Moleculin Biotech Executes 1-for-25 Reverse Stock Split, Reducing Shares to 2.1 Million
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 26 2025
0mins
Should l Buy MBRX?
Source: Globenewswire
- Reverse Stock Split Implementation: Moleculin Biotech announced a 1-for-25 reverse stock split effective December 1, 2025, reducing outstanding shares from approximately 51.7 million to about 2.1 million, aimed at increasing share price to attract investor interest.
- Exchange Transition: Following the reverse split, the company's common stock will trade on the Nasdaq Capital Market under the existing ticker symbol 'MBRX' but with a new CUSIP number 60855D 408, which will help maintain consistency in the capital market.
- Shareholder Impact: The reverse split will not result in fractional shares, with shareholders receiving cash compensation instead, a measure designed to prevent dilution of shareholder equity and protect shareholder interests.
- Financing Challenges: Moleculin requires significant additional financing to support its clinical trials, and while the reverse split may help boost share price, the company currently has no commitments for such financing, leaving its future development uncertain.
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Analyst Views on MBRX
Wall Street analysts forecast MBRX stock price to rise
3 Analyst Rating
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 4.216
Low
20.00
Averages
24.33
High
31.00
Current: 4.216
Low
20.00
Averages
24.33
High
31.00
About MBRX
Moleculin Biotech, Inc. is a Phase III clinical-stage pharmaceutical company advancing a pipeline of therapeutic candidates addressing tumors and viruses. The Company is conducting a pivotal Phase III trial evaluating Annamycin, a non-cardiotoxic anthracycline, in combination with Cytarabine for the treatment of subjects with relapsed/refractory acute myeloid leukemia (AML). It has three core technologies and six drug candidates, three of which have shown human activity in clinical trials. Its core technologies consist of Annamycin, WP1066 Portfolio, and WP1122 Portfolio. Annamycin is designed to avoid multidrug resistance mechanisms and cardiotoxicity. Its WP1066, is an Immune/Transcription Modulator capable of inhibiting p-STAT3 and other transcription factors, and its portfolio includes WP1193, and WP1220. Its WP1122 contains compounds including WP1096, and WP1097, which is designed to exploit the potential uses of inhibitors of glycolysis such as 2-deoxy-D-glucose (2-DG).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Moleculin Launches CEO Corner Platform for Investor Insights
- CEO Corner Launch: Moleculin Biotech announced the launch of its CEO Corner on February 13, 2026, designed to provide deeper insights into corporate developments and clinical progress from CEO Walter Klemp, thereby enhancing trust among investors and stakeholders.
- Clinical Trial Progress: The company is conducting the MIRACLE clinical trial to evaluate Annamycin in combination with cytarabine for treating relapsed acute myeloid leukemia (AML), paving the way for potential drug approval and demonstrating the company's commitment to advancing its pipeline.
- Drug Development Strategy: Annamycin, a next-generation oncology drug, aims to avoid multidrug resistance and reduce cardiotoxicity, expected to provide effective solutions for AML and soft tissue sarcoma, thereby enhancing the company's competitive position in cancer treatment.
- Enhanced Investor Engagement: The CEO Corner platform allows investors to submit questions and topics, facilitating direct communication with the company, reflecting Moleculin's emphasis on transparency and timely communication to enhance long-term shareholder value.
See More
Moleculin Biotech's 2026 MIRACLE Trial Data Unblinding Expected
- Clinical Trial Progress: Moleculin expects to complete the unblinding of data for 45 subjects in the MIRACLE trial in Q1 2026, which is anticipated to provide critical efficacy data for treating acute myeloid leukemia (AML), thereby enhancing Annamycin's market recognition.
- New Indication Expansion: Annamycin is set to initiate a clinical trial for pancreatic cancer in 2026, funded by Atlantic Health, based on preclinical data showing unexpected activity in pancreatic cancer models, further enhancing its market potential.
- Global Trial Network: The MIRACLE trial has expanded to nine countries, including the US and several European nations, with 46 trial sites selected, and is expected to recruit the 90th subject by Q1 2026, demonstrating the company's strong execution capabilities on a global scale.
- Significant Market Opportunity: Annamycin is poised to become the world's first non-cardiotoxic anthracycline, and given that nearly half of cancer patients currently use cardiotoxic drugs, the market demand potential is enormous, likely attracting increased investor interest.
See More
Moleculin Stock Falls 17% Despite Encouraging Phase 1 WP1066 Results for Pediatric Brain Tumors
Stock Performance: Moleculin Biotech, Inc. (MBRX) shares fell 16.84% to $3.90 despite reporting positive results from a Phase 1 clinical trial of WP1066 for children with recurrent malignant brain tumors.
