What Caused Sensei Biotherapeutics (SNSE) Stock to Surge Nearly 63% in After-Hours Trading?

Written by Emily J. Thompson, Senior Investment Analyst

SNSE-4.17%

Source: Benzinga

Updated: Dec 05 2025

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Source: Benzinga

Sensei Biotherapeutics Stock Surge: Sensei Biotherapeutics Inc. (SNSE) saw a significant increase of 62.88% in after-hours trading, reaching $17.20, following a closing price of $10.56, which was up 21.38% for the day.
Cambrian BioPharma Share Sales: Cambrian BioPharma Inc., a 10% shareholder, filed two Form 144 documents indicating plans to sell 27,066 common shares valued at $235,744, with transactions to be executed through Fidelity Brokerage Services LLC.
Stock Performance Overview: The stock of Sensei Biotherapeutics has increased by 2.52% year-to-date and 46.26% over the past six months, with a market capitalization of $13.32 million and trading between $5 and $18.35 over the last year.
BBAI Stock Momentum: BigBear.ai (BBAI) is trending with a momentum ranking in the 48th percentile, indicating strong long-term gains and stable performance in both short and medium terms.

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About SNSE

Sensei Biotherapeutics, Inc. is a clinical-stage immuno-oncology company, which is focused on the discovery and development of therapeutics for cancer patients. Through its Tumor Microenvironment Activated biologics (TMAb) platform, the Company develops conditionally active therapeutics designed to disable immunosuppressive signals or activate immunostimulatory signals selectively in the tumor microenvironment to unleash T cells against tumors. Its lead investigational candidate is SNS-101, a conditionally active antibody designed to block the V-domain Ig suppressor of T cell activation checkpoint selectively within the low pH tumor microenvironment. It is also developing SNS-102, a conditionally active monoclonal antibody targeting V-Set and Immunoglobulin Domain Containing 4 (VSIG-4); SNS-103, a conditionally active monoclonal antibody targeting ecto-nucleoside triphosphate diphosphohydrolase-1 (ENTPDase1), CD39; and SNS-201, a conditionally active VISTAxCD28 bispecific antibody.

About the author

Emily J. Thompson

Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.