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TSHA Overview

-
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
6.695
Open
6.470
VWAP
6.53
Vol
1.09M
Mkt Cap
1.85B
Low
6.290
Amount
7.09M
EV/EBITDA(TTM)
--
Total Shares
287.27M
EV
1.58B
EV/OCF(TTM)
--
P/S(TTM)
210.20
Taysha Gene Therapies Inc is a clinical-stage biotechnology company, which is focused on advancing adeno-associated virus (AAV)-based gene therapies for severe monogenic diseases of the central nervous system. The Company’s lead clinical program, TSHA-102, is in development for the treatment of Rett syndrome, a rare neurodevelopmental disorder. The Company is evaluating TSHA-102 in the REVEALPhase I/II adolescent and adult clinical trial, which is a first-in-human, open-label, randomized, dose escalation and dose-expansion, multicenter study evaluating the safety and preliminary efficacy of TSHA-102 in female patients aged 12-years and older with Rett syndrome. It has acquired a worldwide right to a clinical-stage, intrathecally dosed AAV9 gene therapy program, TSHA-120, for the treatment of giant axonal neuropathy (GAN). TSHA-105 is a gene replacement therapy in development for the treatment of SLC13A5 deficiency, a rare autosomal recessive epileptic encephalopathy.
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Events Timeline

(ET)
2026-03-19
08:10:00
Taysha Reports Q4 Revenue of $9.77M, Exceeding Expectations
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2026-03-06 (ET)
2026-03-06
08:10:00
Taysha Gene Therapies Grants New Employee RSUs and Options
select
2026-02-06 (ET)
2026-02-06
08:10:00
Taysha Gene Therapies Grants 349,000 Restricted Stock Units to New Employees
select
2026-01-06 (ET)
2026-01-06
08:20:00
Taysha Gene Therapies TSHA-102 Program Progress Announced
select