Clinical Trial Results: The trial indicated that the treatment was safe, induced anti-tumor immune responses, and suppressed STAT3 activity, showing promising signs in a challenging pediatric cancer context.
Market Reaction: Following the announcement, the stock experienced significant volatility and a steep sell-off, with trading activity exceeding average levels as investors reassessed the company's near-term risks.
Trading Range: MBRX's stock trades within a 52-week range of approximately $3.63 to $91.25, highlighting its volatility in the biotech market.
See More
Moleculin's WP1066 Demonstrates Immune Response and Positive Safety Profile in Pediatric Brain Cancer Study
Positive Clinical Trial Results: Moleculin Biotech's Phase 1 trial of WP1066 in children with recurrent malignant brain tumors showed anti-tumor immune activity and a favorable safety profile, with one patient achieving a partial tumor response.
Targeting Aggressive Cancers: The trial focused on aggressive pediatric brain cancers like diffuse midline glioma (DMG) and diffuse intrinsic pontine glioma (DIPG), which have poor survival rates and limited treatment options.
Mechanism of Action: WP1066 is designed to inhibit oncogenic transcription factors and stimulate immune responses against tumors, addressing critical drivers of cancer cell survival and inflammation.
Future Research Plans: Following the promising results, a Phase 2 study is being planned to further evaluate the efficacy and long-term outcomes of WP1066 in pediatric patients.
See More
Moleculin Biotech Increases Enrollment to 78% for MIRACLE Trial
- Enrollment Progress: Moleculin's MIRACLE trial has achieved 78% enrollment of its target subjects, up from 60% in November, with expectations to complete treatment of the first 45 subjects by Q1 2026, laying the groundwork for data unblinding.
- Clinical Activity Tracking: The company reports that blinded clinical activity is tracking within expected ranges, indicating strong enthusiasm from investigators in the US and Europe, particularly as recruitment challenges improve, reflecting a robust market demand for new therapies.
- Trial Design: The MIRACLE trial is a global multi-center, randomized, double-blind, placebo-controlled adaptive design, with plans for preliminary data unblinding at 45 subjects, which could provide strong support for Annamycin's approval if results are favorable.
- Future Outlook: Moleculin anticipates completing recruitment and treatment of 90 subjects in the first half of 2026, further advancing Annamycin's application in acute myeloid leukemia treatment and addressing a significant market gap.
See More
Moleculin Biotech Increases Enrollment to 78% for MIRACLE Trial
- Enrollment Progress: Moleculin's MIRACLE trial enrollment has increased to 78%, up from 60% in November, with expectations to complete treatment of the first 45 subjects by Q1 2026, thereby laying the groundwork for data unblinding.
- Clinical Activity Tracking: The company reports that blinded clinical activity remains within expected ranges, indicating positive responses from investigators, particularly as recruitment improves in the US and Europe.
- Trial Design Advantages: The MIRACLE trial is a global, multi-center, randomized, double-blind, placebo-controlled adaptive design, with the first unblinding set to provide preliminary efficacy data for 45 subjects, potentially offering strong support for Annamycin's approval.
- Market Potential: Annamycin, as a next-generation anticancer drug, has received FDA Fast Track and Orphan Drug Designations, expected to fill a significant gap in acute myeloid leukemia treatment, presenting substantial market opportunities.
See More
Moleculin Launches CEO Corner Platform for Investor Insights
- CEO Corner Launch: Moleculin Biotech announced the launch of its CEO Corner on February 13, 2026, designed to provide deeper insights into corporate developments and clinical progress from CEO Walter Klemp, thereby enhancing trust among investors and stakeholders.
- Clinical Trial Progress: The company is conducting the MIRACLE clinical trial to evaluate Annamycin in combination with cytarabine for treating relapsed acute myeloid leukemia (AML), paving the way for potential drug approval and demonstrating the company's commitment to advancing its pipeline.
- Drug Development Strategy: Annamycin, a next-generation oncology drug, aims to avoid multidrug resistance and reduce cardiotoxicity, expected to provide effective solutions for AML and soft tissue sarcoma, thereby enhancing the company's competitive position in cancer treatment.
- Enhanced Investor Engagement: The CEO Corner platform allows investors to submit questions and topics, facilitating direct communication with the company, reflecting Moleculin's emphasis on transparency and timely communication to enhance long-term shareholder value.
