Whitehawk Therapeutics to Present at Oppenheimer 36th Annual Healthcare Conference
- Presentation Schedule: Dr. Dave Lennon, CEO of Whitehawk Therapeutics, will present at the Oppenheimer 36th Annual Healthcare Life Sciences Conference on February 25, 2026, at 8:40 AM EST, showcasing the company's latest advancements in oncology treatments.
- Webcast Availability: The presentation will be live-streamed on Whitehawk Therapeutics' investor relations website and will be available for replay for approximately 30 days post-event, ensuring that investors and the public can access key information in a timely manner.
- Company Background: Whitehawk Therapeutics is a clinical-stage oncology therapeutics company focused on leveraging advanced technologies to enhance antibody-drug conjugate (ADC) cancer treatments, aiming to provide effective solutions for patients with difficult-to-treat cancers.
- Portfolio Advantages: The company boasts an advanced three-asset ADC portfolio, licensed exclusively from WuXi Biologics under a global commercialization agreement, designed to overcome the limitations of first-generation products and deliver significant therapeutic impact for patients.
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- Preclinical Research Findings: Whitehawk Therapeutics will present three preclinical research findings on antibody-drug conjugates (ADCs) at the 2026 American Association for Cancer Research Annual Meeting, providing comprehensive proof-of-concept for HWK-007, HWK-016, and HWK-206 aimed at improving cancer patient outcomes.
- High Efficacy Performance: The research indicates that Whitehawk's ADCs exhibit high potency with significant tumor regressions at low single-digit mg/kg doses, and in non-human primate studies, a highest non-severely toxic dose (HNSTD) of 60 mg/kg demonstrates excellent tolerability.
- Innovative Technology Application: The study utilizes Whitehawk's proprietary
- Preclinical Data Presentation: Whitehawk Therapeutics will present three preclinical abstracts at the 2026 American Association for Cancer Research Annual Meeting, showcasing comprehensive proof-of-concept for its ADC programs HWK-007, HWK-016, and HWK-206, aimed at improving cancer treatment outcomes.
- High Efficacy and Tolerability: These ADCs demonstrated high potency with tumor regressions in xenograft studies at low single-digit mg/kg doses, and in non-human primate studies, the highest non-severely toxic dose (HNSTD) reached 60 mg/kg, indicating excellent tolerability.
- Innovative Technology Utilization: Whitehawk's ADCs utilize its proprietary

- Trial Initiation: Whitehawk Therapeutics has received FDA clearance for its Phase 1 trial of HWK-007, which is now actively recruiting participants to evaluate its efficacy in lung and ovarian cancers, potentially offering new treatment options for patients.
- IND Submission: The company submitted an IND for HWK-016 to the FDA in December 2025, with plans to initiate Phase 1 trials this quarter targeting high MUC16-expressing ovarian and endometrial cancers, thereby expanding its therapeutic pipeline.
- Technological Edge: Both HWK-007 and HWK-016 leverage Whitehawk's advanced ADC technology platform, which combines a highly stable yet cleavable linker to enhance tumor targeting while minimizing off-target toxicity, aiming to improve treatment outcomes.
- Market Opportunity: PTK7 is the third most highly expressed tumor marker among clinically validated ADC targets, present in approximately 70% of tumors, positioning Whitehawk's new drugs to fill a significant market gap and address unmet medical needs.

- Trial Launch: Whitehawk Therapeutics has announced the active recruitment for its Phase 1 trial of HWK-007, aimed at evaluating its efficacy in PTK7-expressing tumors such as lung and ovarian cancers, marking a significant advancement in the company's oncology drug development.
- IND Submission: The company submitted an IND for HWK-016 to the FDA in December 2025, with a Phase 1 trial expected to start this quarter focusing on high MUC16-expressing ovarian and endometrial cancers, further expanding its antibody-drug conjugate (ADC) pipeline.
- Platform Advantages: Whitehawk's ADC technology platform features a highly stable yet cleavable linker designed to maximize tumor targeting while minimizing off-target toxicity, which is expected to provide more effective treatment options for patients and enhance market competitiveness.
- Data Release Expectations: The company anticipates reporting initial clinical data for both HWK-007 and HWK-016 in early 2027, which will provide crucial validation for the efficacy of its ADC programs and potentially drive future market opportunities.

- Leadership Enhancement: Whitehawk Therapeutics appoints Dr. Margaret Dugan, who has over 30 years of global oncology drug development experience, as Chief Medical Officer, aiming to leverage her expertise to enhance the company's clinical development capabilities in antibody-drug conjugates (ADCs) and accelerate their clinical progress.
- Rich Clinical Development Experience: Dr. Dugan has overseen more than 12 Phase 1 clinical programs and successfully facilitated regulatory approvals for drugs like capmatinib and ceritinib, which will provide valuable regulatory strategy support for Whitehawk's ADC portfolio, enhancing its market competitiveness.
- Rapid Advancement of Clinical Programs: While serving as CMO at Dracen Pharmaceuticals, Dr. Dugan successfully advanced the company's first clinical program through Phase 1 and secured Fast Track designation, an experience that will aid Whitehawk in achieving swift clinical translation for its ADC projects.
- Innovative Treatment Prospects: Dr. Dugan emphasizes that Whitehawk's ADC portfolio features unique target selection and differentiated profiles, which are expected to offer significant therapeutic opportunities for patients with difficult-to-treat cancers, further solidifying the company's strategic position in oncology treatment.

Company Announcement: Whitehawk Therapeutics, Inc. will have its President and CEO, Dave Lennon, present at the Jefferies Global Healthcare Conference in London on November 18, 2025, at 11:30 AM GMT.
Webcast Availability: A live webcast of the presentation will be accessible on the Whitehawk Therapeutics investor relations website and will be available for replay for about 30 days post-event.
Company Overview: Whitehawk Therapeutics focuses on oncology therapeutics, utilizing advanced technologies to enhance antibody drug conjugate (ADC) cancer treatments, particularly for challenging cancers.
Partnership Details: The company’s ADC portfolio is developed under an exclusive agreement with WuXi Biologics, aimed at improving treatment outcomes for patients with difficult-to-treat cancers.






