Galectin Therapeutics showcases NAVIGATE trial findings at AASLD
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 10 2025
0mins
Should l Buy GALT?
Presentation at AASLD: Galectin Therapeutics will present findings from the NAVIGATE study at the AASLD 2025 Annual Meeting, focusing on the analysis of belapectin in patients with compensated MASH cirrhosis and portal hypertension.
NAVIGATE Trial Overview: The Phase 2b NAVIGATE trial was a randomized, double-blind, placebo-controlled study involving 355 patients, assessing the efficacy of belapectin, a galectin-3 inhibitor, administered intravenously over 18 months.
Dosage and Administration: Patients were randomized to receive either 2 mg/kg or 4 mg/kg of belapectin or a placebo every other week, with the study designed to evaluate the drug's impact on liver complications.
Efficacy Results: Belapectin 2 mg/kg showed a lower incidence of new varices across all fibrosis categories, particularly benefiting patients with an Enhanced Liver Fibrosis score greater than 11.3, indicating a higher risk for liver complications.
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Analyst Views on GALT
Wall Street analysts forecast GALT stock price to rise
1 Analyst Rating
1 Buy
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0 Sell
Moderate Buy
Current: 3.010
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11.00
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11.00
High
11.00
Current: 3.010
Low
11.00
Averages
11.00
High
11.00
About GALT
Galectin Therapeutics, Inc. is a clinical-stage biopharmaceutical company dedicated to developing therapies to improve the lives of patients with chronic liver disease and cancer. The Company’s drug candidates are based on its method of targeting galectin proteins, which are key mediators of biologic and pathologic functions. The Company’s lead drug, belapectin, is a carbohydrate-based drug that inhibits the galectin-3 protein, which is directly involved in multiple inflammatory, fibrotic, and malignant diseases for which it has Fast Track designation by the U.S. Food and Drug Administration. The lead development program is in metabolic dysfunction-associated steatohepatitis (MASH, formerly known as nonalcoholic steatohepatitis, or NASH) with cirrhosis, the most advanced form of MASH-related fibrosis. The Company's additional development programs are in the treatment of combination immunotherapy for advanced head and neck cancers and other malignancies.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Investigation Launched: Pomerantz LLP is investigating Galectin Therapeutics Inc. and its executives for potential securities fraud or other unlawful business practices, which could undermine investor confidence and lead to further stock volatility.
- FDA Response: On December 19, 2025, Galectin announced that the FDA provided a written response to its meeting request regarding the belapectin development program, indicating alignment on the proposed patient population for a registration trial, but unresolved key aspects of the trial design may delay clinical trial progress.
- Stock Price Drop: Following the FDA news, Galectin's stock price fell by $1.78, or 28.9%, closing at $4.38 per share, reflecting market concerns and diminished confidence in the company's future prospects.
- Legal Matters: Pomerantz LLP, a prominent securities class action law firm, has been advocating for the rights of securities fraud victims for over 85 years; unfavorable investigation outcomes could lead to significant damages against the company, further impacting its financial health.
See More
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- Securities Fraud Investigation: Pomerantz LLP is investigating Galectin Therapeutics and its executives for potential securities fraud and other unlawful business practices, which could undermine investor confidence and lead to stock volatility.
- FDA Meeting Update: On December 19, 2025, Galectin announced that the FDA provided a written response to its Type C meeting request regarding the development program for belapectin, indicating alignment on the patient population but leaving key trial design aspects unresolved.
- Stock Price Plunge: Following the FDA news, Galectin's stock price fell by $1.78, or 28.9%, closing at $4.38 per share, reflecting market concerns about the company's future prospects.
- Legal Background: Pomerantz LLP, a prominent securities class action law firm with over 85 years of experience, focuses on advocating for victims of securities fraud and corporate misconduct, potentially offering legal support to affected investors.
See More
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- Change in FDA Communication: The FDA's conversion of Galectin's request for an in-person or teleconference meeting into a written response highlights unresolved issues in key trial design aspects, which may impact the progress of its clinical trials and registration applications.
- Follow-Up Meeting Plans: Galectin plans to pursue a follow-up Type C meeting to finalize remaining components of its clinical trial design, and while there is alignment with the FDA on the proposed patient population, unresolved key design issues could delay trial progress.
- Legal Investigation Initiated: Pomerantz LLP is investigating whether Galectin and its executives have engaged in securities fraud or other unlawful business practices, potentially exposing investors to further legal risks and financial losses.
See More
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- Securities Fraud Investigation: Pomerantz LLP is investigating whether Galectin Therapeutics has engaged in securities fraud or other unlawful business practices, which could undermine investor confidence and lead to further declines in stock price.
- FDA Communication Change: On December 19, 2025, Galectin announced that the FDA converted its initial request for an in-person meeting to a written response, indicating alignment on the proposed patient population for a registration trial, yet unresolved key aspects of trial design may delay clinical trial progress.
- Stock Price Volatility: Following the FDA news, Galectin's stock price fell by $1.78, or 28.9%, closing at $4.38 per share, reflecting market concerns regarding the company's future prospects.
- Potential Legal Consequences: Pomerantz LLP, recognized for its expertise in securities litigation, may initiate a class action against Galectin if the investigation confirms misconduct, which would severely impact the company's reputation and financial standing.
See More
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- Change in FDA Communication: The FDA converted the company's initial request for an in-person or teleconference meeting into a written response, and while there is alignment on the proposed patient population for a registration trial, unresolved key aspects of the trial design may hinder future clinical progress.
- Legal Investigation Initiated: Pomerantz LLP is investigating whether Galectin and its executives have engaged in securities fraud or other unlawful business practices, which could expose the company to legal risks and further impact shareholder confidence.
