Company Reports Q1 Revenue of $64.86M, Below Expectations
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Apr 30 2026
0mins
Should l Buy SNDX?
Reports Q1 revenue $64.86M, consensus $69.83M. "We delivered over $100 million in combined Revuforj and Niktimvo net sales in the first quarter, highlighting strong demand for our medicines and advancing the company towards profitability. Revuforj net revenue totaled $49 million, underscoring our leadership in menin inhibition and strong adoption in both R/R NPM1m AML and KMT2Ar acute leukemia. Notably, recent analysis indicates that Revuforj is enabling nearly half of KMT2A patients to receive a stem cell transplant, providing the best chance for durable remission and positioning the franchise for long-term growth as an increasing number of patients return to therapy post-transplant," said Michael A. Metzger, Chief Executive Officer. "We are poised for continued commercial growth with robust prescriber bases, excellent payer coverage, and multiple evolving treatment patterns that should extend the average duration of treatment for both medicines."
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Analyst Views on SNDX
Wall Street analysts forecast SNDX stock price to rise
10 Analyst Rating
10 Buy
0 Hold
0 Sell
Strong Buy
Current: 20.540
Low
27.00
Averages
39.11
High
56.00
Current: 20.540
Low
27.00
Averages
39.11
High
56.00
About SNDX
Syndax Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. It is focused on developing a pipeline of cancer therapies. Its product candidates include Revuforj and Niktimvo. It is developing Revuforj, a potent, selective, small molecule inhibitor of the menin-MLL binding interaction for the treatment of KMT2A rearranged also known as mixed lineage leukemia rearranged, acute leukemias including acute lymphoblastic leukemia and acute myeloid leukemia (AML), and necleophosmin 1, also known as NPM1, mutant AML. It is also exploring the use of Revuforj as a treatment in solid tumors, specifically its activity in metastatic colorectal cancer. It is also developing Niktimvo, a monoclonal antibody that blocks the colony stimulating factor 1 receptor (CSF-1R) in chronic graft-versus-host disease (cGVHD), as well as idiopathic pulmonary fibrosis. Entinostat is its oral, small molecule product candidate that has direct effects on both cancer cells and immune regulatory cells.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Syndax Pharmaceuticals Q1 2026 Earnings Call Highlights
- Strong Sales Performance: Syndax Pharmaceuticals achieved over $100 million in combined sales of Revuforj and Niktimvo in Q1 2026, demonstrating robust demand for both medicines and advancing the company towards profitability.
- Revuforj Revenue Growth: Revuforj net revenue reached $49 million, significantly increasing the estimate of KMT2A patients able to receive potentially curative stem cell transplants to nearly 50%, up from the previous estimate of 33%, indicating improved treatment efficacy.
- Stable Niktimvo Performance: Niktimvo delivered $55 million in net revenue in Q1, reflecting consistent new patient starts despite natural attrition, suggesting strong ongoing market demand.
- Sufficient Funding: As of March 31, 2026, the company reported $352.1 million in cash, cash equivalents, and marketable securities, ensuring the ability to continue investing in its R&D and commercial priorities.
See More
Syndax Pharmaceuticals Q1 Earnings Beat Expectations
- Earnings Highlights: Syndax Pharmaceuticals reported a Q1 GAAP EPS of -$0.48, beating expectations by $0.13, indicating an improving trend in the company's profitability.
- Revenue Surge: The company achieved revenue of $64.9 million in Q1, representing a remarkable year-over-year growth of 223.9%, although it fell short of expectations, reflecting strong market demand for its products.
- Expense Forecast: For the full year 2026, total research and development plus selling, general, and administrative expenses are expected to be approximately $400 million, excluding an estimated $50 million in non-cash stock compensation, highlighting the company's ongoing investment in business expansion.
- Market Outlook: Despite missing revenue expectations, Syndax's robust growth momentum and upcoming drug launches may attract investor interest and enhance market confidence.
See More
Syndax Pharmaceuticals to Report Q1 2026 Financial Results
- Earnings Release Schedule: Syndax Pharmaceuticals is set to announce its Q1 2026 financial results on April 30, 2026, which is expected to significantly impact investor sentiment.
- Conference Call Details: Management will host a conference call and live audio webcast at 4:30 p.m. ET on the same day, providing investors with direct access to company updates and enhancing transparency.
