Can-Fite Secures Patent for Namodenoson-Based Weight Loss Drug
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Mar 17 2026
0mins
Should l Buy CANF?
Can-Fite BioPharma announced that the Israeli Patent Office has allowed its patent application No. 284463, titled "An A3 Adenosine Receptor Ligand for Use for Achieving a Fat Loss Effect." The allowed patent covers the use of A3 adenosine receptor agonists, including the Company's lead drug candidate Namodenoson, for inducing fat loss and treating obesity and related metabolic disorders. This allowance represents a key addition to Can-Fite's expanding global intellectual property portfolio around Namodenoson's anti-obesity activity and follows similar patent advancements in other major jurisdictions including the US, Canada and Australia, strengthening the Company's worldwide protection strategy. Recently the technology granted scientific recognition upon coming up with a breakthrough publication of peer-reviewed study in the International Journal of Obesity, demonstrating the anti-obesity effect of namodenoson
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Analyst Views on CANF
About CANF
Can Fite Biopharma Ltd is an Israel-based clinical-stage biopharmaceutical company engaged in developing orally bioavailable small molecule therapeutic products for the treatment of cancer, liver and inflammatory diseases and erectile dysfunction. The Company co-develop formulations of cannabis components for the treatment of cancer, inflammatory, autoimmune, and metabolic diseases. Its technology utilizes the Gi protein associated A3AR as a therapeutic target. A3AR is expressed in inflammatory and cancer cells, and not significantly expressed in normal cells, suggesting that the receptor could be a target for pharmacological intervention.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Can-Fite Signs Up to $325M Deal with Vetbiolix
- Clinical Trial Progress: Vetbiolix has completed enrollment of 118 dogs in the Phase 2 clinical trial of Piclidenoson, with top-line results expected in Q3 2026, which could significantly boost Can-Fite's revenue in the veterinary market if successful.
- Market Potential: The global canine osteoarthritis market is projected to reach approximately $3 billion by 2028, and Can-Fite's Piclidenoson is poised to become a safe and effective treatment option, addressing the growing demand for pet healthcare.
- Agreement Details: Under the agreement, Can-Fite is entitled to receive up to $325 million in upfront, milestone, and royalty payments, with Vetbiolix responsible for all development and regulatory activities, highlighting the depth and potential of their collaboration.
- Product Background: Piclidenoson is a novel A3 adenosine receptor agonist that has demonstrated excellent safety and efficacy in a Phase III trial for psoriasis, and it is expected to play a significant role in treating canine osteoarthritis in the future.
See More
Can-Fite Biopharma Reports FY 2025 Financial Results
- Declining Financial Performance: Can-Fite Biopharma reported a GAAP EPS of -$5.97 for FY 2025, indicating significant challenges in profitability that could impact investor confidence and future financing capabilities.
- Substantial Revenue Drop: The company generated revenue of $0.41 million, a 38.8% year-over-year decline, reflecting weak market demand for its products, which may lead to tighter funding for future R&D and operations.
- Improved Cash Position: As of December 31, 2025, Can-Fite had cash and cash equivalents and short-term deposits totaling $8.54 million, up from $7.88 million in 2024, demonstrating proactive liquidity management efforts.
- Uncertain Future Outlook: Despite the increase in cash reserves, the ongoing revenue decline and negative earnings situation may limit the company's growth potential, prompting investors to closely monitor subsequent strategic adjustments and market responses.
See More
Can-Fite BioPharma Reports 2025 Financial Results and Clinical Advances
- Clinical Trial Progress: Can-Fite's Phase 2a study in pancreatic cancer achieved its primary safety endpoint, with over 30% of patients alive at the last data cut-off, indicating potential efficacy and positive implications for patient survival.
- Successful Case in HCC: A patient with advanced hepatocellular carcinoma treated with Namodenoson has remained cancer-free for over nine years post-treatment, highlighting the drug's potential as a novel therapeutic option in liver oncology.
- Decline in Financial Performance: Can-Fite reported revenues of $405,000 for 2025, a 40% decrease year-over-year, primarily due to reduced advance payments under distribution agreements, reflecting challenges in revenue generation.
- Increased R&D Expenses: Research and development expenses rose to $6.69 million in 2025, a 16.26% increase, mainly driven by ongoing clinical trials for Namodenoson and Piclidenoson, demonstrating the company's commitment to advancing its drug pipeline.
