Astellas Announces Encouraging Phase 3 Results for PADCEV Combination Therapy in Muscle-Invasive Bladder Cancer
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 18 2025
0mins
Should l Buy PFE?
Source: NASDAQ.COM
Positive Clinical Trial Results: Astellas Pharma and Pfizer reported successful topline results from the Phase 3 EV-304 trial, showing that the combination of PADCEV and Keytruda significantly improves event-free survival and overall survival in muscle-invasive bladder cancer patients compared to standard chemotherapy.
First Platinum-Free Regimen: The combination of PADCEV and Keytruda is the first platinum-free treatment to demonstrate improvements in both event-free and overall survival for cisplatin-eligible patients undergoing surgery for bladder cancer.
Improved Pathologic Response Rates: The trial also showed a significant increase in pathologic complete response rates for patients treated with PADCEV plus Keytruda compared to those receiving standard neoadjuvant chemotherapy.
Future Regulatory Steps: Findings from the EV-304 trial will be presented at a medical meeting and discussed with global health authorities to support potential regulatory filings for this new treatment approach.
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Analyst Views on PFE
Wall Street analysts forecast PFE stock price to rise
16 Analyst Rating
5 Buy
11 Hold
0 Sell
Moderate Buy
Current: 27.370
Low
24.00
Averages
28.56
High
35.00
Current: 27.370
Low
24.00
Averages
28.56
High
35.00
About PFE
Pfizer Inc. is a research-based, global biopharmaceutical company. The Company is engaged in the discovery, development, manufacture, marketing, sale and distribution of biopharmaceutical products worldwide. Its Biopharma segment includes the Pfizer U.S. Commercial Division, and the Pfizer International Commercial Division. Its product categories include oncology, primary care and specialty care. Its oncology products include Ibrance, Xtandi, Padcev, Adcetris, Inlyta, Lorbrena, Bosulif, Tukysa, Braftovi, Mektovi, Orgovyx, Elrexfio, Tivdak and Talzenna. Its primary care products include Eliquis, Nurtec ODT/Vydura, Zavzpret, the Prevnar family, Comirnaty, Abrysvo, FSME/IMMUN-TicoVac, Nimenrix, Trumenba, and Paxlovid. Its specialty care products include Xeljanz, Enbrel (outside the United States and Canada), Inflectra, Abrilada, Cibinqo, Litfulo, Eucrisa, Velsipity, the Vyndaqel family, Genotropin, BeneFIX, Xyntha, Somavert, Ngenla, Hympavzi, Sulperazon, Zavicefta, Octagam and others.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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