Arrowhead Pharmaceuticals faces stock decline amid market weakness
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 29 2026
0mins
Should l Buy ARWR?
Source: NASDAQ.COM
Arrowhead Pharmaceuticals Inc. experienced a significant price drop of 9.46%, crossing below its 5-day SMA, reflecting a challenging trading environment.
This decline occurs amid broader market weakness, with the Nasdaq-100 down 0.37% and the S&P 500 down 0.46%. Despite RBC Capital reaffirming an 'Outperform' rating for Arrowhead Pharmaceuticals, the projected average price target indicates a potential downside, contributing to investor caution.
The company's recent initiatives, including the grant of restricted stock units to new employees, aim to enhance operational efficiency and attract talent. However, the overall market sentiment and projected revenue decrease may overshadow these efforts, leading to a cautious outlook for the stock.
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Analyst Views on ARWR
Wall Street analysts forecast ARWR stock price to rise
11 Analyst Rating
8 Buy
3 Hold
0 Sell
Moderate Buy
Current: 63.690
Low
35.00
Averages
82.00
High
110.00
Current: 63.690
Low
35.00
Averages
82.00
High
110.00
About ARWR
Arrowhead Pharmaceuticals, Inc. develops medicines that treat intractable diseases by silencing the genes that cause them. The Company's therapies, using a broad portfolio of ribonucleic acid (RNA) chemistries and modes of delivery, trigger the RNA interference (RNAi) mechanism to induce rapid, deep and durable knockdown of target genes. The Company's Targeted RNAi Molecule (TRiMTM) platform utilizes ligand-mediated delivery and is designed to enable tissue-specific targeting while being structurally simple. It is focused on various therapeutic areas, such as cardiometabolic, pulmonary, liver, muscle and central nervous system. It has around 16 clinical-stage investigational medicines (wholly owned and partnered), which range in development stage from Phase I to Phase III. The Company's pipeline products include Plozasiran, Zodasiran, Olpasiran, ARO-RAGE, ARO-MMP7, GSK-4532990, Fazirsiran, GSK5637608, ARO-CFB, ARO-INHBE, ARO-C3, ARO-PNPLA3, ARO-DUX4, ARO-DM1 and ARO-ATXN2.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Morgan Stanley Lowers Arrowhead Price Target to $78
- Sales Forecast Downgrade: Morgan Stanley has lowered Arrowhead Pharmaceuticals (ARWR)'s price target from $81 to $78, indicating that despite optimistic early launch trends, significant sales from familial chylomicronemia syndrome are expected to be limited in 2026, potentially impacting future revenues.
- Clinical Trial Progress: On January 27, Arrowhead announced the dosing of the first participants in its ARO-DIMER-PA clinical trial, aimed at treating atherosclerotic cardiovascular disease caused by mixed hyperlipidemia, showcasing the company's R&D potential in the cardiovascular space.
- Dual-Target Treatment Strategy: ARO-DIMER-PA aims to effectively lower lipid levels by simultaneously suppressing the APOC3 and PCSK9 genes, offering a novel approach for patients with elevated cholesterol and triglycerides, thereby enhancing Arrowhead's competitiveness in the biotech sector.
- RNA Interference Platform Advantage: Arrowhead's proprietary TRiM RNAi platform enables the development of targeted, durable therapies for previously “undruggable” conditions, advancing treatments across cardiometabolic, rare genetic, and other diseases, highlighting its significant role in biopharmaceutical innovation.
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- IP Expansion: Oncotelic Therapeutics announced enhancements to its OT-101 platform's international intellectual property protection in neurology and oncology, which will bolster its competitive edge in treating complex biological mechanisms.
- Strengthened Clinical Foundation: OT-101 has demonstrated strong performance in multiple oncology trials, recently securing a patent for Parkinson's disease in Australia, laying a solid foundation for future commercialization efforts.
- Cross-Indication Opportunities: Oncotelic's R&D strategy focuses on the TGF-β signaling pathway, which is significant in both oncology and neurological diseases, indicating potential value and strategic flexibility across multiple markets.
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Strategic Shift in Biopharma Dealmaking
- Strategic Transformation: Pharmaceutical companies are increasingly prioritizing late-stage assets with clinical validation over early-stage projects, positioning Oncotelic Therapeutics as a focal point due to its multiple clinical-stage programs in oncology and CNS, aligning with current M&A priorities.
- IP Expansion: Oncotelic Therapeutics announced enhancements to its global intellectual property protection for the OT-101 platform, particularly in drug delivery for neurology and oncology, which will bolster its competitive edge and strategic value in the market.
