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BCYC Overview

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ET
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ET
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Intellectia

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High
5.290
Open
5.110
VWAP
5.13
Vol
827.51K
Mkt Cap
351.70M
Low
5.020
Amount
4.24M
EV/EBITDA(TTM)
--
Total Shares
69.37M
EV
-297.08M
EV/OCF(TTM)
--
P/S(TTM)
12.34
Bicycle Therapeutics plc is a United Kingdom-based clinical-stage biopharmaceutical company developing a class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. The Company is evaluating zelenectide pevedotin, a Bicycle Toxin Conjugate (BTC) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target, and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist (Bicycle TICA) targeting Nectin-4 and agonizing CD137, in Company-sponsored clinical trials. Additionally, the Company is developing Bicycle Radio Conjugates (BRC) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology to develop therapies for diseases beyond oncology.
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Events Timeline

(ET)
2026-03-17
07:10:00
Bicycle Therapeutics Q4 Revenue $47.96M, Exceeds Expectations
select
2026-02-03 (ET)
2026-02-03
07:30:00
Michael Method Promoted to Chief Medical Officer at Bicycle
select
2026-02-03
07:30:00
Bicycle Appoints Michael Skynner as Chief Scientific Officer
select
2026-02-03
07:30:00
Bicycle Therapeutics Appoints New CFO
select
2025-12-16 (ET)
2025-12-16
05:20:00
Bicycle Therapeutics Signs 15-Year Contract with UK Nuclear Decommissioning Authority
select

