Chevron Analyst Becomes Optimistic; Check Out the Top 5 Upgrades for Monday
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 01 2025
0mins
Should l Buy NMRA?
Source: Benzinga
Analyst Upgrades: Several Wall Street analysts have upgraded their ratings on various companies, including Neumora Therapeutics, Old Dominion Freight Line, Toast Inc, Chevron Corp, and Spyre Therapeutics.
Neumora Therapeutics: RBC Capital upgraded Neumora Therapeutics from Sector Perform to Outperform, raising the price target from $4 to $7, while shares closed at $2.24.
Old Dominion Freight Line: BMO Capital upgraded Old Dominion Freight Line from Market Perform to Outperform, lowering the price target from $172 to $170, with shares closing at $135.29.
Chevron Corp and Others: HSBC upgraded Chevron from Hold to Buy with a price target increase from $166 to $169, and other companies like Toast and Spyre Therapeutics also received positive upgrades from analysts.
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Analyst Views on NMRA
Wall Street analysts forecast NMRA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for NMRA is 9.33 USD with a low forecast of 3.00 USD and a high forecast of 18.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
8 Analyst Rating
5 Buy
2 Hold
1 Sell
Moderate Buy
Current: 2.020
Low
3.00
Averages
9.33
High
18.00
Current: 2.020
Low
3.00
Averages
9.33
High
18.00
About NMRA
Neumora Therapeutics Inc. is a clinical-stage biopharmaceutical company. The Company's therapeutic pipeline consists of seven clinical and preclinical neuroscience programs that target novel mechanisms of action for a broad range of underserved neuropsychiatric disorders and neurodegenerative diseases. Its advanced product candidate, navacaprant (NMRA-140), is a novel once-daily oral kappa opioid receptor (KOR) antagonist that is being developed for the treatment of depressive disorder (MDD). Navacaprant is being investigated in the KOASTAL pivotal Phase 3 program, evaluating navacaprant monotherapy in patients with moderate to severe MDD. The Company's next advanced product candidate is NMRA-511, which is a highly selective, novel antagonist of the vasopressin 1a receptor (V1aR) being developed for the treatment of agitation associated with dementia due to Alzheimer's disease (AD).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Significant Clinical Effect: In the Phase 1b study targeting Alzheimer’s patients, NMRA-511 showed a placebo-adjusted change of -2.6 and -2.1 in CMAI total scores at Weeks 6 and 8, respectively, indicating its clinically meaningful impact on reducing agitation behaviors.
- Favorable Safety Profile: NMRA-511 demonstrated good tolerability and safety, with treatment-emergent adverse events (TEAEs) typically mild to moderate, and a low discontinuation rate of only 2.5% due to TEAEs, establishing a solid foundation for future clinical applications.
- Clear Next Steps: Neumora plans to launch a multiple ascending dose extension study at higher doses in 2026, develop an extended-release formulation for once-daily dosing, and initiate a Phase 2/3 dose-ranging study, reflecting strong confidence in NMRA-511's long-term development.
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