AstraZeneca Reports Positive Interim Results from I CAN Phase III Trial
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 3 days ago
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Should l Buy AZN?
AstraZeneca announces "positive high-level results" from a prespecified interim analysis of the I CAN Phase III trial showed that Ultomiris met its primary endpoint, demonstrating a statistically significant reduction of proteinuria, based on 24-hour urine protein creatinine ratio, at week 34 in adults with immunoglobulin A nephropathy who are at risk of disease progression. The primary endpoint of change from baseline in estimated glomerular filtration rate will be measured at week 106. Jonathan Barratt, MD, Mayer Professor of Renal Medicine, University of Leicester, United Kingdom, and I CAN trial investigator, said: "Many people living with IgAN continue to progress to kidney failure, ultimately requiring dialysis or a transplant - outcomes that can place profound burden on patients' daily lives - despite advances in care. The interim I CAN results demonstrate that blocking terminal complement activation, a central driver of kidney inflammation in IgAN, with Ultomiris may play a promising role in reducing proteinuria. We look forward to understanding the full clinical impact of Ultomiris in treating this disease following study completion at two years."
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Analyst Views on AZN
Wall Street analysts forecast AZN stock price to rise
14 Analyst Rating
13 Buy
0 Hold
1 Sell
Strong Buy
Current: 192.300
Low
157.61
Averages
213.64
High
252.18
Current: 192.300
Low
157.61
Averages
213.64
High
252.18
About AZN
AstraZeneca PLC is a United Kingdom-based science-led biopharmaceutical company. The Company focuses on the discovery, development, and commercialization of prescription medicines. The Company operates across therapy areas, including Oncology; Cardiovascular, Renal and Metabolism (CVRM); Respiratory and Immunology (R&I); Vaccines and Immune Therapies (V&I), and Rare Disease. In the Oncology area, its key products include Tagrisso, Imfinzi, Calquence, Lynparza, and Enhertu. The key products of CVRM area include Farxiga/Forxiga, Brilinta/Brilique, Crestor, and Lokelma. In the R&I area, the key products are Symbicort, Fasenra, Breztri/Trixeo, and Tezspire. In the V&I Therapies area, the products are Beyfortus and FluMist. The products in the Rare Disease area are Ultomiris, Soliris, Strensiq, and Koselugo. It has about 191 projects in its development pipeline, including 19 new molecular entities (NMEs) in the late-stage pipeline. The Company distributes its products in over 125 countries.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Study Design: The 52-week study evaluated tozorakimab 300 mg administered biweekly against a placebo, aiming to assess its additional efficacy on top of standard inhaled therapy, further validating its clinical application value.
- Favorable Safety Profile: AstraZeneca noted that tozorakimab was generally well tolerated with a safety profile consistent with prior trials, and plans to submit the results to global regulators and present them at future medical events, facilitating its market introduction.
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- Safety Profile: Tozorakimab was generally well tolerated with a favorable safety profile consistent with previous trials, providing strong support for its future regulatory approval and the potential to offer new treatment options for COPD patients.
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