Ascendis Pharma Reports Positive Phase 2 Results for Pediatric Achondroplasia Treatment
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 09 2026
0mins
Source: NASDAQ.COM
- Clinical Trial Results: Ascendis Pharma's COACH Phase 2 trial for pediatric achondroplasia demonstrated significant annualized growth velocity increases, with treatment-naïve patients achieving 8.8 cm per year, a 3.9 cm gain from baseline, indicating the therapy's effectiveness in enhancing growth outcomes.
- Safety Profile: The combination therapy was well tolerated over the 52-week treatment period, with all patients completing the trial and no serious adverse events reported, such as symptomatic hypotension or fractures, underscoring the therapy's safety and feasibility.
- Future Research Directions: Ascendis is preparing for a pivotal Phase 3 trial to compare TransCon CNP monotherapy with the combination regimen, while also planning to integrate the combination therapy into its existing U.S. regulatory filing strategy, aiming to simplify treatment for patients and caregivers.
- Financial Position: As of the end of Q3, Ascendis reported approximately €539 million in cash and cash equivalents, ensuring funding for future clinical trials and technology expansion, further supporting its development in endocrine and rare disease indications.
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Analyst Views on ASND
Wall Street analysts forecast ASND stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ASND is 267.50 USD with a low forecast of 240.00 USD and a high forecast of 325.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
13 Analyst Rating
13 Buy
0 Hold
0 Sell
Strong Buy
Current: 223.950
Low
240.00
Averages
267.50
High
325.00
Current: 223.950
Low
240.00
Averages
267.50
High
325.00
About ASND
Ascendis Pharma A/S is a Denmark-based company that manufactures pharmaceutical products. The Company produces products for the treatments of growth hormone deficiency, endocrinology, central nervous system disorders, infectious diseases, and diabetes. The Company operates globally though its subsidiaries: Ascendis Pharma GmbH (Germany), Ascendis Pharma, Inc. (Delaware, United States), Ascendis Pharma Endocrinology, Inc. (Delaware, United States), Ascendis Pharma, Ophthalmology Division A/S (Denmark), Ascendis Pharma, Endocrinology Division A/S (Denmark), Ascendis Pharma Bone Diseases A/S (Denmark), Ascendis Pharma Growth Disorders A/S (Denmark) and Ascendis Pharma Oncology Division A/S (Denmark).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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