Wedbush Affirms Outperform Rating for AnaptysBio, Keeps $50 Price Target Intact
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 24 2025
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Should l Buy ANAB?
Source: Benzinga
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Analyst Views on ANAB
Wall Street analysts forecast ANAB stock price to rise
10 Analyst Rating
9 Buy
1 Hold
0 Sell
Strong Buy
Current: 54.900
Low
50.00
Averages
74.13
High
140.00
Current: 54.900
Low
50.00
Averages
74.13
High
140.00
About ANAB
AnaptysBio, Inc. is a clinical-stage biotechnology company. The Company is focused on delivering immunology therapeutics for autoimmune and inflammatory diseases. The Company’s lead program, Rosnilimab, is a depleter and agonist targeting PD-1+ T cells, is in a Phase IIb trial for the treatment of rheumatoid arthritis and in a Phase II trial for the treatment of ulcerative colitis. The Company’s pipeline also includes ANB033, a CD122 antagonist, and ANB101, a blood dendritic cell antigen 2 (BDCA2) modulator, in Phase I trials. It has also discovered multiple therapeutic antibodies licensed to GSK in a financial collaboration for immuno-oncology, including a PD-1 antagonist (Jemperli (dostarlimab-gxly)) and a TIM-3 antagonist (cobolimab, GSK4069889). Rosnilimab is an IgG1 antibody that directly targets PD-1+ T cells, resulting in their depletion or agonism, impacting pathogenic drivers of autoimmune and inflammatory diseases.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Anaptysbio Biotech Stock Breaks Trendline
- Trendline Break: Anaptysbio's stock cleared a trendline entry near 50 on Monday, indicating strong market momentum that may attract increased investor interest.
- Buy Point Confirmation: The stock is currently in a base with a buy point set at 52.47, and a breakout above this level could trigger a larger buying wave, further driving the stock price upward.
- Positive Market Reaction: Increased investor attention on Anaptysbio may lead to a rise in trading volume in the short term, enhancing liquidity and stabilizing the stock price.
- Technical Analysis: The combination of breaking the trendline and confirming the buy point suggests a bullish sentiment in the market, potentially laying the groundwork for the company's future R&D progress and financial performance.
See More
AnaptysBio Director Sells 3,900 Shares for $193,342.50
- Share Sale: On December 23, AnaptysBio Director J. Anthony Ware sold 3,900 shares at $49.58 each for a total of $193,342.50, reducing his direct holdings by 28.82% from 13,530 to 9,630 shares.
- Ownership Structure: All shares sold were directly held, with no involvement from indirect entities or derivative instruments, indicating Ware's continued economic alignment with the company as he retains 9,630 shares along with options for 126,085 shares and 6,030 restricted stock units.
- Market Performance: Over the past year, AnaptysBio's stock surged more than 260%, significantly outperforming the S&P 500's approximately 17% gain, reflecting strong performance and market confidence in the biotechnology sector.
- Financial Health: As of the end of Q3, AnaptysBio reported $256.7 million in cash and investments, with collaboration revenue rising to $76.3 million from $30 million a year earlier, showcasing the company's innovative capabilities in areas of high unmet medical need.
See More
AnaptysBio Director Sells 3,900 Shares for $193,342.50
- Ownership Reduction: AnaptysBio Director J. Anthony Ware executed an open-market sale of 3,900 shares for $193,342.50, reducing his direct holdings by 28.82%, indicating a significant adjustment in his personal investment portfolio within a single event.
- First Open-Market Sale: This transaction marks Ware's first open-market sale at AnaptysBio, with the previous five filings being administrative in nature, highlighting a notable shift in his holding strategy within the company.
- Market Performance Context: The sale occurred at a stock price of $50.04, following a remarkable 264.63% one-year return, suggesting that Ware chose to realize gains during a period of elevated valuation, reflecting his acknowledgment of the current market conditions.
- Economic Alignment Maintained: Despite the reduction in direct holdings, Ware retains 9,630 shares and has options for an additional 126,085 shares along with 6,030 restricted stock units, ensuring that his economic alignment with the company remains intact.
