HCW Biologics Launches First-in-Human Trial for HW9302
Clinical Trial Initiation: HCW Biologics has commenced a first-in-human clinical trial for HCW9302 at The Ohio State University Wexner Medical Center, targeting alopecia areata, a condition affecting millions globally.
Mechanism of Action: HCW9302 is an interleukin-2 fusion molecule designed to activate and expand regulatory T cells (Treg cells), potentially reducing inflammation without broad immunosuppression.
Significance of Treg Cells: The critical role of Treg cells in controlling immune responses was recently recognized with the 2025 Nobel Prize in Physiology or Medicine, highlighting their importance in preventing autoimmune diseases.
Study Objectives: The Phase 1 study aims to assess the safety and optimal dosing of HCW9302 in up to 30 patients, with secondary goals including evaluating immune cell responses and potential future studies in other inflammatory conditions.
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HCW Biologics Inc. (NASDAQ: HCWB) Engages in Virtual Investor "What This Means" Discussion
Company Overview: HCW Biologics Inc. is a clinical-stage biopharmaceutical company focused on developing novel immunotherapies to combat age-related diseases and chronic inflammation, utilizing their TRBC drug discovery platform.
Product Candidate: The company's lead product, HCW11-040, is a second-generation immune checkpoint inhibitor that combines pembrolizumab with interleukin-7, interleukin-15, and TGF-β receptor components, showing promise in expanding exhausted T cells without side effects.
Upcoming Presentation: HCW Biologics will present data on HCW11-040 at the 40th annual meeting of the Society for Immunotherapy of Cancer (SITC) on November 8, 2025, highlighting its potential as a novel tetra-specific immunotherapeutic.
Forward-Looking Statements: The company has issued forward-looking statements regarding the efficacy of its pembrolizumab-based TRBC fusion molecules, acknowledging the inherent risks and uncertainties in achieving anticipated results.
HCW Biologics Scientists to Showcase Three Posters at the 40th Annual Society for Immunotherapy of Cancer Meeting
Company Overview: HCW Biologics Inc. is a clinical-stage biopharmaceutical company focused on developing innovative immunotherapies targeting chronic inflammation and related diseases, with a proprietary TRBC platform for creating various immunotherapeutic compounds.
Upcoming Presentations: The company will present three posters at the 40th Annual Meeting of the Society for Immunotherapy of Cancer from November 5 to 9, 2025, showcasing their lead drug candidates and their potential applications in cancer therapy.