Seer Secures Patent Review Support for Nanoparticle Technology
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 1 day ago
0mins
Should l Buy SEER?
Seer (SEER) announced that the Patent Trial and Appeal Board, or PTAB, of the U.S. Patent and Trademark Office issued a Final Written Decision on March 23 in an inter partes review of U.S. Patent No. 11,435,360 B2. The inter partes review was filed by PreOmics and Biognosys, each a subsidiary of Bruker (BRKR), challenging 11 of 29 claims of the '360 Patent. The '360 patent covers methods for analyzing biological samples using engineered nano- and microparticles that form protein coronas, resulting in protein enrichment that underlies Seer's Proteograph platform for deep proteomic analysis. The '360 Patent is owned by The Brigham and Women's Hospital, Inc. and is exclusively licensed to Seer. A total of 23 claims, including five challenged claims and 18 unchallenged claims, remain valid and protect Seer's nanoparticle protein enrichment technology for analyzing biological samples, including cells, tissues and biofluids. The upheld claims are directed to detecting proteins across a wide concentration range and to particle-related aspects of Seer's technology, both of which enable deep proteomic analysis.
Trade with 70% Backtested Accuracy
Stop guessing "Should I Buy SEER?" and start using high-conviction signals backed by rigorous historical data.
Sign up today to access powerful investing tools and make smarter, data-driven decisions.
Analyst Views on SEER
About SEER
Seer, Inc. is a life sciences company. It is developing products that open a new gateway to the proteome. Its Proteograph product suite is an integrated solution that includes proprietary engineered nanoparticles, consumables, automation instrumentation and software to perform proteomic analysis at scale in a matter of hours. The Proteograph has detected over 36,000 proteins across multiple species, and its performance and capabilities have been demonstrated in over 33 peer-reviewed publications, preprints and reviews. The Proteograph Product Suite is detector-agnostic and is adaptable to other protein detection instruments. The MS component of the Proteograph workflow is either provided by the researcher’s laboratory, can be outsourced to a third-party provider, or be run through the Seer Technology Access Center (STAC), which is its in-house service program. It has launched Proteograph XT, which enhances the sample throughput of the Proteograph Product Suite and MS instrument.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
SEER INC: PATENT BOARD AFFIRMS SEER'S NANO AND MICRO PARTICLE PROTEIN ENRICHMENT PATENT AGAINST BRUKER SUBSIDIARIES' CHALLENGE
Patent Board Decision: The Patent Board has upheld Seer's patent related to nano and microparticle protein enrichment.
Challenge by Bruker: This decision comes in response to a challenge posed by Bruker Subsidiaries regarding the validity of Seer's patent.
See More
RADOFF-JEC GROUP URGES SEER BOARD TO INITIATE SALE PROCESS
- Announcement of Sale Process: The Radoff-Jec Group has called on the Seer Board to announce a sale process for the company.
- Strategic Move: This move is seen as a strategic step to enhance shareholder value and attract potential buyers.
See More
Seer, Inc. Reports Q4 2025 Earnings with Caution on Future Guidance
- Revenue Growth: Seer reported Q4 2025 revenue of $4.2 million, bringing full-year revenue to $16.6 million, reflecting a 17% year-over-year increase; however, uncertainties around NIH funding impacted customer spending decisions, leading to underperformance this quarter.
- Product Innovation: CEO Farokhzad highlighted advancements in the Proteograph ONE assay and SP200 automation instrument, enabling over 1,000 samples per week, nearly a tenfold increase from 112 samples per week in 2021, showcasing significant technological progress.
- Share Repurchase Program: The company announced a new $25 million share repurchase authorization, having repurchased 5.3 million shares in 2025, reducing total outstanding shares by 13%, aimed at enhancing shareholder value and boosting market confidence.
- Cautious Future Outlook: CFO Horn projected 2026 revenue between $16 million and $18 million, reflecting cautious customer spending in an uncertain funding environment, with management emphasizing the need for clear market momentum before increasing revenue projections.
