Zentalis Pharmaceuticals Announces 2026 Milestones for Azenosertib Development
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 06 2026
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Zentalis Pharmaceuticals provided a corporate update and highlighted key milestones and expected momentum in the azenosertib development program for 2026. 2025 Accomplishments: Completed enrollment in DENALI Part 2a, supporting registration-intended development of azenosertib; Aligned with the FDA on confirmatory ASPENOVA Phase 3 trial design; Strong data across three trials in PROC established a solid foundation for the lead indication in Cyclin E1-positive platinum-resistant ovarian cancer; Maintained a strong cash position supporting an estimated runway into late 2027 following strategic restructuring to focus pipeline and resources. Anticipated 2026 Milestones: DENALI Part 2a dose confirmation expected in first half of 2026; Confirmatory ASPENOVA Phase 3 trial initiation expected in first half of 2026; DENALI Part 2 topline readout on track and expected by year end 2026
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Analyst Views on ZNTL
Wall Street analysts forecast ZNTL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ZNTL is 6.60 USD with a low forecast of 4.00 USD and a high forecast of 10.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
6 Analyst Rating
4 Buy
2 Hold
0 Sell
Moderate Buy
Current: 2.560
Low
4.00
Averages
6.60
High
10.00
Current: 2.560
Low
4.00
Averages
6.60
High
10.00
About ZNTL
Zentalis Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers. The Company is engaged in developing azenosertib (ZN-c3), a potentially first-in-class WEE1 inhibitor, for patients with ovarian cancer and other tumor types. The inhibition of WEE1, a DNA damage response kinase, drives cancer cells into mitosis without being able to repair damaged DNA, resulting in cell death and thereby preventing tumor growth and potentially causing tumor regression. WEE1 acts as a regulator of the G1-S and G2-M cell cycle checkpoints, through negative regulation of both CDK1 and CDK2, to prevent replication of cells with damaged DNA. In clinical trials, azenosertib has been well tolerated and has demonstrated anti-tumor activity as a single agent across multiple tumor types.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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Oncolytics Biotech Advances Pelareorep for Anal Cancer with 29% Response Rate
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