Personalis, Inc. Reports Strong Q4 2025 Earnings and Growth Outlook
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 1 hour ago
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Should l Buy PSNL?
Source: seekingalpha
- Clinical Test Growth: In Q4 2025, Personalis delivered 6,183 clinical tests, representing a 41% sequential growth over Q3 2025 and a 329% year-over-year increase, demonstrating the company's leadership in ultrasensitive MRD testing and robust market demand recovery.
- Revenue and Outlook: The company reported $17.3 million in revenue for Q4, a modest 3% year-over-year increase, while projecting total revenue for 2026 to reach between $78 million and $80 million, reflecting confidence in future growth and strategic market expansion.
- Strategic Expansion: The partnership with Tempus has been strengthened with new coverage for colorectal cancer, and clinical test volumes are expected to reach 43,000 to 45,000 in 2026, indicating a year-over-year growth rate of approximately 170%, which will further solidify market share.
- Financial Health: At the end of 2025, cash and short-term investments totaled $240 million, and while a net loss of approximately $105 million is anticipated for 2026, the company maintains strong cash flow to support future R&D and market expansion.
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Analyst Views on PSNL
Wall Street analysts forecast PSNL stock price to rise
7 Analyst Rating
6 Buy
1 Hold
0 Sell
Strong Buy
Current: 8.310
Low
10.00
Averages
11.17
High
12.00
Current: 8.310
Low
10.00
Averages
11.17
High
12.00
About PSNL
Personalis, Inc. is engaged in developing, marketing and selling advanced cancer genomic tests and analytics. The Company’s advanced genomic sequencing and analytics support the development of personalized cancer vaccines and other cancer immunotherapies. Its products include NeXT Personal, ImmunoI DNeXT, NeXT Personal Dx, NeXT Dx, whole exome sequencing (WES), and whole genome sequencing (WGS). NeXT Personal is a tumor-informed liquid biopsy test for the detection of minimal residual disease (MRD) and recurrence in cancer. NeXT Dx is a comprehensive tumor profiling test that is used to help select therapy for a cancer patient and identify potential clinical trials for a patient. The Company performed WGS on human samples for research projects, such as population sequencing initiatives. The Company’s tests and analytics are used by pharmaceutical companies for translational research, biomarker discovery, and the development of personalized cancer therapies.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Personalis, Inc. Reports Strong Q4 2025 Earnings and Growth Outlook
- Clinical Test Growth: In Q4 2025, Personalis delivered 6,183 clinical tests, representing a 41% sequential growth over Q3 2025 and a 329% year-over-year increase, demonstrating the company's leadership in ultrasensitive MRD testing and robust market demand recovery.
- Revenue and Outlook: The company reported $17.3 million in revenue for Q4, a modest 3% year-over-year increase, while projecting total revenue for 2026 to reach between $78 million and $80 million, reflecting confidence in future growth and strategic market expansion.
- Strategic Expansion: The partnership with Tempus has been strengthened with new coverage for colorectal cancer, and clinical test volumes are expected to reach 43,000 to 45,000 in 2026, indicating a year-over-year growth rate of approximately 170%, which will further solidify market share.
- Financial Health: At the end of 2025, cash and short-term investments totaled $240 million, and while a net loss of approximately $105 million is anticipated for 2026, the company maintains strong cash flow to support future R&D and market expansion.
See More
Personalis (PSNL) Q4 2025 Earnings Call Transcript
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Personalis Q4 Earnings Beat Expectations with Revenue Growth
- Earnings Highlights: Personalis reported a Q4 GAAP EPS of -$0.26, beating expectations by $0.03, indicating an improvement in financial performance despite remaining in the red.
- Revenue Growth: Q4 revenue reached $17.35 million, up 3.3% year-over-year, exceeding market expectations by $0.23 million, demonstrating enhanced competitiveness in the market.
