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SNDX Should I Buy

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Intellectia

Should You Buy Syndax Pharmaceuticals Inc (SNDX) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Hold
Latest Price
23.780
1 Day change
-1.86%
52 Week Range
25.590
Analysis Updated At
2026/04/17
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Syndax Pharmaceuticals Inc (SNDX) does not present a compelling buy opportunity for a beginner, long-term investor at this time. While the stock has some positive catalysts, the technical indicators, financial performance, and lack of strong trading signals suggest a cautious approach. The investor's impatience and unwillingness to wait for optimal entry points further support a 'hold' recommendation.

Technical Analysis

The stock's technical indicators are mixed. The MACD is negative and expanding downward, indicating bearish momentum. RSI is neutral at 38.784, providing no clear signal. However, moving averages are bullish (SMA_5 > SMA_20 > SMA_200), and the stock is trading near its pivot level of 24.402, with resistance at 25.289 and support at 23.516.

Options Data

Bullish
Open Interest Put-Call Ratio
Bullish
Option Volume Put-Call Ratio

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
7
Buy
5

Positive Catalysts

  • The upcoming Phase 2 data for axatilimab in idiopathic pulmonary fibrosis and strong early launch metrics for Revuforj in leukemia provide potential upside.

Neutral/Negative Catalysts

  • The stock's recent trend indicates a 60% chance of declining -2.92% in the next week and -5.45% in the next month. Additionally, the financials show a significant net income drop of -27.77% YoY and EPS decline of -28.44% YoY, despite a strong revenue increase. No recent news or congress trading data to act as immediate catalysts.

Financial Performance

In Q4 2025, revenue increased significantly by 794.90% YoY to $68.73M, but net income dropped by -27.77% YoY to -$68.01M, and EPS fell by -28.44% YoY to -0.78. Gross margin improved to 96.06%, up 7.64% YoY, indicating strong operational efficiency despite profitability challenges.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

Analyst sentiment is positive overall, with multiple firms maintaining Buy or Outperform ratings. Price targets range from $28 to $57, reflecting confidence in the company's pipeline, particularly in idiopathic pulmonary fibrosis and leukemia treatments.

Wall Street analysts forecast SNDX stock price to rise
10 Analyst Rating
Wall Street analysts forecast SNDX stock price to rise
10 Buy
0 Hold
0 Sell
Strong Buy
Current: 24.230
sliders
Low
27
Averages
39.11
High
56
Current: 24.230
sliders
Low
27
Averages
39.11
High
56
Mizuho
Outperform
to
Outperform
downgrade
$45 -> $43
AI Analysis
2026-03-31
Reason
Mizuho
Price Target
$45 -> $43
AI Analysis
2026-03-31
downgrade
Outperform
to
Outperform
Reason
Mizuho lowered the firm's price target on Syndax to $43 from $45 and keeps an Outperform rating on the shares. The firm updated models in the small-cap biotech space following the Q4 reports.
Goldman Sachs
Corinne Johnson
Buy
maintain
$28 -> $34
2026-03-31
Reason
Goldman Sachs
Corinne Johnson
Price Target
$28 -> $34
2026-03-31
maintain
Buy
Reason
Goldman Sachs analyst Corinne Johnson raised the firm's price target on Syndax to $34 from $28 and keeps a Buy rating on the shares. Ahead of Syndax's Phase 2 data for axatilimab in idiopathic pulmonary fibrosis expected in 4Q26, peak sales estimates have been increased by $325M on a risk-adjusted basis, reflecting growing focus on the program, the analyst tells investors in a research note. While Revuforj in relapsed/refractory leukemias remains central to the story, early launch metrics in KMT2A- and NPM1-mutated AML appear strong, and the mechanistic rationale for CSF-1R inhibition in IPF supports confidence in the program's potential path to Phase 3 success, the firm says.
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