Verastem Oncology to Host Q4 2025 Financial Results Call
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 1 day ago
0mins
Should l Buy VSTM?
Source: Businesswire
- Conference Call Announcement: Verastem Oncology will host a conference call on March 4, 2026, at 4:30 PM ET to discuss its Q4 and full-year 2025 financial results, aiming to provide investors with insights into its latest business developments and financial performance.
- Access Instructions: Investors can dial (888) 596-4144 for U.S. access or (646) 968-2525 for international calls, entering passcode 7321921 at least 10 minutes prior to the start time to ensure smooth participation in this important financial update.
- Live Webcast and Replay: The call will be available via a live audio webcast on the company's investor website, accompanied by slides, and a replay will be archived post-event, allowing investors who cannot attend live to access the information.
- Company Overview: Verastem Oncology focuses on developing new medicines for RAS/MAPK pathway-driven cancers, with products like AVMAPKI™ and FAKZYNJA™ CO-PACK already in the market, showcasing the company's innovative capabilities in the biopharmaceutical sector.
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Analyst Views on VSTM
Wall Street analysts forecast VSTM stock price to rise
6 Analyst Rating
6 Buy
0 Hold
0 Sell
Strong Buy
Current: 5.710
Low
14.00
Averages
15.60
High
20.00
Current: 5.710
Low
14.00
Averages
15.60
High
20.00
About VSTM
Verastem, Inc. is a late-stage development biopharmaceutical company, which focuses on the development and commercialization of new medicines to improve the lives of patients diagnosed with ras sarcoma (RAS)/ mitogen-activated pathway kinase (MAPK) pathway-driven cancers. Its product candidates include avutometinib and defactinib. Avutometinib is an oral RAF/MEK clamp that inhibits MEK1/2 kinase activities and induces inactive complexes of MEK with A-Raf proto-oncogene, potentially serine/threonine kinase (ARAF), B-Raf proto-oncogene serine/threonine kinase (BRAF) and C-raf proto-oncogene serine/threonine kinase, creating antitumor response through maximal RAS/MAPK pathway inhibition. Defactinib is an oral, selective inhibitor of FAK and proline-rich tyrosine kinase (PYK2), the two members of the focal adhesion kinase family of non-receptor protein tyrosine kinases. FAK and PYK2 integrate signals from integrin and growth factor receptors to regulate cell proliferation.
About the author

Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
- Conference Call Announcement: Verastem Oncology will host a conference call on March 4, 2026, at 4:30 PM ET to discuss its Q4 and full-year 2025 financial results, aiming to provide investors with insights into its latest business developments and financial performance.
- Access Instructions: Investors can dial (888) 596-4144 for U.S. access or (646) 968-2525 for international calls, entering passcode 7321921 at least 10 minutes prior to the start time to ensure smooth participation in this important financial update.
- Live Webcast and Replay: The call will be available via a live audio webcast on the company's investor website, accompanied by slides, and a replay will be archived post-event, allowing investors who cannot attend live to access the information.
- Company Overview: Verastem Oncology focuses on developing new medicines for RAS/MAPK pathway-driven cancers, with products like AVMAPKI™ and FAKZYNJA™ CO-PACK already in the market, showcasing the company's innovative capabilities in the biopharmaceutical sector.
See More
- Conference Call Announcement: Verastem Oncology will host a conference call on March 4, 2026, at 4:30 PM ET to discuss its Q4 and full-year 2025 financial results, reflecting the company's commitment to transparency and investor communication.
- Access Details: Investors can dial (888) 596-4144 for U.S. access or (646) 968-2525 for international calls, entering passcode 7321921 at least 10 minutes prior to the event, ensuring smooth participation.
- Live Webcast and Replay: The call will be available via a live audio webcast on the company's website under the
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- Revenue Expectations: Verastem anticipates net product revenue of approximately $17.5 million for Q4 2025 and about $30.9 million for the full year, based on preliminary unaudited results, primarily driven by sales of AVMAPKI FAKZYNJA CO-PACK following its U.S. approval in May 2025.