News

seekingalpha
9.5
03-19seekingalpha
Taysha Gene Therapies Reports Significant Progress in 2025 Earnings Call
  • Clinical Trial Progress: Taysha's REVEAL Phase I/II trial made significant strides in 2025, with CEO Sean Nolan noting that multiple patients have been dosed across various sites, and the company expects to complete dosing by Q2 2026, demonstrating strong execution in addressing Rett syndrome.
  • Financial Position Improvement: R&D expenses rose to $86.4 million in 2025, up from $66 million in 2024, reflecting ongoing investments in research and clinical activities, while cash and cash equivalents stood at $319.8 million at year-end, sufficient to fund operations into 2028.
  • Market Access Strategy: The appointment of Brad Martin as Senior Vice President of Market Access and Value aims to further strengthen the commercial leadership team to support the potential commercialization of TSHA-102, indicating the company's focus on market opportunities.
  • Successful FDA Engagement: Taysha received FDA breakthrough therapy designation and achieved written alignment on REVEAL and ASPIRE trial designs, showcasing positive regulatory progress that lays the groundwork for future BLA submissions.
seekingalpha
9.5
03-19seekingalpha
Taysha Gene Therapies Reports Better-Than-Expected Earnings
  • Earnings Highlights: Taysha Gene Therapies reported a FY GAAP EPS of -$0.34, beating expectations by $0.02, indicating improvements in cost control and operational efficiency, although the company remains in a loss position.
  • Revenue Growth: The company reported revenue of $9.77M, a 17.3% year-over-year increase, exceeding market expectations by $3.47M, suggesting sustained demand for its products and potentially laying the groundwork for future profitability.
  • Market Reaction: Following the earnings release, investor confidence in the company's prospects has strengthened, likely driving stock price increases, reflecting market recognition of its gene therapy products and optimistic expectations for potential market opportunities.
  • Strategic Implications: The positive performance in this earnings report may provide Taysha Gene Therapies with the necessary funding to further invest in and develop its gene therapies, helping it secure a more advantageous position in a competitive market.
seekingalpha
9.5
03-18seekingalpha
Taysha Gene Therapies to Announce FY Earnings Results
  • Earnings Announcement Date: Taysha Gene Therapies is set to release its FY earnings report on March 19 before market open, with investors keenly awaiting performance insights to gauge future growth potential.
  • EPS Expectations: The consensus EPS estimate stands at -$0.34, reflecting a 5.6% year-over-year improvement, indicating the company's efforts to enhance profitability, albeit still in a loss position.
  • Revenue Decline Forecast: Revenue is projected at $6.3 million, representing a 24.4% year-over-year decline, highlighting challenges in market competition and product promotion that may affect investor confidence.
  • Performance Beat Record: Over the past year, Taysha has beaten EPS estimates 50% of the time and revenue estimates 75% of the time, demonstrating a degree of financial management capability despite current challenges.
CNBC
9.0
03-06CNBC
FDA Rejects Multiple Experimental Drug Applications, Raising Investor Concerns
  • FDA Drug Rejections: The U.S. FDA has denied or discouraged applications for at least eight drugs over the past year, including UniQure's gene therapy for Huntington's disease, indicating regulatory uncertainty that could impact future treatment approvals.
  • Investor Concerns Rise: Investors are increasingly wary as the FDA appears to change its standards for drug applications, particularly for treatments targeting hard-to-treat diseases, leading to diminished confidence in ongoing development efforts.
  • Changing Regulatory Standards: The FDA's request for UniQure to conduct new placebo-controlled trials contradicts previous guidance, highlighting inconsistencies in the agency's approval process that may create uncertainty for companies in their R&D efforts.
  • Uncertain Future Outlook: Analysts warn that if the FDA does not approve Denali Therapeutics' drug for Hunter syndrome, it could further undermine other companies' confidence in running open-label studies, potentially stifling innovation across the industry.
Newsfilter
7.0
03-06Newsfilter
FDA Drug Approval Uncertainty Intensifies
  • Drug Applications Denied: According to RTW Investments, the FDA has denied or discouraged applications for at least eight new drugs over the past year, including gene therapies for Huntington's and Hunter syndrome, raising investor concerns about the prospects for other drugs in the pipeline.
  • Changing Regulatory Standards: The FDA's request for UniQure to conduct new placebo-controlled studies contradicts previous guidance, leading investors to doubt the agency's consistency and fearing that this could jeopardize future treatment approvals.
  • Negative Market Reaction: Stocks of several biotech companies have declined following FDA rejections, with analysts noting a stark conflict between the FDA's recent decisions and the flexibility promised by its leadership, causing investors to lose confidence in companies relying on FDA leniency.
  • Uncertain Future Outlook: Although FDA officials assert that biomarkers can lead to accelerated approvals, investors remain confused about the agency's approval standards, particularly for drugs targeting rare diseases, making future approval pathways increasingly uncertain.
Globenewswire
2.0
01-06Globenewswire
Taysha Gene Therapies Doses First Patient in TSHA-102 Pivotal Trial for Rett Syndrome
  • Trial Progress: Taysha Gene Therapies successfully dosed the first patient in the TSHA-102 pivotal trial in Q4 2025, with plans to complete dosing for all 15 patients by Q2 2026, marking a significant milestone in the treatment of Rett syndrome.
  • FDA Alignment: The company reached written alignment with the FDA to include three months of safety data from the ASPIRE trial in its planned BLA submission, aiming to enable broad labeling for patients aged two and older, which will expedite the path to market.
  • Market Opportunity: With an estimated 15,000 to 20,000 patients affected by Rett syndrome across the U.S., EU, and U.K., Taysha aims to redefine the treatment paradigm for this high unmet need disease through compelling clinical data from TSHA-102, presenting a significant market opportunity.
  • Long-term Data Update: An update on long-term safety and efficacy data from the REVEAL trial is expected in H1 2026, which will provide crucial support for the company's future treatment strategies and enhance its competitive position in the market.
Wall Street analysts forecast TSHA stock price to rise
11 Analyst Rating
Wall Street analysts forecast TSHA stock price to rise
11 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
8.00
Averages
11.60
High
19.00
Current: 0.000
sliders
Low
8.00
Averages
11.60
High
19.00
Canaccord
Whitney Ijem
Buy
maintain
$14 -> $17
AI Analysis
2026-04-06
Reason
Canaccord
Whitney Ijem
Price Target
$14 -> $17
AI Analysis
2026-04-06
maintain
Buy
Reason
Canaccord analyst Whitney Ijem raised the firm's price target on Taysha Gene Therapies to $17 from $14 and keeps a Buy rating on the shares. The firm said the company reiterated dosing completion in both REVEAL and ASPIRE trials are expected in 2Q26. The FDA recently cleared initiation of ASPIRE, where n=3 pts, aged 2 to less than4yo will receive a 1E15 dose, but scaled down to account for the lower brain volume in the younger population. Up next, the firm is looking forward to the updated Part A data expected in 2Q26 where all N=12 pts will have a minimum of 12month follow-up, continued evidence of milestone gains and a clean safety profile will bode well for the pivotal.
Wells Fargo
Zachary Fadem
Overweight
maintain
$8 -> $11
2026-01-05
Reason
Wells Fargo
Zachary Fadem
Price Target
$8 -> $11
2026-01-05
maintain
Overweight
Reason
Wells Fargo analyst Zachary Fadem raised the firm's price target on Taysha Gene Therapies to $11 from $8 and keeps an Overweight rating on the shares. The firm sees another year of outperformance for the stock, driven by continued momentum in the company's pivotal Rett syndrome study following last year's alignment with FDA on a favorable design.
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Valuation Metrics

