InflaRx Reduces Workforce by 30% to Extend Cash Runway
InflaRx is undertaking measures to reduce spending, extend the Company's cash runway, and align resources to enable further development of izicopan in HS and other I&I indications as a potential best-in-class C5aR inhibitor and pipeline-in-a-product. As part of its strategic focusing, InflaRx is streamlining its organizational structure and largely discontinuing non-essential activities outside the development of izicopan. These actions are designed to sharpen the Company's strategic execution, concentrate resources on its highest-value asset, and materially improve capital efficiency. InflaRx has initiated a workforce reduction of approximately 30% and substantial spending reductions, including significant reductions in Gohibic commercial spending and related functions. The Company estimates these activities will result in a one-time charge of approximately $7M. The majority of this charge will be a non-cash charge related to the write-off of vilobelimab inventory, with a smaller portion associated with the restructuring, including personnel-related costs and the termination or modification of certain third-party contracts. Upon completion, InflaRx expects a significantly leaner cost structure, enabling substantial and sustained reductions in operating expenses and a meaningful extension of its cash runway to mid-2027. InflaRx will maintain the operational capability needed to support the ongoing BARDA "Just Breathe" Phase 2 clinical platform study in ARDS and does not expect these actions to negatively impact the trial. InflaRx will keep Gohibic available for ordering inside the US under its emergency use authorization and maintain the ability to satisfy Gohibic demand in the US on a reactive basis. InflaRx will continue to review partnering opportunities for Gohibic in the US and Europe. In addition, as previously disclosed, the Company anticipates meeting with the FDA to determine a potential development path forward for vilobelimab in pyoderma gangrenosum, which it anticipates would only be conducted in collaboration with a partner. Given data demonstrating its advantageous PK/PD profile, meaningful differentiation as an inhibitor of the C5a/C5aR axis, and potential to address HS, chronic spontaneous urticaria and other I&I indications, the Company will prioritize resource allocation and clinical development toward izicopan while continuing active dialog with potential partners across all geographies to expedite and maximize value. In HS InflaRx continues to make progress toward Phase 2b readiness. InflaRx is in active dialogue with the FDA related to the Phase 2b study design and potential endpoints. The aim is to align on a development path and endpoints expected to meaningfully differentiate izicopan from existing therapies, while also addressing variability inherent in some HS trial outcomes. InflaRx is moving as quickly as is feasible in this effort and intends to provide an update on its HS Phase 2b planning and readiness in due course. InflaRx sees significant potential for izicopan to address unmet needs in multiple I&I indications beyond HS, including CSU, where InflaRx continues data analysis and active dialog with thought leaders to determine next steps. Given the supportive nature of the Phase 2a data collected to-date from the two main CSU dosing cohorts, and low enrollment trends in the third dosing cohort, InflaRx has decided to close the third treatment cohort. InflaRx will utilize the existing data set to determine next steps for izicopan in CSU, which the Company expects to communicate later this year. InflaRx intends to submit the izicopan Phase 2a datasets in HS and CSU for presentation at medical conferences later this year.
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InflaRx to Participate in Investor Conferences
- Investor Conference Schedule: InflaRx will participate in the Guggenheim Securities Biotech Summit on February 11-12, 2026, in New York, conducting one-on-one investor meetings on February 11 to enhance engagement and transparency with investors.
- Virtual Conference Participation: The company will also attend the Oppenheimer 36th Annual Healthcare Life Sciences Conference on February 25-26, 2026, with a virtual presentation on February 25, further expanding its investor base.
- Product Development Progress: InflaRx's lead program, izicopan (INF904), an orally administered small molecule inhibitor, has shown promising pharmacokinetic and pharmacodynamic characteristics in Phase 1 and Phase 2a clinical studies, expected to provide treatment options for various inflammatory diseases.
- Innovative Drug Development: The company has also developed vilobelimab, a first-in-class anti-C5a monoclonal antibody that has demonstrated disease-modifying activity and tolerability in multiple clinical studies, highlighting its innovative potential in anti-inflammatory therapies.

InflaRx Cuts 30% Workforce to Focus on Izicopan Development
- Cost-Cutting Measures: InflaRx announced a 30% workforce reduction and significant cuts to Gohibic-related commercial spending to enhance capital efficiency and support further development of izicopan, expecting a one-time charge of approximately $7 million.
- Cash Flow Outlook: Following the restructuring, InflaRx anticipates its cash runway will extend into mid-2027, and despite reduced spending, it will continue to support the BARDA-sponsored Gohibic clinical trial, ensuring its availability under emergency use authorization in the U.S.
- R&D Priority Shift: The company is prioritizing izicopan, planning to advance its development in hidradenitis suppurativa and other inflammatory and immunology indications, demonstrating a strong commitment to new drug development.
- Market Opportunity Assessment: InflaRx continues to evaluate partnership opportunities for Gohibic in both the U.S. and Europe and plans to engage with the FDA on a potential development path for vilobelimab in pyoderma gangrenosum, showcasing its adaptability in the market.









