Jazz Pharmaceuticals Reports Ziihera Trial Shows Significant Survival Benefits
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 07 2026
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Source: Benzinga
- Clinical Trial Results: Jazz Pharmaceuticals' Phase 3 HERIZON-GEA-01 trial demonstrated that the doublet therapy of Ziihera plus chemotherapy improved progression-free survival (PFS) by 35%, while the triplet therapy reduced the risk of disease progression or death by approximately 37%, indicating significant clinical relevance.
- Survival Improvement: The triplet therapy achieved a median overall survival (OS) of over two years (26.4 months), marking the longest reported in a Phase 3 trial for GEA, representing more than a seven-month improvement compared to the control arm, thus providing substantial benefits to patients.
- Statistical Trends: The doublet therapy showed a median OS of 24.4 months, with a preliminary trend towards a 20% reduction in death risk, although not statistically significant (p-value of 0.0564), suggesting its potential clinical value.
- Future Analysis Plans: Jazz Pharmaceuticals plans an additional OS interim analysis for Ziihera plus chemotherapy in mid-2026, which may further validate its efficacy and safety, potentially offering new treatment options in the market.
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Analyst Views on JAZZ
Wall Street analysts forecast JAZZ stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for JAZZ is 218.92 USD with a low forecast of 188.00 USD and a high forecast of 263.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
13 Analyst Rating
12 Buy
1 Hold
0 Sell
Strong Buy
Current: 165.410
Low
188.00
Averages
218.92
High
263.00
Current: 165.410
Low
188.00
Averages
218.92
High
263.00
About JAZZ
Jazz Pharmaceuticals plc is a global biopharmaceutical company. It is engaged in developing medicines for people with serious diseases, often with limited or no therapeutic options. It has a diverse portfolio of marketed medicines, including therapies for sleep disorders and epilepsy, and a portfolio of cancer treatments. Its lead-marketed products include Xywav (calcium, magnesium, potassium, and sodium oxybates) oral solution, Epidiolex (cannabidiol) oral solution, Rylaze (asparaginase erwinia chrysanthemi (recombinant)-rywn), Zepzelca (lurbinectedin), Ziihera (zanidatamab-hrii), and Enrylaze (recombinant crisantaspase). Its product candidates include Zanidatamab, Vyxeos, JZP815, JZP898, JZP441, and others. Xywav is used for the treatment of cataplexy or EDS in patients seven years of age and older with narcolepsy. The Company, through Chimerix, Inc., also owns a clinical asset, dordaviprone, a novel small molecule treatment in development for H3 K27M-mutant diffuse glioma.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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