News

seekingalpha
9.5
12:11 PMseekingalpha
PinnedBicycle Therapeutics Q4 Earnings Exceed Expectations
  • Strong Earnings Report: Bicycle Therapeutics reported a Q4 GAAP EPS of -$0.29, beating expectations by $0.66, indicating a significant improvement in financial performance and reflecting the potential value of its business model.
  • Revenue Surge: The company achieved Q4 revenue of $47.96 million, a staggering 1192.7% year-over-year increase, surpassing market expectations by $40.88 million, demonstrating robust demand and rapid growth for its products or services.
  • Healthy Cash Position: As of December 31, 2025, Bicycle Therapeutics holds $628 million in cash and cash equivalents, with an expected cash runway extending into 2030, enhancing the company's flexibility for future investments and operations.
  • Strategic Restructuring Plan: The company plans to reduce its workforce by approximately 30% to optimize resource allocation and improve operational efficiency, a move that not only helps lower costs but may also enhance the company's long-term sustainability in the competitive biopharmaceutical industry.
seekingalpha
4.5
20:12 PMseekingalpha
Bicycle Therapeutics Restructures and Lays Off 30% of Workforce
  • Strategic Restructuring: Bicycle Therapeutics announced a reprioritization of certain programs and a layoff of approximately 30% of its workforce to focus on its most promising candidates, resulting in an expected 50% reduction in annual operating expenses.
  • Pipeline Focus: The company will concentrate its research efforts on BT5528 (also known as nuzefatide pevedotin), a potentially first-in-class EphA2-targeting drug conjugate currently in phase I/II clinical trials, aimed at treating metastatic pancreatic ductal adenocarcinoma, indicating strong market potential.
  • Clinical Trial Progress: BT5528 is being tested as a monotherapy and in combination with an immune checkpoint inhibitor in phase I/II trials, while also undergoing a phase II trial as a monotherapy for metastatic pancreatic ductal adenocarcinoma, showcasing its potential in cancer treatment.
  • Asset De-prioritization: Bicycle Therapeutics will deprioritize its most advanced drug conjugate, zelenectide pevedotin, which targets Nectin-4 expressing tumors and was previously in a phase II trial for metastatic urothelial cancer, reflecting the company's strategic resource allocation adjustments.
seekingalpha
5.0
02-03seekingalpha
Bicycle Therapeutics Appoints New CFO
  • Executive Changes: Bicycle Therapeutics has appointed Travis Thompson as the new Chief Financial Officer, who previously served as the company's Senior Vice President and Chief Accounting Officer, continuing to oversee finance and accounting functions while taking on investor relations, which is expected to enhance communication efficiency with investors.
  • Interim Transition Plan: Former CFO Alethia Young will remain in an interim capacity for the next three months before transitioning to a company advisor role, a move designed to ensure continuity and stability in financial management while mitigating potential risks associated with executive turnover.
  • Medical and Technology Leadership Adjustments: The company has also promoted Michael Method to Chief Medical Officer, while Michael Skynner, Ph.D., is transitioning to Chief Scientific Officer, which will strengthen the company's leadership in research and development and drive innovation.
  • Strategic Restructuring: These executive changes reflect Bicycle Therapeutics' strategic emphasis on enhancing financial, medical, and technological management, aiming to support the company's long-term growth objectives through an optimized leadership team.
Businesswire
7.5
2025-12-16Businesswire
Bicycle Therapeutics Signs 15-Year Contract with UK NDA for 400 Tonnes of Reprocessed Uranium
  • Strategic Partnership: Bicycle Therapeutics has signed a 15-year contract with the UK Nuclear Decommissioning Authority to access up to 400 tonnes of reprocessed uranium, which is expected to provide a sustainable supply of 212Pb for its potential lifesaving therapies, significantly enhancing its competitive edge in the radiopharmaceutical sector.
  • Technological Innovation: Through collaboration with the UK National Nuclear Laboratory, Bicycle plans to extract 228Th from the reprocessed uranium and further process it into 224Ra, developing a bespoke 212Pb generator that will drive the development of its radioconjugate portfolio.
  • Market Potential: Bicycle's radioconjugates (BRCs) will utilize 212Pb as a potent therapeutic payload against cancer, expected to offer new treatment options for cancer patients worldwide, presenting significant market opportunities and societal impact.
  • R&D Progress: Bicycle aims to present initial EphA2 human imaging data in the first half of 2026 and initiate its own clinical study, marking ongoing advancements in radiopharmaceutical development and establishing its position as a potential leader in the field.
Newsfilter
7.5
2025-12-16Newsfilter
Bicycle Therapeutics Signs 15-Year Contract with UK NDA for 400 Tonnes of Reprocessed Uranium
  • Long-Term Partnership: Bicycle Therapeutics has signed a 15-year contract with the UK Nuclear Decommissioning Authority, securing access to up to 400 tonnes of reprocessed uranium, which will provide a sustainable raw material supply for its potential lifesaving therapies, significantly enhancing the company's R&D capabilities.
  • Radioisotope Development: Through collaboration with the UK National Nuclear Laboratory, Bicycle plans to extract 228Th from the reprocessed uranium, further processing it into a 212Pb generator, with the potential to deliver tens of thousands of doses of 212Pb annually, advancing targeted cancer therapies.
  • Customized Generator: Bicycle has partnered with SpectronRx to develop a bespoke 212Pb generator, with initial quantities of 212Pb successfully produced, which will provide strong support for the company's competitive position in the radiopharmaceutical market.
  • Strategic Investment Outlook: The CEO of Bicycle stated that these collaborations demonstrate the company's potential in radiopharmaceutical R&D, with expectations to advance its BRC product line and present initial human imaging data in the first half of 2026, further solidifying its market position.
PRnewswire
7.0
2025-12-11PRnewswire
Bicycle Therapeutics Under Investigation, ADR Price Drops 7.88%
  • Securities Fraud Investigation: Pomerantz LLP is investigating whether Bicycle Therapeutics plc has engaged in securities fraud or other unlawful business practices, which could undermine investor confidence and lead to stock price volatility.
  • Analyst Downgrade: RBC Capital Markets analyst Leonid Timashev downgraded Bicycle from Outperform to Sector Perform, citing delays in dose selection for its drug in phase 2/3 development for metastatic urothelial cancer, pushing timelines to Q1 2026, which threatens its competitive position in a growing market.
  • Increased Competition Impact: Timashev noted that any further delays from Bicycle will benefit competing products from Pfizer, potentially leading to a loss of market share and negatively impacting future revenue expectations.
  • Stock Price Reaction: Following the downgrade, Bicycle's American Depositary Receipt (ADR) price fell by $0.69, or 7.88%, closing at $8.07, reflecting market concerns regarding the company's outlook.
Wall Street analysts forecast BCYC stock price to rise
2 Analyst Rating
Wall Street analysts forecast BCYC stock price to rise
1 Buy
1 Hold
0 Sell
Moderate Buy
Current: 0.000
sliders
Low
24.00
Averages
24.00
High
24.00
Current: 0.000
sliders
Low
24.00
Averages
24.00
High
24.00
Truist
Hold
initiated
$10
AI Analysis
2025-11-24
Reason
Truist
Price Target
$10
AI Analysis
2025-11-24
initiated
Hold
Reason
Truist initiated coverage of Bicycle Therapeutics with a Hold rating and $10 price target. The time to market and ultimate market potential remains uncertain for Zele, pending further visibility from the Phase 2/3 Duravelo-2 trial, particularly as Padcev continues to entrench as a widely adopted standard of care, the analyst tells investors in a research note. Truist adds that it sees broader value from Bicycle's pipeline, including BT5528, and the radiopharma franchise, though these programs remain early in development and are unlikely to yield meaningful near-term contribution.
RBC Capital
Leonid Timashev
Outperform -> Sector Perform
downgrade
$27 -> $11
2025-10-31
Reason
RBC Capital
Leonid Timashev
Price Target
$27 -> $11
2025-10-31
downgrade
Outperform -> Sector Perform
Reason
RBC Capital analyst Leonid Timashev last night downgraded Bicycle Therapeutics to Sector Perform from Outperform with a price target of $11, down from $27, following the Q3 report. The company's pipeline programs are taking more time to reach inflection points, the analyst tells investors in a research note. RBC thinks Bicycle's near-term updates may not provide substantial enough data to de-risk its programs and drive share upside. As such, the firm moves to the sidelines pending greater visibility into the path forward for zelenectide and BT5528.
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Valuation Metrics

