Taysha Reports Q4 Revenue of $9.77M, Exceeding Expectations

Reports Q4 revenue $9.77M, consensus $6.3M. As of December 31, 2025, Taysha had $319.8M in cash and cash equivalents. Expects current cash resources will be sufficient to fund planned operating expenses into 2028. "2025 was a year of significant execution for Taysha, setting the stage for what we expect to be a transformative year ahead. We are focused on completing the pivotal development of TSHA-102 and bolstering our commercial readiness efforts as we advance toward potential registration. Multiple patients have been dosed in our REVEAL pivotal trial, and we remain on track to complete dosing in the REVEAL pivotal and ASPIRE trials in the second quarter of this year," said CEO Sean Nolan. "Importantly, we have maintained ongoing, constructive dialogue with the FDA over the past two years that continues to support a streamlined path to registration. We recently received written FDA alignment on our proposed PPQ and comparability strategy, including the ability to leverage data across the REVEAL and ASPIRE trials to support our planned BLA submission. In parallel, recent market research reinforces the strong commercial opportunity for TSHA-102, demonstrating high anticipated demand from both clinicians and caregivers in the U.S. The research also indicates a clear preference for intrathecal administration, which is viewed as familiar, accessible and scalable, enabling the potential to safely and efficiently treat patients across multiple institutions. With a favorable tolerability profile demonstrated to date, continued patient enrollment and a well defined regulatory and commercial path, we believe TSHA 102 has the potential to meaningfully address the genetic root cause of this devastating disease with high unmet need."