- Market Demand: The rising need for treatments for CNS disorders such as Alzheimer's and Parkinson's highlights the potential of Oncotelic's OT-101 platform, which targets the TGF-β signaling pathway to address these significant unmet medical needs.
- Capital Efficiency: The biotech industry is increasingly emphasizing capital efficiency, and Oncotelic's strategy of repositioning clinically validated mechanisms into additional therapeutic indications reduces risk while maximizing the value of prior investments, enhancing its market appeal.
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- Revenue Growth: Casgevy gene-editing therapy generated $54 million in Q4 2025 and $116 million for the full year, indicating strong market demand and significant business growth potential.
- Increased Patient Treatments: A total of 147 patients initiated treatment in 2025, nearly tripling from 2024, with 30 infusions occurring in Q4, reflecting heightened acceptance and confidence in the therapy.
- Pipeline Advancement: The company continues to advance its in vivo liver editing programs, with CTX310 in Phase 1b trials for lipid disorders and CTX321 progressing through enabling studies, with updates expected in the second half of 2026.
- Financial Position: CRISPR Therapeutics ended 2025 with $1.98 billion in cash and marketable securities, despite R&D expenses rising to $83.5 million in Q4 and net loss widening to $130.6 million, market confidence in its future growth remains strong.
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Arrowhead Pharmaceuticals Q1 2026 Earnings Call Highlights
- FDA Approval of New Drug: Arrowhead received FDA approval and launched REDEMPLO in the U.S. for familial chylomicronemia syndrome, marking the company's first regulatory approval and initiating a new phase as a commercial entity, which is expected to drive revenue growth.
- Strong Financial Performance: For Q4 2025, net income was $30.8 million with earnings per share of $0.22, and total revenue reached $264 million, primarily driven by licensing and collaboration agreements with Sarepta and Novartis, showcasing the company's strong execution in the market.
- Successful Capital Raising: The company completed $1.33 billion in capital raising during the reporting period, including a $200 million upfront payment from Novartis and a $200 million milestone payment from Sarepta, providing robust funding support for future R&D and commercialization efforts.
- Optimistic Future Outlook: Management anticipates achieving positive cash flow through multiple independent and partnered product launches, emphasizing the commercial sales progress of REDEMPLO and upcoming key clinical data releases, indicating significant growth potential for the company in the coming years.
See More
Arrowhead Pharmaceuticals Q1 Earnings Exceed Expectations
- Earnings Beat: Arrowhead Pharmaceuticals reported a Q1 GAAP EPS of $0.22, surpassing expectations by $0.37, indicating strong profitability that boosts investor confidence.
- Significant Revenue Growth: The company achieved Q1 revenue of $264.03 million, exceeding market expectations of $230.85 million, reflecting sustained demand for its products and further solidifying its market position.
- Stock Performance Volatility: Despite the earnings beat, Arrowhead's shares fell by 2%, indicating market caution regarding future growth, which may impact short-term investor sentiment.
- Expanded Financing Plans: Arrowhead upsized its convertible notes offering to $625 million and priced its stock offering at $64.50 per share, demonstrating a proactive approach to future expansion and R&D investments.
See More
Morgan Stanley Lowers Arrowhead Price Target to $78
- Sales Forecast Downgrade: Morgan Stanley has lowered Arrowhead Pharmaceuticals (ARWR)'s price target from $81 to $78, indicating that despite optimistic early launch trends, significant sales from familial chylomicronemia syndrome are expected to be limited in 2026, potentially impacting future revenues.
- Clinical Trial Progress: On January 27, Arrowhead announced the dosing of the first participants in its ARO-DIMER-PA clinical trial, aimed at treating atherosclerotic cardiovascular disease caused by mixed hyperlipidemia, showcasing the company's R&D potential in the cardiovascular space.
- Dual-Target Treatment Strategy: ARO-DIMER-PA aims to effectively lower lipid levels by simultaneously suppressing the APOC3 and PCSK9 genes, offering a novel approach for patients with elevated cholesterol and triglycerides, thereby enhancing Arrowhead's competitiveness in the biotech sector.
- RNA Interference Platform Advantage: Arrowhead's proprietary TRiM RNAi platform enables the development of targeted, durable therapies for previously “undruggable” conditions, advancing treatments across cardiometabolic, rare genetic, and other diseases, highlighting its significant role in biopharmaceutical innovation.