- Replay Availability: For those unable to attend the live session, a replay will be accessible approximately 24 hours post-call and will remain available for 90 days, ensuring widespread dissemination of critical information.
- Pipeline Highlights: Syndax's pipeline features FDA-approved cancer therapies like Revuforj® and Niktimvo™, showcasing the company's ongoing commitment and potential in cancer treatment, which may attract increased investor interest.
See More
DAFNA Capital Reduces Stake in Syndax Pharmaceuticals
- Share Reduction Details: DAFNA Capital reported in its February 17, 2026 SEC filing that it sold 222,847 shares of Syndax Pharmaceuticals in Q4, with an estimated transaction value of $3.89 million, reflecting a cautious outlook on the company's future performance.
- Ownership Percentage Change: Following the sale, DAFNA's stake in Syndax decreased to 1.36% from 1.90% in the previous quarter, indicating a strategic adjustment in its investment portfolio.
- Market Performance Comparison: As of last Friday, Syndax's stock price stood at $24.23, marking a 72% increase over the past year, significantly outperforming the S&P 500's 15% rise during the same period, highlighting its strong position in the biopharmaceutical sector.
- Company Growth Prospects: Syndax focuses on developing oncology therapies, and despite facing high operating costs and ongoing losses, its $172 million in 2025 sales and rapidly scaling commercial products demonstrate its potential in transitioning from clinical to commercial-stage biotech.
See More
DAFNA Capital Management Reduces SNDX Holdings
- Share Reduction Details: DAFNA Capital Management sold 222,847 shares of Syndax Pharmaceuticals (SNDX) in Q4, with an estimated transaction value of approximately $3.89 million, indicating a cautious stance towards the stock.
- Position Value Decline: The value of DAFNA's SNDX holdings decreased by $1.87 million by quarter-end, reflecting both trading activities and price movements, with the current position representing 1.4% of reportable AUM.
- Company Overview: Syndax Pharmaceuticals focuses on developing novel cancer therapies, generating approximately $172 million in sales for 2025, showcasing a successful transition from clinical to commercial stages, albeit with higher operating costs and ongoing losses.
- Investor Caution: Despite Syndax's innovative potential in the biopharmaceutical sector, it was not included in the current top investment stock list by analysts, advising investors to carefully consider market volatility before making decisions.
See More
Kynam Capital Management Reduces Syndax Holdings
- Share Reduction Details: Kynam Capital Management disclosed in a February 17, 2026 SEC filing that it sold 469,041 shares of Syndax Pharmaceuticals, valued at approximately $8.18 million, indicating a cautious stance towards the company's future prospects.
- Position Percentage Change: Following the sale, Syndax now accounts for 10.81% of Kynam's reportable assets, reflecting a significant yet measured adjustment in their holdings, which still signals confidence in the company's long-term potential.
- Company Financial Performance: Syndax Pharmaceuticals has seen its stock price surge 72% over the past year, achieving a market capitalization of $2.1 billion and total revenue of $172.4 million, despite a net loss of $285.4 million, highlighting the tension between growth and profitability.
- Market Reaction Analysis: The successful launch of new therapies has driven revenue growth for Syndax, particularly with Revuforj contributing approximately $124.8 million, although the company continues to face high R&D and commercialization costs, necessitating investor attention on its path to profitability.
See More
Syndax Pharmaceuticals Q1 2026 Earnings Call Highlights
- Strong Sales Performance: Syndax Pharmaceuticals achieved over $100 million in combined sales of Revuforj and Niktimvo in Q1 2026, demonstrating robust demand for both medicines and advancing the company towards profitability.
- Revuforj Revenue Growth: Revuforj net revenue reached $49 million, significantly increasing the estimate of KMT2A patients able to receive potentially curative stem cell transplants to nearly 50%, up from the previous estimate of 33%, indicating improved treatment efficacy.
- Stable Niktimvo Performance: Niktimvo delivered $55 million in net revenue in Q1, reflecting consistent new patient starts despite natural attrition, suggesting strong ongoing market demand.
- Sufficient Funding: As of March 31, 2026, the company reported $352.1 million in cash, cash equivalents, and marketable securities, ensuring the ability to continue investing in its R&D and commercial priorities.
See More
Syndax Pharmaceuticals Q1 Earnings Beat Expectations
- Earnings Highlights: Syndax Pharmaceuticals reported a Q1 GAAP EPS of -$0.48, beating expectations by $0.13, indicating an improving trend in the company's profitability.