See More
AnaptysBio CMO Paul Lizzul Sells 3,650 Shares for $163,191.50
- Share Transaction: AnaptysBio's Chief Medical Officer Paul Lizzul sold 3,650 shares on Thursday for approximately $163,191.50, reducing his direct stake by 8% from 45,738 to 42,088 shares, indicating a strategic liquidity management approach.
- Transaction Context: The sale was solely to cover tax withholding obligations related to RSU vesting, suggesting Lizzul's lack of intent for broader selling, which reflects confidence in the company's long-term value.
- Financial Position: AnaptysBio ended Q3 with $256.7 million in cash and equivalents, with expectations to reach $300 million by the end of 2025, highlighting the company's potential for capital flexibility and sustained growth.
- Buyback Authorization: The board expanded its stock repurchase authorization to $100 million, reinforcing confidence in the durability of future revenue streams and capital flexibility, indicating a commitment to creating long-term shareholder value.
See More
AnaptysBio CMO Sells 3,650 Shares for $163,191.50
- Share Sale: AnaptysBio's CMO Paul F. Lizzul sold 3,650 shares for approximately $163,191.50, indicating a routine administrative transaction to cover tax obligations associated with RSU vesting.
- Option Exercise: The transaction involved exercising 8,525 options, with 3,650 shares sold immediately while the remainder increased Lizzul's direct share count, reflecting stability in the company's insider ownership structure.
- Market Performance: AnaptysBio's stock closed at $44.71 on the trade date, with a market capitalization of $1.24 billion and a 214.36% increase in share price over the past year, showcasing strong market confidence in its immunology pipeline.
- Financial Position: The company reported $256.7 million in cash and equivalents as of Q3, with expectations to reach $300 million by the end of 2025, demonstrating robust capital flexibility and ongoing growth potential.
See More
AnaptysBio Fights Tesaro Lawsuit, Seeks to Uphold Licensing Rights
- Legal Dispute Escalation: AnaptysBio has filed a counterclaim against Tesaro, seeking judicial confirmation that Tesaro breached its licensing agreement for the cancer drug Jemperli, demonstrating the company's firm stance in protecting its rights.
- Royalty Revenue Potential: Under the 2014 agreement, AnaptysBio is entitled to tiered royalties ranging from 8% to 25% of net sales of Jemperli, with obligations extending through U.S. patent expiration in 2035 and EU protection through 2036, ensuring a long-term revenue stream.
- Strong Stock Performance: AnaptysBio's stock rose 4.02% to $45.56 during the litigation, reflecting market confidence in the company's legal position and optimism regarding future revenue potential.
- Clinical Trial Halt: Despite facing legal challenges, AnaptysBio discontinued its Phase 2 trial of rosnilimab for moderate-to-severe ulcerative colitis in November 2025, as it failed to meet primary endpoints, indicating challenges and adjustments in the company's R&D efforts.
See More
Anaptysbio Biotech Stock Breaks Trendline
- Trendline Break: Anaptysbio's stock cleared a trendline entry near 50 on Monday, indicating strong market momentum that may attract increased investor interest.
- Buy Point Confirmation: The stock is currently in a base with a buy point set at 52.47, and a breakout above this level could trigger a larger buying wave, further driving the stock price upward.
- Positive Market Reaction: Increased investor attention on Anaptysbio may lead to a rise in trading volume in the short term, enhancing liquidity and stabilizing the stock price.
- Technical Analysis: The combination of breaking the trendline and confirming the buy point suggests a bullish sentiment in the market, potentially laying the groundwork for the company's future R&D progress and financial performance.
See More
AnaptysBio Director Sells 3,900 Shares for $193,342.50
- Share Sale: On December 23, AnaptysBio Director J. Anthony Ware sold 3,900 shares at $49.58 each for a total of $193,342.50, reducing his direct holdings by 28.82% from 13,530 to 9,630 shares.
- Ownership Structure: All shares sold were directly held, with no involvement from indirect entities or derivative instruments, indicating Ware's continued economic alignment with the company as he retains 9,630 shares along with options for 126,085 shares and 6,030 restricted stock units.
- Market Performance: Over the past year, AnaptysBio's stock surged more than 260%, significantly outperforming the S&P 500's approximately 17% gain, reflecting strong performance and market confidence in the biotechnology sector.