See More
Seer Releases 2026 Financial Guidance
- Earnings Report: Seer's Q4 GAAP EPS of -$0.29 beats expectations by $0.03, indicating an improvement in profitability, although the company remains in a loss position.
- Revenue Growth: The Q4 revenue of $4.2M reflects a 5.0% year-over-year increase, yet it falls short of expectations by $0.4M, highlighting challenges in market demand that could impact future investor confidence.
- 2026 Financial Guidance: Seer anticipates full-year 2026 revenue to range between $16 million and $18 million, representing approximately 3% growth at the midpoint compared to 2025, indicating a cautiously optimistic outlook despite slowing growth.
- Market Reaction: While the Q4 EPS exceeded expectations, the revenue miss may lead investors to adopt a cautious stance regarding Seer's future performance, potentially affecting its stock price trajectory.
See More
Seer Inc. Faces Severe Undervaluation Amid Disastrous Operating Results
- Stock Price Collapse: Since its IPO in December 2020, Seer's stock price has plummeted over 96%, indicating a severe loss of shareholder trust under the leadership of Co-Founder and CEO Omid Farokhzad, resulting in significant market value erosion.
- Severe Cash Burn: With a projected revenue midpoint of $17.5 million for 2025, Seer's revenue has only increased by $2 million since 2022, while operational cash burn reached $138.8 million and capital expenditures totaled $11.4 million, leading to a staggering cash use of $150.2 million, meaning over $75 million in cash investment is required for every $1 million of revenue growth.
- Governance Failures: Seer's market capitalization stands at $110.5 million, significantly below its cash reserves of $251.2 million, reflecting a profound mistrust in the Board and management, which has led to ongoing shareholder value destruction.
- Inappropriate Executive Compensation: From 2021 to 2024, Omid Farokhzad's total reported compensation reached $24.9 million, averaging approximately $6 million annually, which is nearly one-third of the company's yearly revenue, as the Board has failed to hold him accountable for poor operational results while continuing to enrich him at the expense of shareholders.
See More
Seer Publishes Large GWAS Study Validating Mass Spectrometry's Role in Proteomics
- Significant Findings: Seer's Proteograph platform detected 5,753 proteins and quantified 1,980 in a GWAS involving approximately 1,600 blood samples, showcasing its robust capabilities in protein research and advancing precision medicine.
- Importance of Validation: The study reveals that about one-third of protein-gene associations reported without mass spectrometry validation do not replicate, underscoring the critical role of mass spectrometry in ensuring the reliability of drug targets and clinical biomarkers, thereby reducing technical noise in research.
- New Discoveries: Among 364 genetic variants associated with protein abundance, 102 were validated in an independent cohort, with 35 being newly reported, thus expanding the knowledge base of genetic regulation of proteins and deepening biomedical research.
- Clinical Impact: By providing more reliable protein measurements, Seer's research lays the groundwork for drug discovery and biomarker development, ensuring that future therapies are built on real biology, which increases the likelihood of success in clinical applications.
See More
SEER INC: PATENT BOARD AFFIRMS SEER'S NANO AND MICRO PARTICLE PROTEIN ENRICHMENT PATENT AGAINST BRUKER SUBSIDIARIES' CHALLENGE
Patent Board Decision: The Patent Board has upheld Seer's patent related to nano and microparticle protein enrichment.
Challenge by Bruker: This decision comes in response to a challenge posed by Bruker Subsidiaries regarding the validity of Seer's patent.
See More
RADOFF-JEC GROUP URGES SEER BOARD TO INITIATE SALE PROCESS
- Announcement of Sale Process: The Radoff-Jec Group has called on the Seer Board to announce a sale process for the company.
- Strategic Move: This move is seen as a strategic step to enhance shareholder value and attract potential buyers.