See More
CAN-FITE ANNOUNCES 2025 FINANCIAL RESULTS AND CLINICAL ADVANCEMENTS, SHOWCASING PROMISING PHASE 2A DATA FOR PANCREATIC CANCER AND NINE-YEAR CANCER-FREE SURVIVAL IN LIVER CANCER PATIENTS
Financial Results: Canfitere reports positive financial results for 2025, indicating strong performance and growth in their operations.
Clinical Progress: The ongoing clinical programs show promising advancements, particularly in Phase 2 trials.
Pancreatic Cancer Focus: The company highlights its commitment to addressing pancreatic cancer, showcasing significant developments in treatment options.
Survival Rates: There is a notable increase in 9-year cancer-free survival rates among liver cancer patients, reflecting the effectiveness of their therapies.
See More
Can-Fite BioPharma's Drug Trial Achieves Success
- Clinical Trial Success: Can-Fite BioPharma's investigational drug Namodenoson successfully met the primary endpoint in a Phase 2a study for advanced pancreatic ductal adenocarcinoma, demonstrating excellent tolerability with no new safety signals, indicating its potential in a difficult-to-treat patient population.
- Survival Rate Tracking: While the primary endpoint has been achieved, secondary endpoints such as overall survival and progression-free survival are still being monitored, with one-third of patients alive at the data cut-off, suggesting the potential for sustained therapeutic effects of Namodenoson.
- Financing Activity: On the same day, Can-Fite announced the immediate exercise of certain outstanding warrants to purchase up to 795,869 ADSs at $9.34 per ADS, generating approximately $4 million in gross proceeds, reflecting the company's proactive financial strategy.
- R&D Investment Plans: The company intends to use the net proceeds to fund ongoing research, clinical trials, and general corporate purposes, further advancing its pipeline of small-molecule drugs targeting cancer, liver, and inflammatory diseases, with Namodenoson positioned as a key candidate in multiple late-stage trials.
See More
Can-Fite BioPharma's Drug Trial Success Boosts Shares
- Clinical Trial Success: Can-Fite BioPharma announced that its drug Namodenoson successfully met the primary endpoint in a Phase 2a study for pretreated pancreatic cancer patients, demonstrating significant survival rate improvements, which analysts view as a promising development for the company's future prospects.
- Good Safety Profile: The drug exhibited good tolerability and safety during trials, with secondary endpoints including overall survival and progression-free survival; at the data cut-off, one-third of patients remained alive, and further survival outcomes are expected to mature and be announced at upcoming scientific meetings.
- Expanded Clinical Trials: Can-Fite is focusing on expanding its clinical trials to further explore Namodenoson's efficacy in advanced liver cancer, indicating the company's ongoing commitment and research potential in cancer treatment, with topline efficacy data expected in Q3 2026.
- Intellectual Property Protection: Can-Fite received a Canadian patent for Namodenoson’s use in reducing fat mass and body weight, enhancing its intellectual property protection as an anti-obesity therapy, which broadens the drug's potential indications and strengthens its market competitiveness.
See More
Can-Fite Signs Up to $325M Deal with Vetbiolix
- Clinical Trial Progress: Vetbiolix has completed enrollment of 118 dogs in the Phase 2 clinical trial of Piclidenoson, with top-line results expected in Q3 2026, which could significantly boost Can-Fite's revenue in the veterinary market if successful.
- Market Potential: The global canine osteoarthritis market is projected to reach approximately $3 billion by 2028, and Can-Fite's Piclidenoson is poised to become a safe and effective treatment option, addressing the growing demand for pet healthcare.
- Agreement Details: Under the agreement, Can-Fite is entitled to receive up to $325 million in upfront, milestone, and royalty payments, with Vetbiolix responsible for all development and regulatory activities, highlighting the depth and potential of their collaboration.
- Product Background: Piclidenoson is a novel A3 adenosine receptor agonist that has demonstrated excellent safety and efficacy in a Phase III trial for psoriasis, and it is expected to play a significant role in treating canine osteoarthritis in the future.
See More
Can-Fite Biopharma Reports FY 2025 Financial Results
- Declining Financial Performance: Can-Fite Biopharma reported a GAAP EPS of -$5.97 for FY 2025, indicating significant challenges in profitability that could impact investor confidence and future financing capabilities.
- Substantial Revenue Drop: The company generated revenue of $0.41 million, a 38.8% year-over-year decline, reflecting weak market demand for its products, which may lead to tighter funding for future R&D and operations.