The current forward P/E ratio for Bicycle Therapeutics PLC (BCYC.O) is -1.94, compared to its 5-year average forward P/E of -6.59. For a more detailed relative valuation and DCF analysis to assess Bicycle Therapeutics PLC's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-6.59
Current PE
-1.94
Overvalued PE
-2.22
Undervalued PE
-10.97

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-4.06
Current EV/EBITDA
0.87
Overvalued EV/EBITDA
0.66
Undervalued EV/EBITDA
-8.77

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
41.99
Current PS
16.73
Overvalued PS
67.91
Undervalued PS
16.06

Financials

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Whales Holding BCYC

A
Artal Group S.A.
Holding
BCYC
+16.11%
3M Return
B
Baker Bros. Advisors LP
Holding
BCYC
-3.44%
3M Return

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Frequently Asked Questions

What is Bicycle Therapeutics PLC (BCYC) stock price today?

The current price of BCYC is 5.07 USD — it has increased 0.4

What is Bicycle Therapeutics PLC (BCYC)'s business?

Bicycle Therapeutics plc is a United Kingdom-based clinical-stage biopharmaceutical company developing a class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. The Company is evaluating zelenectide pevedotin, a Bicycle Toxin Conjugate (BTC) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target, and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist (Bicycle TICA) targeting Nectin-4 and agonizing CD137, in Company-sponsored clinical trials. Additionally, the Company is developing Bicycle Radio Conjugates (BRC) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology to develop therapies for diseases beyond oncology.

What is the price predicton of BCYC Stock?

Wall Street analysts forecast BCYC stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for BCYC is24.00 USD with a low forecast of 24.00 USD and a high forecast of 24.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Bicycle Therapeutics PLC (BCYC)'s revenue for the last quarter?

Bicycle Therapeutics PLC revenue for the last quarter amounts to 47.95M USD, increased 1193.28

What is Bicycle Therapeutics PLC (BCYC)'s earnings per share (EPS) for the last quarter?

Bicycle Therapeutics PLC. EPS for the last quarter amounts to USD, decreased -100.00

How many employees does Bicycle Therapeutics PLC (BCYC). have?

Bicycle Therapeutics PLC (BCYC) has 305 emplpoyees as of March 17 2026.

What is Bicycle Therapeutics PLC (BCYC) market cap?

Today BCYC has the market capitalization of 351.70M USD.