- Revenue Surge: The company achieved revenue of $64.9 million in Q1, representing a remarkable year-over-year growth of 223.9%, although it fell short of expectations, reflecting strong market demand for its products.
- Expense Forecast: For the full year 2026, total research and development plus selling, general, and administrative expenses are expected to be approximately $400 million, excluding an estimated $50 million in non-cash stock compensation, highlighting the company's ongoing investment in business expansion.
- Market Outlook: Despite missing revenue expectations, Syndax's robust growth momentum and upcoming drug launches may attract investor interest and enhance market confidence.
See More
Syndax Pharmaceuticals to Report Q1 2026 Financial Results
- Earnings Release Schedule: Syndax Pharmaceuticals is set to announce its Q1 2026 financial results on April 30, 2026, which is expected to significantly impact investor sentiment.
- Conference Call Details: Management will host a conference call and live audio webcast at 4:30 p.m. ET on the same day, providing investors with direct access to company updates and enhancing transparency.
- Replay Availability: For those unable to attend the live session, a replay will be accessible approximately 24 hours post-call and will remain available for 90 days, ensuring widespread dissemination of critical information.
- Pipeline Highlights: Syndax's pipeline features FDA-approved cancer therapies like Revuforj® and Niktimvo™, showcasing the company's ongoing commitment and potential in cancer treatment, which may attract increased investor interest.
See More
DAFNA Capital Reduces Stake in Syndax Pharmaceuticals
- Share Reduction Details: DAFNA Capital reported in its February 17, 2026 SEC filing that it sold 222,847 shares of Syndax Pharmaceuticals in Q4, with an estimated transaction value of $3.89 million, reflecting a cautious outlook on the company's future performance.
- Ownership Percentage Change: Following the sale, DAFNA's stake in Syndax decreased to 1.36% from 1.90% in the previous quarter, indicating a strategic adjustment in its investment portfolio.
- Market Performance Comparison: As of last Friday, Syndax's stock price stood at $24.23, marking a 72% increase over the past year, significantly outperforming the S&P 500's 15% rise during the same period, highlighting its strong position in the biopharmaceutical sector.
- Company Growth Prospects: Syndax focuses on developing oncology therapies, and despite facing high operating costs and ongoing losses, its $172 million in 2025 sales and rapidly scaling commercial products demonstrate its potential in transitioning from clinical to commercial-stage biotech.
See More
DAFNA Capital Management Reduces SNDX Holdings
- Share Reduction Details: DAFNA Capital Management sold 222,847 shares of Syndax Pharmaceuticals (SNDX) in Q4, with an estimated transaction value of approximately $3.89 million, indicating a cautious stance towards the stock.
- Position Value Decline: The value of DAFNA's SNDX holdings decreased by $1.87 million by quarter-end, reflecting both trading activities and price movements, with the current position representing 1.4% of reportable AUM.
- Company Overview: Syndax Pharmaceuticals focuses on developing novel cancer therapies, generating approximately $172 million in sales for 2025, showcasing a successful transition from clinical to commercial stages, albeit with higher operating costs and ongoing losses.
- Investor Caution: Despite Syndax's innovative potential in the biopharmaceutical sector, it was not included in the current top investment stock list by analysts, advising investors to carefully consider market volatility before making decisions.
See More
Kynam Capital Management Reduces Syndax Holdings
- Share Reduction Details: Kynam Capital Management disclosed in a February 17, 2026 SEC filing that it sold 469,041 shares of Syndax Pharmaceuticals, valued at approximately $8.18 million, indicating a cautious stance towards the company's future prospects.
- Position Percentage Change: Following the sale, Syndax now accounts for 10.81% of Kynam's reportable assets, reflecting a significant yet measured adjustment in their holdings, which still signals confidence in the company's long-term potential.
- Company Financial Performance: Syndax Pharmaceuticals has seen its stock price surge 72% over the past year, achieving a market capitalization of $2.1 billion and total revenue of $172.4 million, despite a net loss of $285.4 million, highlighting the tension between growth and profitability.
- Market Reaction Analysis: The successful launch of new therapies has driven revenue growth for Syndax, particularly with Revuforj contributing approximately $124.8 million, although the company continues to face high R&D and commercialization costs, necessitating investor attention on its path to profitability.
See More
