Traws Pharma's Oral COVID Treatment Demonstrates Results Similar to Paxlovid
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 17 2025
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Source: Benzinga
Interim Data Release: Traws Pharma Inc. announced interim results from a Phase 2 trial of ratutrelvir, an oral protease inhibitor for mild-to-moderate COVID-19, showing a differentiated clinical profile compared to Pfizer's Paxlovid.
Efficacy and Safety: The analysis indicated that patients treated with ratutrelvir experienced symptom alleviation comparable to those on Paxlovid, with no observed viral rebound events in the ratutrelvir group and fewer adverse events reported.
Patient Cohorts: Among the 37 patients analyzed, 25 received ratutrelvir, while 12 were treated with Paxlovid; notably, 16.2% of ratutrelvir patients were ineligible for Paxlovid due to contraindications.
Strategic Implications: Traws Pharma's Chief Medical Officer highlighted the potential of ratutrelvir in reducing long COVID symptoms, supported by early symptom improvement and favorable tolerability observed in the trial.
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Analyst Views on TRAW
Wall Street analysts forecast TRAW stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for TRAW is 8.00 USD with a low forecast of 8.00 USD and a high forecast of 8.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
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Current: 2.460
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About TRAW
Traws Pharma, Inc. is a clinical stage biopharmaceutical company dedicated to developing novel therapies to target critical threats to human health in respiratory viral diseases. It integrates antiviral drug development, medical intelligence and regulatory strategy in the treatment of viral diseases. The Cadvancing novel investigational oral small-molecule antiviral agents that have potent activity against difficult to treat or resistant virus strains that threaten human health: bird flu and seasonal influenza, and COVID-19/Long COVID. Its four clinical programs consist of Tivoxavir marboxil, Ratutrelvir (TRX0), Narazaciclib, and Rigosertib. Tivoxavir marboxil is a small-molecule cap-dependent endonuclease inhibitor. Ratutrelvir (TRX01) is an inhibitor of the main protease (also known as 3CL protease) of the SARS-CoV-2 virus. arazaciclib is its oral CDK4-plus inhibitor intended initially to treat breast cancers, endometrial and other cancers. Rigosertib is its second asset in oncology.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Traws Pharma Advances Ratutrelvir COVID-19 Trial
- Trial Progress: Traws Pharma has completed enrollment of 90 patients in its Ratutrelvir clinical trial, comparing the drug with Pfizer's Paxlovid, aiming to provide an alternative treatment for patients unable to use Paxlovid.
- Efficacy and Tolerability: Early data analysis indicates that Ratutrelvir has a favorable tolerability profile, faster symptom resolution, and no observed viral rebound events, supporting its potential utility in reducing post-acute sequelae of SARS-CoV-2 infection (Long COVID).
- Influenza Treatment Update: Traws is also advancing Tivoxavir Marboxil as a potential once-monthly oral preventive treatment for seasonal flu, further expanding its pipeline targeting respiratory viral diseases.
- Market Reaction: Although TRAW shares slipped after the opening bell, they gained about 5% in premarket trading, reflecting investor optimism regarding the company's research progress, with the stock rebounding over 115% in 2026.
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Traws Pharma Reports Clinical Progress on Ratutrelvir and Tivoxavir Marboxil
- Clinical Trial Results: Traws Pharma's ratutrelvir shows fewer adverse events and no viral rebounds in a 90-patient Phase 2 study compared to PAXLOVID®, indicating its potential advantages in treating COVID-19, especially for patients ineligible for PAXLOVID®.
- Efficacy Improvement: The 600mg daily dose of ratutrelvir over 10 days significantly shortens symptom resolution time and has not shown viral rebound events, potentially offering a more effective treatment option for acute COVID-19 patients and supporting its impact on long-term outcomes.
- New Influenza Prevention Approach: Traws Pharma's tivoxavir marboxil is predicted to provide 28-day protection against influenza, with the new compressed tablet formulation showing over 3X effective blood levels in prior studies, potentially offering an innovative prophylactic treatment for seasonal influenza.
- Future Research Plans: The company plans to conduct an influenza prophylaxis challenge study in June 2026, and if results are positive, will advance tivoxavir marboxil into registration studies, further expanding its application potential in the antiviral market.
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