See More
Seer, Inc. Reports Q4 2025 Earnings with Caution on Future Guidance
- Revenue Growth: Seer reported Q4 2025 revenue of $4.2 million, bringing full-year revenue to $16.6 million, reflecting a 17% year-over-year increase; however, uncertainties around NIH funding impacted customer spending decisions, leading to underperformance this quarter.
- Product Innovation: CEO Farokhzad highlighted advancements in the Proteograph ONE assay and SP200 automation instrument, enabling over 1,000 samples per week, nearly a tenfold increase from 112 samples per week in 2021, showcasing significant technological progress.
- Share Repurchase Program: The company announced a new $25 million share repurchase authorization, having repurchased 5.3 million shares in 2025, reducing total outstanding shares by 13%, aimed at enhancing shareholder value and boosting market confidence.
- Cautious Future Outlook: CFO Horn projected 2026 revenue between $16 million and $18 million, reflecting cautious customer spending in an uncertain funding environment, with management emphasizing the need for clear market momentum before increasing revenue projections.
See More
Seer Releases 2026 Financial Guidance
- Earnings Report: Seer's Q4 GAAP EPS of -$0.29 beats expectations by $0.03, indicating an improvement in profitability, although the company remains in a loss position.
- Revenue Growth: The Q4 revenue of $4.2M reflects a 5.0% year-over-year increase, yet it falls short of expectations by $0.4M, highlighting challenges in market demand that could impact future investor confidence.
- 2026 Financial Guidance: Seer anticipates full-year 2026 revenue to range between $16 million and $18 million, representing approximately 3% growth at the midpoint compared to 2025, indicating a cautiously optimistic outlook despite slowing growth.
- Market Reaction: While the Q4 EPS exceeded expectations, the revenue miss may lead investors to adopt a cautious stance regarding Seer's future performance, potentially affecting its stock price trajectory.
See More
Seer Inc. Faces Severe Undervaluation Amid Disastrous Operating Results
- Stock Price Collapse: Since its IPO in December 2020, Seer's stock price has plummeted over 96%, indicating a severe loss of shareholder trust under the leadership of Co-Founder and CEO Omid Farokhzad, resulting in significant market value erosion.
- Severe Cash Burn: With a projected revenue midpoint of $17.5 million for 2025, Seer's revenue has only increased by $2 million since 2022, while operational cash burn reached $138.8 million and capital expenditures totaled $11.4 million, leading to a staggering cash use of $150.2 million, meaning over $75 million in cash investment is required for every $1 million of revenue growth.
- Governance Failures: Seer's market capitalization stands at $110.5 million, significantly below its cash reserves of $251.2 million, reflecting a profound mistrust in the Board and management, which has led to ongoing shareholder value destruction.
- Inappropriate Executive Compensation: From 2021 to 2024, Omid Farokhzad's total reported compensation reached $24.9 million, averaging approximately $6 million annually, which is nearly one-third of the company's yearly revenue, as the Board has failed to hold him accountable for poor operational results while continuing to enrich him at the expense of shareholders.
See More
Seer Publishes Large GWAS Study Validating Mass Spectrometry's Role in Proteomics
- Significant Findings: Seer's Proteograph platform detected 5,753 proteins and quantified 1,980 in a GWAS involving approximately 1,600 blood samples, showcasing its robust capabilities in protein research and advancing precision medicine.
- Importance of Validation: The study reveals that about one-third of protein-gene associations reported without mass spectrometry validation do not replicate, underscoring the critical role of mass spectrometry in ensuring the reliability of drug targets and clinical biomarkers, thereby reducing technical noise in research.
- New Discoveries: Among 364 genetic variants associated with protein abundance, 102 were validated in an independent cohort, with 35 being newly reported, thus expanding the knowledge base of genetic regulation of proteins and deepening biomedical research.
- Clinical Impact: By providing more reliable protein measurements, Seer's research lays the groundwork for drug discovery and biomarker development, ensuring that future therapies are built on real biology, which increases the likelihood of success in clinical applications.
See More