See More
Moleculin Biotech's 2026 MIRACLE Trial Data Unblinding Expected
- Clinical Trial Progress: Moleculin expects to complete the unblinding of data for 45 subjects in the MIRACLE trial in Q1 2026, which is anticipated to provide critical efficacy data for treating acute myeloid leukemia (AML), thereby enhancing Annamycin's market recognition.
- New Indication Expansion: Annamycin is set to initiate a clinical trial for pancreatic cancer in 2026, funded by Atlantic Health, based on preclinical data showing unexpected activity in pancreatic cancer models, further enhancing its market potential.
- Global Trial Network: The MIRACLE trial has expanded to nine countries, including the US and several European nations, with 46 trial sites selected, and is expected to recruit the 90th subject by Q1 2026, demonstrating the company's strong execution capabilities on a global scale.
- Significant Market Opportunity: Annamycin is poised to become the world's first non-cardiotoxic anthracycline, and given that nearly half of cancer patients currently use cardiotoxic drugs, the market demand potential is enormous, likely attracting increased investor interest.
See More
Moleculin Stock Falls 17% Despite Encouraging Phase 1 WP1066 Results for Pediatric Brain Tumors
Stock Performance: Moleculin Biotech, Inc. (MBRX) shares fell 16.84% to $3.90 despite reporting positive results from a Phase 1 clinical trial of WP1066 for children with recurrent malignant brain tumors.
Clinical Trial Results: The trial indicated that the treatment was safe, induced anti-tumor immune responses, and suppressed STAT3 activity, showing promising signs in a challenging pediatric cancer context.
Market Reaction: Following the announcement, the stock experienced significant volatility and a steep sell-off, with trading activity exceeding average levels as investors reassessed the company's near-term risks.
Trading Range: MBRX's stock trades within a 52-week range of approximately $3.63 to $91.25, highlighting its volatility in the biotech market.
See More
Moleculin's WP1066 Demonstrates Immune Response and Positive Safety Profile in Pediatric Brain Cancer Study
Positive Clinical Trial Results: Moleculin Biotech's Phase 1 trial of WP1066 in children with recurrent malignant brain tumors showed anti-tumor immune activity and a favorable safety profile, with one patient achieving a partial tumor response.
Targeting Aggressive Cancers: The trial focused on aggressive pediatric brain cancers like diffuse midline glioma (DMG) and diffuse intrinsic pontine glioma (DIPG), which have poor survival rates and limited treatment options.
Mechanism of Action: WP1066 is designed to inhibit oncogenic transcription factors and stimulate immune responses against tumors, addressing critical drivers of cancer cell survival and inflammation.
Future Research Plans: Following the promising results, a Phase 2 study is being planned to further evaluate the efficacy and long-term outcomes of WP1066 in pediatric patients.
See More
Moleculin Biotech Increases Enrollment to 78% for MIRACLE Trial
- Enrollment Progress: Moleculin's MIRACLE trial has achieved 78% enrollment of its target subjects, up from 60% in November, with expectations to complete treatment of the first 45 subjects by Q1 2026, laying the groundwork for data unblinding.
- Clinical Activity Tracking: The company reports that blinded clinical activity is tracking within expected ranges, indicating strong enthusiasm from investigators in the US and Europe, particularly as recruitment challenges improve, reflecting a robust market demand for new therapies.
- Trial Design: The MIRACLE trial is a global multi-center, randomized, double-blind, placebo-controlled adaptive design, with plans for preliminary data unblinding at 45 subjects, which could provide strong support for Annamycin's approval if results are favorable.
- Future Outlook: Moleculin anticipates completing recruitment and treatment of 90 subjects in the first half of 2026, further advancing Annamycin's application in acute myeloid leukemia treatment and addressing a significant market gap.
See More
Moleculin Biotech Increases Enrollment to 78% for MIRACLE Trial
- Enrollment Progress: Moleculin's MIRACLE trial enrollment has increased to 78%, up from 60% in November, with expectations to complete treatment of the first 45 subjects by Q1 2026, thereby laying the groundwork for data unblinding.
- Clinical Activity Tracking: The company reports that blinded clinical activity remains within expected ranges, indicating positive responses from investigators, particularly as recruitment improves in the US and Europe.
- Trial Design Advantages: The MIRACLE trial is a global, multi-center, randomized, double-blind, placebo-controlled adaptive design, with the first unblinding set to provide preliminary efficacy data for 45 subjects, potentially offering strong support for Annamycin's approval.
- Market Potential: Annamycin, as a next-generation anticancer drug, has received FDA Fast Track and Orphan Drug Designations, expected to fill a significant gap in acute myeloid leukemia treatment, presenting substantial market opportunities.
See More
