Galectin Therapeutics showcases NAVIGATE trial findings at AASLD
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 10 2025
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Presentation at AASLD: Galectin Therapeutics will present findings from the NAVIGATE study at the AASLD 2025 Annual Meeting, focusing on the analysis of belapectin in patients with compensated MASH cirrhosis and portal hypertension.
NAVIGATE Trial Overview: The Phase 2b NAVIGATE trial was a randomized, double-blind, placebo-controlled study involving 355 patients, assessing the efficacy of belapectin, a galectin-3 inhibitor, administered intravenously over 18 months.
Dosage and Administration: Patients were randomized to receive either 2 mg/kg or 4 mg/kg of belapectin or a placebo every other week, with the study designed to evaluate the drug's impact on liver complications.
Efficacy Results: Belapectin 2 mg/kg showed a lower incidence of new varices across all fibrosis categories, particularly benefiting patients with an Enhanced Liver Fibrosis score greater than 11.3, indicating a higher risk for liver complications.
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Analyst Views on GALT
Wall Street analysts forecast GALT stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for GALT is 11.00 USD with a low forecast of 11.00 USD and a high forecast of 11.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
1 Analyst Rating
1 Buy
0 Hold
0 Sell
Moderate Buy
Current: 2.930
Low
11.00
Averages
11.00
High
11.00
Current: 2.930
Low
11.00
Averages
11.00
High
11.00
About GALT
Galectin Therapeutics, Inc. is a clinical-stage biopharmaceutical company dedicated to developing therapies to improve the lives of patients with chronic liver disease and cancer. The Company’s drug candidates are based on its method of targeting galectin proteins, which are key mediators of biologic and pathologic functions. The Company’s lead drug, belapectin, is a carbohydrate-based drug that inhibits the galectin-3 protein, which is directly involved in multiple inflammatory, fibrotic, and malignant diseases for which it has Fast Track designation by the U.S. Food and Drug Administration. The lead development program is in metabolic dysfunction-associated steatohepatitis (MASH, formerly known as nonalcoholic steatohepatitis, or NASH) with cirrhosis, the most advanced form of MASH-related fibrosis. The Company's additional development programs are in the treatment of combination immunotherapy for advanced head and neck cancers and other malignancies.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Galectin Therapeutics Under Investigation, Stock Plummets 28.9%
- Investigation Launched: Pomerantz LLP is investigating Galectin Therapeutics Inc. and its executives for potential securities fraud or other unlawful business practices, which could undermine investor confidence and lead to further stock volatility.
- FDA Response: On December 19, 2025, Galectin announced that the FDA provided a written response to its meeting request regarding the belapectin development program, indicating alignment on the proposed patient population for a registration trial, but unresolved key aspects of the trial design may delay clinical trial progress.
- Stock Price Drop: Following the FDA news, Galectin's stock price fell by $1.78, or 28.9%, closing at $4.38 per share, reflecting market concerns and diminished confidence in the company's future prospects.
- Legal Matters: Pomerantz LLP, a prominent securities class action law firm, has been advocating for the rights of securities fraud victims for over 85 years; unfavorable investigation outcomes could lead to significant damages against the company, further impacting its financial health.
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Galectin Therapeutics Under Investigation, Stock Plummets 28.9%
- Securities Fraud Investigation: Pomerantz LLP is investigating Galectin Therapeutics and its executives for potential securities fraud and other unlawful business practices, which could undermine investor confidence and lead to stock volatility.
- FDA Meeting Update: On December 19, 2025, Galectin announced that the FDA provided a written response to its Type C meeting request regarding the development program for belapectin, indicating alignment on the patient population but leaving key trial design aspects unresolved.
- Stock Price Plunge: Following the FDA news, Galectin's stock price fell by $1.78, or 28.9%, closing at $4.38 per share, reflecting market concerns about the company's future prospects.
- Legal Background: Pomerantz LLP, a prominent securities class action law firm with over 85 years of experience, focuses on advocating for victims of securities fraud and corporate misconduct, potentially offering legal support to affected investors.
Continue Reading