moving Average trends, and similar chart pattern matching, with the first two dimensions carrying the primary weight to ensure a more robust and accurate forecast.

Monthly Seasonality

The radar chart shows that buying Spero Therapeutics Inc (SPRO.O) stock in November has the highest probability of a positive return (62.50%), while July has the lowest probability (25.00%).

Performance Seasonality

The chart shows Spero Therapeutics Inc. (SPRO)'s annual stock price return for the past three years, helping you analyze price trends and identify recurring trends on an annual basis.

People Also Watch

Frequently Asked Questions

Should I buy Spero Therapeutics Inc (SPRO.O) stock?

Which months have the highest win rate for buying Spero Therapeutics Inc (SPRO.O) stock in a year?

The radar chart shows that buying Spero Therapeutics Inc (SPRO.O) stock in November has the highest probability of a positive return (62.50%), while July has the lowest probability (25.00%).

How has Spero Therapeutics Inc. (SPRO)'s stock price performed over the past three years?

SPRO's stock price fell by -32.24% in 2024,increased by 115.74% in 2025, and went up by 9.36%in 2026.

Which bullish technical signals does SPRO have?

Bullish technical signals of SPRO include: AO_5_34 > 0, MOM_10 > 0, MACD_12_26_9 > 0, 20-day SMA crosses above 60-day SMA.

Which bearish technical signals does SPRO have?

Bearish technical signals of SPRO include: STOCHk_14_3_3 > 80, CCI_20_0.015 > 100, STOCHRSIk_14_14_3_3 > 80.

Is SPRO a buy based on overall technical signals summary?

SPRO has 4 buy signals and 3 sell signals now. Overall the technical rating for SPRO is Neutral . Note that market conditions change all the time. In addition to technical ratings, keep an eye on the Valuation Level of SPRO.

What is the trend of Spero Therapeutics Inc (SPRO)'s moving average?

Spero Therapeutics Inc's overall moving average trend leans more bullish as of January 09 2026, with 0 negative signals and 4 positive signal.

What is price prediction for SPRO stock next month?

The price prediction chart for Spero Therapeutics Inc (SPRO.O) stock, as of December 21 2025, forecasts a 7.2% change over the next month, based on its high correlation with RDY stock patterns. The similarity between their price movements over the analyzed periods is 92.73%. The right panel lists other stocks with similar price patterns. This prediction is updated every week.

What is price prediction 2026 for Spero Therapeutics Inc (SPRO) Stock?

In , Spero Therapeutics Inc's value is forecasted to reach an average price of $NaN. The price is predicted to fluctuate between a low of $NaN and a high of $NaN.

What is price prediction 2030 for Spero Therapeutics Inc (SPRO) Stock?

In , Spero Therapeutics Inc's value is forecasted to reach an average price of $NaN. The price is predicted to fluctuate between a low of $NaN and a high of $NaN.

SPRO Stock Price Prediction

SPRO Stock Price Prediction

Should I Buy Spero Therapeutics Inc Stock?

SPRO stock price ended at $2.57 on Thursday, after losing -1.15%

SPRO Technical Signals

SPRO Moving Average Analysis

SPRO Short Selling Analysis

Technical Signal

Technical Signals Summary

Moving Average

Short Selling

SPRO Stock Forecast

SPRO Price Prediction & Forecast by Similar Chart Analysis

No data

SPRO Seasonality Analysis

Monthly Seasonality

Performance Seasonality

People Also Watch

Frequently Asked Questions

Should I buy Spero Therapeutics Inc (SPRO.O) stock?

Which months have the highest win rate for buying Spero Therapeutics Inc (SPRO.O) stock in a year?

How has Spero Therapeutics Inc. (SPRO)'s stock price performed over the past three years?

Which bullish technical signals does SPRO have?

Which bearish technical signals does SPRO have?

Is SPRO a buy based on overall technical signals summary?

What is the trend of Spero Therapeutics Inc (SPRO)'s moving average?

What is price prediction for SPRO stock next month?

What is price prediction 2026 for Spero Therapeutics Inc (SPRO) Stock?

What is price prediction 2030 for Spero Therapeutics Inc (SPRO) Stock?