- Financial Health: As of the end of Q3, AnaptysBio reported $256.7 million in cash and investments, with collaboration revenue rising to $76.3 million from $30 million a year earlier, showcasing the company's innovative capabilities in areas of high unmet medical need.
See More
AnaptysBio Director Sells 3,900 Shares for $193,342.50
- Ownership Reduction: AnaptysBio Director J. Anthony Ware executed an open-market sale of 3,900 shares for $193,342.50, reducing his direct holdings by 28.82%, indicating a significant adjustment in his personal investment portfolio within a single event.
- First Open-Market Sale: This transaction marks Ware's first open-market sale at AnaptysBio, with the previous five filings being administrative in nature, highlighting a notable shift in his holding strategy within the company.
- Market Performance Context: The sale occurred at a stock price of $50.04, following a remarkable 264.63% one-year return, suggesting that Ware chose to realize gains during a period of elevated valuation, reflecting his acknowledgment of the current market conditions.
- Economic Alignment Maintained: Despite the reduction in direct holdings, Ware retains 9,630 shares and has options for an additional 126,085 shares along with 6,030 restricted stock units, ensuring that his economic alignment with the company remains intact.
See More
AnaptysBio CMO Paul Lizzul Sells 3,650 Shares for $163,191.50
- Share Transaction: AnaptysBio's Chief Medical Officer Paul Lizzul sold 3,650 shares on Thursday for approximately $163,191.50, reducing his direct stake by 8% from 45,738 to 42,088 shares, indicating a strategic liquidity management approach.
- Transaction Context: The sale was solely to cover tax withholding obligations related to RSU vesting, suggesting Lizzul's lack of intent for broader selling, which reflects confidence in the company's long-term value.
- Financial Position: AnaptysBio ended Q3 with $256.7 million in cash and equivalents, with expectations to reach $300 million by the end of 2025, highlighting the company's potential for capital flexibility and sustained growth.
- Buyback Authorization: The board expanded its stock repurchase authorization to $100 million, reinforcing confidence in the durability of future revenue streams and capital flexibility, indicating a commitment to creating long-term shareholder value.
See More
AnaptysBio CMO Sells 3,650 Shares for $163,191.50
- Share Sale: AnaptysBio's CMO Paul F. Lizzul sold 3,650 shares for approximately $163,191.50, indicating a routine administrative transaction to cover tax obligations associated with RSU vesting.
- Option Exercise: The transaction involved exercising 8,525 options, with 3,650 shares sold immediately while the remainder increased Lizzul's direct share count, reflecting stability in the company's insider ownership structure.
- Market Performance: AnaptysBio's stock closed at $44.71 on the trade date, with a market capitalization of $1.24 billion and a 214.36% increase in share price over the past year, showcasing strong market confidence in its immunology pipeline.
- Financial Position: The company reported $256.7 million in cash and equivalents as of Q3, with expectations to reach $300 million by the end of 2025, demonstrating robust capital flexibility and ongoing growth potential.
See More
AnaptysBio Fights Tesaro Lawsuit, Seeks to Uphold Licensing Rights
- Legal Dispute Escalation: AnaptysBio has filed a counterclaim against Tesaro, seeking judicial confirmation that Tesaro breached its licensing agreement for the cancer drug Jemperli, demonstrating the company's firm stance in protecting its rights.
- Royalty Revenue Potential: Under the 2014 agreement, AnaptysBio is entitled to tiered royalties ranging from 8% to 25% of net sales of Jemperli, with obligations extending through U.S. patent expiration in 2035 and EU protection through 2036, ensuring a long-term revenue stream.
- Strong Stock Performance: AnaptysBio's stock rose 4.02% to $45.56 during the litigation, reflecting market confidence in the company's legal position and optimism regarding future revenue potential.
- Clinical Trial Halt: Despite facing legal challenges, AnaptysBio discontinued its Phase 2 trial of rosnilimab for moderate-to-severe ulcerative colitis in November 2025, as it failed to meet primary endpoints, indicating challenges and adjustments in the company's R&D efforts.
See More
