NASDAQ 100 Falls 126.91 Points; Active Pre-Market Trading Observed
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 29 2025
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Source: NASDAQ.COM
- Market Dynamics: The NASDAQ 100 index fell by 126.91 points to 25,517.48 in pre-market trading, indicating a weakening market sentiment that could impact investor confidence.
- Volume Analysis: The total pre-market volume reached 79,942,105 shares, suggesting a high level of market activity as investors react sensitively to market fluctuations.
- Stock Performance: Adlai Nortye Ltd. (ANL) rose by $0.43 to $2.07 with a trading volume of 17,448,101 shares, demonstrating strong performance in the market.
- ETF Dynamics: ProShares UltraPro QQQ (TQQQ) declined by $0.76 to $54.55, yet the ETF saw a trading volume of 3,166,584 shares, indicating continued active participation from investors.
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Analyst Views on ANL
About ANL
Adlai Nortye Ltd. is a Cayman Islands-based investment holding company. The Company is involved in the research and development of pharmaceutical products. It is a clinical-stage company focused on the development of targeted and immune-modulating cancer therapies. It is advancing an oncology pipeline, with Buparlisib (AN2025), a pan-phosphoinositide 3-kinase (PI3K) inhibitor, being evaluated in a registrational Phase three trial (NCT04338399) for patients with recurrent or metastatic head and neck squamous cell cancer (HNSCC) that has progressed after prior anti-programmed death-ligand 1 (PD-L1) treatment. It is also advancing multiple drug candidates, including AN4005, an oral small molecule PD-L1 inhibitor; AN8025, a multifunctional fusion protein acting as a T cell and antigen-presenting cell (APC) modulator; and AN9025, an oral small molecule pan-rat sarcoma virus (RAS) inhibitor. The Company’s subsidiary, Alpine Bioscience Ltd. (Alpine BVI), is an investment holding company.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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