- Improved Cash Position: As of December 31, 2025, Can-Fite had cash and cash equivalents and short-term deposits totaling $8.54 million, up from $7.88 million in 2024, demonstrating proactive liquidity management efforts.
- Uncertain Future Outlook: Despite the increase in cash reserves, the ongoing revenue decline and negative earnings situation may limit the company's growth potential, prompting investors to closely monitor subsequent strategic adjustments and market responses.
See More
Can-Fite BioPharma Reports 2025 Financial Results and Clinical Advances
- Clinical Trial Progress: Can-Fite's Phase 2a study in pancreatic cancer achieved its primary safety endpoint, with over 30% of patients alive at the last data cut-off, indicating potential efficacy and positive implications for patient survival.
- Successful Case in HCC: A patient with advanced hepatocellular carcinoma treated with Namodenoson has remained cancer-free for over nine years post-treatment, highlighting the drug's potential as a novel therapeutic option in liver oncology.
- Decline in Financial Performance: Can-Fite reported revenues of $405,000 for 2025, a 40% decrease year-over-year, primarily due to reduced advance payments under distribution agreements, reflecting challenges in revenue generation.
- Increased R&D Expenses: Research and development expenses rose to $6.69 million in 2025, a 16.26% increase, mainly driven by ongoing clinical trials for Namodenoson and Piclidenoson, demonstrating the company's commitment to advancing its drug pipeline.
See More
CAN-FITE ANNOUNCES 2025 FINANCIAL RESULTS AND CLINICAL ADVANCEMENTS, SHOWCASING PROMISING PHASE 2A DATA FOR PANCREATIC CANCER AND NINE-YEAR CANCER-FREE SURVIVAL IN LIVER CANCER PATIENTS
Financial Results: Canfitere reports positive financial results for 2025, indicating strong performance and growth in their operations.
Clinical Progress: The ongoing clinical programs show promising advancements, particularly in Phase 2 trials.
Pancreatic Cancer Focus: The company highlights its commitment to addressing pancreatic cancer, showcasing significant developments in treatment options.
Survival Rates: There is a notable increase in 9-year cancer-free survival rates among liver cancer patients, reflecting the effectiveness of their therapies.
See More
Can-Fite BioPharma's Drug Trial Achieves Success
- Clinical Trial Success: Can-Fite BioPharma's investigational drug Namodenoson successfully met the primary endpoint in a Phase 2a study for advanced pancreatic ductal adenocarcinoma, demonstrating excellent tolerability with no new safety signals, indicating its potential in a difficult-to-treat patient population.
- Survival Rate Tracking: While the primary endpoint has been achieved, secondary endpoints such as overall survival and progression-free survival are still being monitored, with one-third of patients alive at the data cut-off, suggesting the potential for sustained therapeutic effects of Namodenoson.
- Financing Activity: On the same day, Can-Fite announced the immediate exercise of certain outstanding warrants to purchase up to 795,869 ADSs at $9.34 per ADS, generating approximately $4 million in gross proceeds, reflecting the company's proactive financial strategy.
- R&D Investment Plans: The company intends to use the net proceeds to fund ongoing research, clinical trials, and general corporate purposes, further advancing its pipeline of small-molecule drugs targeting cancer, liver, and inflammatory diseases, with Namodenoson positioned as a key candidate in multiple late-stage trials.
See More
Can-Fite BioPharma's Drug Trial Success Boosts Shares
- Clinical Trial Success: Can-Fite BioPharma announced that its drug Namodenoson successfully met the primary endpoint in a Phase 2a study for pretreated pancreatic cancer patients, demonstrating significant survival rate improvements, which analysts view as a promising development for the company's future prospects.
- Good Safety Profile: The drug exhibited good tolerability and safety during trials, with secondary endpoints including overall survival and progression-free survival; at the data cut-off, one-third of patients remained alive, and further survival outcomes are expected to mature and be announced at upcoming scientific meetings.
- Expanded Clinical Trials: Can-Fite is focusing on expanding its clinical trials to further explore Namodenoson's efficacy in advanced liver cancer, indicating the company's ongoing commitment and research potential in cancer treatment, with topline efficacy data expected in Q3 2026.
- Intellectual Property Protection: Can-Fite received a Canadian patent for Namodenoson’s use in reducing fat mass and body weight, enhancing its intellectual property protection as an anti-obesity therapy, which broadens the drug's potential indications and strengthens its market competitiveness.
See More