The current forward P/E ratio for Taysha Gene Therapies Inc (TSHA.O) is 0.00, compared to its 5-year average forward P/E of -4.34. For a more detailed relative valuation and DCF analysis to assess Taysha Gene Therapies Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-4.34
Current PE
0.00
Overvalued PE
-1.41
Undervalued PE
-7.28

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-2.85
Current EV/EBITDA
-1.91
Overvalued EV/EBITDA
-0.54
Undervalued EV/EBITDA
-5.15

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
44.98
Current PS
11.93
Overvalued PS
104.31
Undervalued PS
-14.36

Financials

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Whales Holding TSHA

A
Artal Group S.A.
Holding
TSHA
+19.34%
3M Return
A
Avoro Capital Advisors LLC
Holding
TSHA
+14.87%
3M Return
V
Vestal Point Capital, LP
Holding
TSHA
+12.47%
3M Return
A
Affinity Asset Advisors, LLC
Holding
TSHA
+10.72%
3M Return
R
RA Capital Management, L.P.
Holding
TSHA
+7.21%
3M Return
B
Baker Bros. Advisors LP
Holding
TSHA
+6.01%
3M Return

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Frequently Asked Questions

What is Taysha Gene Therapies Inc (TSHA) stock price today?

The current price of TSHA is 6.595 USD — it has increased 2.57

What is Taysha Gene Therapies Inc (TSHA)'s business?

Taysha Gene Therapies Inc is a clinical-stage biotechnology company, which is focused on advancing adeno-associated virus (AAV)-based gene therapies for severe monogenic diseases of the central nervous system. The Company’s lead clinical program, TSHA-102, is in development for the treatment of Rett syndrome, a rare neurodevelopmental disorder. The Company is evaluating TSHA-102 in the REVEALPhase I/II adolescent and adult clinical trial, which is a first-in-human, open-label, randomized, dose escalation and dose-expansion, multicenter study evaluating the safety and preliminary efficacy of TSHA-102 in female patients aged 12-years and older with Rett syndrome. It has acquired a worldwide right to a clinical-stage, intrathecally dosed AAV9 gene therapy program, TSHA-120, for the treatment of giant axonal neuropathy (GAN). TSHA-105 is a gene replacement therapy in development for the treatment of SLC13A5 deficiency, a rare autosomal recessive epileptic encephalopathy.

What is the price predicton of TSHA Stock?

Wall Street analysts forecast TSHA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for TSHA is11.60 USD with a low forecast of 8.00 USD and a high forecast of 19.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Taysha Gene Therapies Inc (TSHA)'s revenue for the last quarter?

Taysha Gene Therapies Inc revenue for the last quarter amounts to 5.49M USD, increased 171.27

What is Taysha Gene Therapies Inc (TSHA)'s earnings per share (EPS) for the last quarter?

Taysha Gene Therapies Inc. EPS for the last quarter amounts to -0.08 USD, increased 14.29

How many employees does Taysha Gene Therapies Inc (TSHA). have?

Taysha Gene Therapies Inc (TSHA) has 99 emplpoyees as of April 20 2026.

What is Taysha Gene Therapies Inc (TSHA) market cap?

Today TSHA has the market capitalization of 1.85B USD.