MAIA Biotechnology enters clinical supply agreement with BeiGene for THIO
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 07 2025
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Clinical Supply Agreement: MAIA Biotechnology has partnered with BeiGene to conduct Phase 2 trials assessing the efficacy of its anticancer agent THIO in combination with BeiGene's immune checkpoint inhibitor, tislelizumab, across three cancer types: hepatocellular carcinoma, small cell lung cancer, and colorectal cancer.
Preclinical Success and Future Plans: Preclinical studies have shown promising results for THIO, converting non-responsive tumors into responsive ones, and MAIA aims for accelerated FDA approvals while retaining global rights to develop THIO with other agents.
Analyst Views on MAIA
Wall Street analysts forecast MAIA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for MAIA is 14.00 USD with a low forecast of 14.00 USD and a high forecast of 14.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
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Moderate Buy
Current: 2.400
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14.00
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Current: 2.400
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About MAIA
MAIA Biotechnology, Inc. is a clinical-stage biopharmaceutical company developing targeted immunotherapies for cancer. The Company's THIO (6-thio-dG, 6-thio-2'-deoxyguanosine), is a lead asset, is an investigational dual mechanism of action drug candidate incorporating telomere targeting and immunogenicity. The modified nucleotide 6-thio-2-deoxyguanosine (THIO) induces telomerase-dependent telomeric DNA modification, DNA damage responses, and selective cancer cell death. THIO-damaged telomeric fragments accumulate in cytosolic micronuclei and activates both innate (cGAS/STING) and adaptive (T-cell) immune responses. The sequential treatment with THIO followed by PD-(L)1 inhibitors resulted in tumor regression in advanced, in vivo cancer models by induction of cancer type-specific immune memory. THIO is being developed as a second or later line of treatment for NSCLC for patients that have progressed beyond the standard-of-care regimen of existing checkpoint inhibitors.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