- Increased Investor Scrutiny: The sharp stock decline and the initiation of a legal investigation have significantly heightened investor attention on Galectin, potentially leading to more investors seeking to join class action lawsuits to protect their interests.
See More
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- FDA Communication Shift: The FDA converted Galectin's initial request for an in-person or teleconference meeting into a written response, suggesting uncertainties in the company's trial design that could impact its development timeline.
- Follow-Up Meeting Plans: The company intends to pursue a follow-up Type C meeting to address key aspects of its trial design, which may influence future clinical trial outcomes and market confidence.
- Legal Investigation Initiated: The Schall Law Firm is investigating potential violations of securities laws by Galectin, which could lead to further losses for investors and trigger potential class action lawsuits.
See More
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- Investigation Launched: Pomerantz LLP is investigating Galectin Therapeutics Inc. and its executives for potential securities fraud or other unlawful business practices, which could undermine investor confidence and lead to further stock volatility.
- FDA Response: On December 19, 2025, Galectin announced that the FDA provided a written response to its meeting request regarding the belapectin development program, indicating alignment on the proposed patient population for a registration trial, but unresolved key aspects of the trial design may delay clinical trial progress.
- Stock Price Drop: Following the FDA news, Galectin's stock price fell by $1.78, or 28.9%, closing at $4.38 per share, reflecting market concerns and diminished confidence in the company's future prospects.
- Legal Matters: Pomerantz LLP, a prominent securities class action law firm, has been advocating for the rights of securities fraud victims for over 85 years; unfavorable investigation outcomes could lead to significant damages against the company, further impacting its financial health.
See More
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- Securities Fraud Investigation: Pomerantz LLP is investigating Galectin Therapeutics and its executives for potential securities fraud and other unlawful business practices, which could undermine investor confidence and lead to stock volatility.
- FDA Meeting Update: On December 19, 2025, Galectin announced that the FDA provided a written response to its Type C meeting request regarding the development program for belapectin, indicating alignment on the patient population but leaving key trial design aspects unresolved.
- Stock Price Plunge: Following the FDA news, Galectin's stock price fell by $1.78, or 28.9%, closing at $4.38 per share, reflecting market concerns about the company's future prospects.
- Legal Background: Pomerantz LLP, a prominent securities class action law firm with over 85 years of experience, focuses on advocating for victims of securities fraud and corporate misconduct, potentially offering legal support to affected investors.
See More
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- Significant Stock Decline: Galectin Therapeutics experienced a stock price drop of $1.78, or 28.9%, closing at $4.38 per share following the FDA's response regarding its belapectin clinical trial, indicating market concerns about the company's future prospects.
- Change in FDA Communication: The FDA's conversion of Galectin's request for an in-person or teleconference meeting into a written response highlights unresolved issues in key trial design aspects, which may impact the progress of its clinical trials and registration applications.
- Follow-Up Meeting Plans: Galectin plans to pursue a follow-up Type C meeting to finalize remaining components of its clinical trial design, and while there is alignment with the FDA on the proposed patient population, unresolved key design issues could delay trial progress.
- Legal Investigation Initiated: Pomerantz LLP is investigating whether Galectin and its executives have engaged in securities fraud or other unlawful business practices, potentially exposing investors to further legal risks and financial losses.
See More
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- Securities Fraud Investigation: Pomerantz LLP is investigating whether Galectin Therapeutics has engaged in securities fraud or other unlawful business practices, which could undermine investor confidence and lead to further declines in stock price.
- FDA Communication Change: On December 19, 2025, Galectin announced that the FDA converted its initial request for an in-person meeting to a written response, indicating alignment on the proposed patient population for a registration trial, yet unresolved key aspects of trial design may delay clinical trial progress.
- Stock Price Volatility: Following the FDA news, Galectin's stock price fell by $1.78, or 28.9%, closing at $4.38 per share, reflecting market concerns regarding the company's future prospects.
- Potential Legal Consequences: Pomerantz LLP, recognized for its expertise in securities litigation, may initiate a class action against Galectin if the investigation confirms misconduct, which would severely impact the company's reputation and financial standing.
See More
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- Significant Stock Drop: Galectin Therapeutics experienced a stock price decline of $1.78, or 28.9%, closing at $4.38 per share following the FDA's feedback on its belapectin clinical trial design, indicating market concerns about the company's future prospects.
- Change in FDA Communication: The FDA converted the company's initial request for an in-person or teleconference meeting into a written response, and while there is alignment on the proposed patient population for a registration trial, unresolved key aspects of the trial design may hinder future clinical progress.
- Legal Investigation Initiated: Pomerantz LLP is investigating whether Galectin and its executives have engaged in securities fraud or other unlawful business practices, which could expose the company to legal risks and further impact shareholder confidence.
- Increased Investor Scrutiny: The sharp stock decline and the initiation of a legal investigation have significantly heightened investor attention on Galectin, potentially leading to more investors seeking to join class action lawsuits to protect their interests.
See More
Galectin Therapeutics Shares Plunge 28.9% Following FDA Response on Belapectin Development
- Stock Price Plunge: Following Galectin Therapeutics' announcement regarding the FDA's response to its belapectin development program, shares fell by 28.9% on the same day, indicating investor concerns about the company's future prospects.
- FDA Communication Shift: The FDA converted Galectin's initial request for an in-person or teleconference meeting into a written response, suggesting uncertainties in the company's trial design that could impact its development timeline.
- Follow-Up Meeting Plans: The company intends to pursue a follow-up Type C meeting to address key aspects of its trial design, which may influence future clinical trial outcomes and market confidence.
- Legal Investigation Initiated: The Schall Law Firm is investigating potential violations of securities laws by Galectin, which could lead to further losses for investors and trigger potential class action lawsuits.
See More