- Surge in Clinical Tests: Clinical test volume surged 41% in Q4 over Q3 to 6,183 tests, with a nearly 400% increase for the full year to 16,233 tests, reflecting strong demand for clinical services.
- Future Guidance: Full-year 2026 revenue guidance is set at $78 to $80 million, below the consensus of $81.68 million, although clinical revenue is expected to grow approximately 5x, indicating a cautious outlook on future growth.
See More
Personalis to Announce Q4 Earnings on February 26th
- Earnings Announcement Date: Personalis (PSNL) is set to release its Q4 earnings report on February 26th after market close, with market participants keenly awaiting the results that could impact stock performance.
- EPS Expectations: The consensus EPS estimate stands at -$0.28, reflecting a 21.7% year-over-year decline, indicating challenges in profitability that may affect investor sentiment.
- Revenue Forecast Adjustments: The anticipated revenue for Q4 is $17.12 million, representing a modest 1.9% year-over-year increase, despite one upward revision and two downward adjustments, suggesting cautious market sentiment regarding the company's growth.
- Future Revenue Guidance: Personalis projects FY 2025 revenue between $69 million and $70 million, demonstrating confidence in future growth prospects, although current earnings data may lead to short-term volatility.
See More
Personalis Gains 10% After Medicare Coverage for NeXT Personal Test
- Medicare Coverage Expansion: Personalis announced that its NeXT Personal cancer recurrence test received Medicare coverage for specific lung cancer cases, which is expected to significantly enhance patient access to testing, particularly for one of the most common cancers in the US.
- Testing Technology Advantage: NeXT Personal is a molecular residual disease test designed to detect traces of circulating tumor DNA, allowing for earlier detection of tumors before standard imaging techniques, thereby improving patient treatment outcomes.
- Market Growth Catalyst: CEO Chris Hall stated that the decision for Medicare coverage will act as a catalyst for the company's continued growth, likely driving future revenue, especially among patients with non-small cell lung cancer.
- Financial Outlook: Personalis expects FY 2025 revenue to be between $69 million and $70 million, reflecting strong market demand and growth potential in the cancer testing sector.
See More
Personalis Secures Medicare Coverage, Stock Rises
- Medicare Coverage Milestone: Personalis's NeXT Personal molecular residual disease test has secured Medicare coverage, which is expected to significantly enhance patient access for lung cancer surveillance, thereby catalyzing the company's growth in the oncology market.
- Clinical Validation Support: The test has demonstrated high accuracy in identifying residual disease through clinical validation from the TRACERx collaboration, tracking up to 1,800 mutations, thus solidifying its role as a reliable tool for monitoring recurrence and residual disease.
- Market Performance Analysis: Although the stock is currently trading 16.6% and 13.7% below its 20-day and 50-day simple moving averages, it is 4.3% and 21.1% above its 100-day and 200-day averages, indicating a strong long-term trend with a 56.29% increase over the past 12 months.
- Analyst Outlook Positive: Analysts have assigned a consensus “Buy” rating with an average price target of $11.78, and Guggenheim recently raised its target to $13.00, reflecting strong market confidence in Personalis's future growth.
See More
Personalis, Inc. Reports Strong Q4 2025 Earnings and Growth Outlook
- Clinical Test Growth: In Q4 2025, Personalis delivered 6,183 clinical tests, representing a 41% sequential growth over Q3 2025 and a 329% year-over-year increase, demonstrating the company's leadership in ultrasensitive MRD testing and robust market demand recovery.
- Revenue and Outlook: The company reported $17.3 million in revenue for Q4, a modest 3% year-over-year increase, while projecting total revenue for 2026 to reach between $78 million and $80 million, reflecting confidence in future growth and strategic market expansion.
- Strategic Expansion: The partnership with Tempus has been strengthened with new coverage for colorectal cancer, and clinical test volumes are expected to reach 43,000 to 45,000 in 2026, indicating a year-over-year growth rate of approximately 170%, which will further solidify market share.