See More
Strategic Shift in Biotech Dealmaking
- Biotech Deal Trends: Pharmaceutical companies are increasingly prioritizing late-stage assets with clinical validation over early-stage projects, positioning firms like Oncotelic Therapeutics as strategic assets capable of accelerating commercialization pathways.
- IP Expansion: Oncotelic Therapeutics announced enhancements to its OT-101 platform's international intellectual property protection in neurology and oncology, which will bolster its competitive edge in treating complex biological mechanisms.
- Strengthened Clinical Foundation: OT-101 has demonstrated strong performance in multiple oncology trials, recently securing a patent for Parkinson's disease in Australia, laying a solid foundation for future commercialization efforts.
- Cross-Indication Opportunities: Oncotelic's R&D strategy focuses on the TGF-β signaling pathway, which is significant in both oncology and neurological diseases, indicating potential value and strategic flexibility across multiple markets.
See More
Strategic Shift in Biopharma Dealmaking
- Strategic Transformation: Pharmaceutical companies are increasingly prioritizing late-stage assets with clinical validation over early-stage projects, positioning Oncotelic Therapeutics as a focal point due to its multiple clinical-stage programs in oncology and CNS, aligning with current M&A priorities.
- IP Expansion: Oncotelic Therapeutics announced enhancements to its global intellectual property protection for the OT-101 platform, particularly in drug delivery for neurology and oncology, which will bolster its competitive edge and strategic value in the market.
- Market Demand: The rising need for treatments for CNS disorders such as Alzheimer's and Parkinson's highlights the potential of Oncotelic's OT-101 platform, which targets the TGF-β signaling pathway to address these significant unmet medical needs.
- Capital Efficiency: The biotech industry is increasingly emphasizing capital efficiency, and Oncotelic's strategy of repositioning clinically validated mechanisms into additional therapeutic indications reduces risk while maximizing the value of prior investments, enhancing its market appeal.
See More
Casgevy Therapy Revenue Shows Significant Growth
- Revenue Growth: Casgevy gene-editing therapy generated $54 million in Q4 2025 and $116 million for the full year, indicating strong market demand and significant business growth potential.
- Increased Patient Treatments: A total of 147 patients initiated treatment in 2025, nearly tripling from 2024, with 30 infusions occurring in Q4, reflecting heightened acceptance and confidence in the therapy.
- Pipeline Advancement: The company continues to advance its in vivo liver editing programs, with CTX310 in Phase 1b trials for lipid disorders and CTX321 progressing through enabling studies, with updates expected in the second half of 2026.
- Financial Position: CRISPR Therapeutics ended 2025 with $1.98 billion in cash and marketable securities, despite R&D expenses rising to $83.5 million in Q4 and net loss widening to $130.6 million, market confidence in its future growth remains strong.
See More
Arrowhead Pharmaceuticals Q1 2026 Earnings Call Highlights
- FDA Approval of New Drug: Arrowhead received FDA approval and launched REDEMPLO in the U.S. for familial chylomicronemia syndrome, marking the company's first regulatory approval and initiating a new phase as a commercial entity, which is expected to drive revenue growth.
- Strong Financial Performance: For Q4 2025, net income was $30.8 million with earnings per share of $0.22, and total revenue reached $264 million, primarily driven by licensing and collaboration agreements with Sarepta and Novartis, showcasing the company's strong execution in the market.
- Successful Capital Raising: The company completed $1.33 billion in capital raising during the reporting period, including a $200 million upfront payment from Novartis and a $200 million milestone payment from Sarepta, providing robust funding support for future R&D and commercialization efforts.
- Optimistic Future Outlook: Management anticipates achieving positive cash flow through multiple independent and partnered product launches, emphasizing the commercial sales progress of REDEMPLO and upcoming key clinical data releases, indicating significant growth potential for the company in the coming years.
See More
Arrowhead Pharmaceuticals Q1 Earnings Exceed Expectations
- Earnings Beat: Arrowhead Pharmaceuticals reported a Q1 GAAP EPS of $0.22, surpassing expectations by $0.37, indicating strong profitability that boosts investor confidence.
- Significant Revenue Growth: The company achieved Q1 revenue of $264.03 million, exceeding market expectations of $230.85 million, reflecting sustained demand for its products and further solidifying its market position.
- Stock Performance Volatility: Despite the earnings beat, Arrowhead's shares fell by 2%, indicating market caution regarding future growth, which may impact short-term investor sentiment.
- Expanded Financing Plans: Arrowhead upsized its convertible notes offering to $625 million and priced its stock offering at $64.50 per share, demonstrating a proactive approach to future expansion and R&D investments.
See More