- Cash Reserves: As of December 31, 2025, Verastem reported $205 million in cash, cash equivalents, and investments, and on a pro forma basis, including proceeds from outstanding cash warrants, total cash is approximately $234 million, which is expected to fund operations into the first half of 2027.
- Clinical Development: The company plans to continue advancing the clinical development of its oral KRAS G12D inhibitor, VS-7375, and expects to report an interim update from its Phase 1/2 trial in the first half of 2026, which will provide critical data for future product line development.
- Leadership Engagement: Verastem's leadership will participate in a fireside chat at the Guggenheim Emerging Outlook Conference on February 11, which will help enhance the company's visibility among investors and strengthen market engagement.
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- 2025 Revenue Outlook: Verastem anticipates net product revenues of approximately $30.9 million for AVMAPKI™ FAKZYNJA™ CO-PACK in 2025, with about $17.5 million expected in Q4, reflecting strong market demand following FDA approval in May 2025, marking a successful transition to a commercial-stage company.
- Strong Cash Position: As of December 31, 2025, Verastem reported cash, cash equivalents, and investments totaling $205 million, with pro forma cash reaching $234 million after warrant exercises, ensuring operational runway into the first half of 2027, indicating robust financial health.
- Accelerated Clinical Development: The company plans to rapidly advance its clinical development of VS-7375, a selective oral KRAS G12D inhibitor, which is expected to demonstrate best-in-class potential across multiple solid tumor indications, further solidifying its competitive edge in oncology.
- Future Strategic Focus: In 2026, Verastem will concentrate on maximizing the commercial launch of AVMAPKI FAKZYNJA CO-PACK while advancing its differentiated pipeline targeting RAS/MAPK pathway-driven cancers, aiming for sustainable long-term growth and self-sustaining commercialization by the second half of 2026.
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- Market Potential: The global oncology market is projected to reach $668 billion by 2034, positioning companies like Oncolytics Biotech at the forefront of this rapid growth, particularly in innovative treatments for gastrointestinal cancers, indicating strong market demand and investment appeal.
- Clinical Trial Progress: Oncolytics Biotech's pelareorep achieved a 33% response rate in colorectal cancer patients, significantly surpassing the 6-11% typical response rates of conventional chemotherapy, which not only enhances treatment efficacy but also has the potential to redefine treatment standards in this field, bolstering the company's competitive edge.
- Management Team Upgrade: The recent appointments of John McAdory as Executive Vice President of Strategy and Operations and Yujun Wu as Vice President, Head of Biostatistics, both with extensive clinical trial experience, will provide critical support for Oncolytics' execution of complex multi-country registration trials, ensuring rapid and compliant advancement.
- FDA Trial Design Approval: Oncolytics has secured FDA approval for its Phase 3 trial design for pancreatic cancer, marking the imminent launch of the only immunotherapy registration trial planned for this notoriously difficult-to-treat disease, further solidifying its leadership position in oncology innovation.
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- Market Potential: The global oncology market is projected to reach $668 billion by 2034, positioning Oncolytics Biotech at the forefront of this rapid growth, particularly in the treatment of gastrointestinal cancers through innovative immunotherapy.
- Clinical Trial Progress: Oncolytics Biotech's pelareorep achieved a 33% response rate in colorectal cancer patients, significantly surpassing the 6-11% response rates typical of standard chemotherapy, indicating a potential shift in treatment paradigms.
- Management Team Upgrade: The company appointed two key executives, John McAdory and Yujun Wu, with extensive experience in complex late-stage clinical trials and biostatistics, respectively, which will provide robust support for Oncolytics' clinical trial execution.
- FDA Trial Design Approval: Oncolytics has secured FDA approval for its Phase 3 trial design for pancreatic cancer, making it the only immunotherapy registration trial currently planned for this notoriously difficult-to-treat disease, marking a significant advancement for the company.
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