- Financial Health: At the end of 2025, cash and short-term investments totaled $240 million, and while a net loss of approximately $105 million is anticipated for 2026, the company maintains strong cash flow to support future R&D and market expansion.
See More
Personalis (PSNL) Q4 2025 Earnings Call Transcript
See More
Personalis Q4 Earnings Beat Expectations with Revenue Growth
- Earnings Highlights: Personalis reported a Q4 GAAP EPS of -$0.26, beating expectations by $0.03, indicating an improvement in financial performance despite remaining in the red.
- Revenue Growth: Q4 revenue reached $17.35 million, up 3.3% year-over-year, exceeding market expectations by $0.23 million, demonstrating enhanced competitiveness in the market.
- Surge in Clinical Tests: Clinical test volume surged 41% in Q4 over Q3 to 6,183 tests, with a nearly 400% increase for the full year to 16,233 tests, reflecting strong demand for clinical services.
- Future Guidance: Full-year 2026 revenue guidance is set at $78 to $80 million, below the consensus of $81.68 million, although clinical revenue is expected to grow approximately 5x, indicating a cautious outlook on future growth.
See More
Personalis to Announce Q4 Earnings on February 26th
- Earnings Announcement Date: Personalis (PSNL) is set to release its Q4 earnings report on February 26th after market close, with market participants keenly awaiting the results that could impact stock performance.
- EPS Expectations: The consensus EPS estimate stands at -$0.28, reflecting a 21.7% year-over-year decline, indicating challenges in profitability that may affect investor sentiment.
- Revenue Forecast Adjustments: The anticipated revenue for Q4 is $17.12 million, representing a modest 1.9% year-over-year increase, despite one upward revision and two downward adjustments, suggesting cautious market sentiment regarding the company's growth.
- Future Revenue Guidance: Personalis projects FY 2025 revenue between $69 million and $70 million, demonstrating confidence in future growth prospects, although current earnings data may lead to short-term volatility.
See More
Personalis Gains 10% After Medicare Coverage for NeXT Personal Test
- Medicare Coverage Expansion: Personalis announced that its NeXT Personal cancer recurrence test received Medicare coverage for specific lung cancer cases, which is expected to significantly enhance patient access to testing, particularly for one of the most common cancers in the US.
- Testing Technology Advantage: NeXT Personal is a molecular residual disease test designed to detect traces of circulating tumor DNA, allowing for earlier detection of tumors before standard imaging techniques, thereby improving patient treatment outcomes.
- Market Growth Catalyst: CEO Chris Hall stated that the decision for Medicare coverage will act as a catalyst for the company's continued growth, likely driving future revenue, especially among patients with non-small cell lung cancer.
- Financial Outlook: Personalis expects FY 2025 revenue to be between $69 million and $70 million, reflecting strong market demand and growth potential in the cancer testing sector.
See More
Personalis Secures Medicare Coverage, Stock Rises
- Medicare Coverage Milestone: Personalis's NeXT Personal molecular residual disease test has secured Medicare coverage, which is expected to significantly enhance patient access for lung cancer surveillance, thereby catalyzing the company's growth in the oncology market.
- Clinical Validation Support: The test has demonstrated high accuracy in identifying residual disease through clinical validation from the TRACERx collaboration, tracking up to 1,800 mutations, thus solidifying its role as a reliable tool for monitoring recurrence and residual disease.
- Market Performance Analysis: Although the stock is currently trading 16.6% and 13.7% below its 20-day and 50-day simple moving averages, it is 4.3% and 21.1% above its 100-day and 200-day averages, indicating a strong long-term trend with a 56.29% increase over the past 12 months.
- Analyst Outlook Positive: Analysts have assigned a consensus “Buy” rating with an average price target of $11.78, and Guggenheim recently raised its target to $13.00, reflecting strong market confidence in Personalis's future growth.
See More
