Intellia Halts Major Trial Following Severe Liver Incident, Shares Plummet
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Oct 27 2025
0mins
Should l Buy CRSP?
Source: Benzinga
Trial Pause: Intellia Therapeutics has paused patient dosing and screening in its Phase 3 MAGNITUDE trials for its CRISPR therapy, nexiguran ziclumeran (nex-z), due to a serious liver-related adverse event in a participant.
Patient Safety Commitment: The company is working with regulators and medical experts to assess the incident, emphasizing its commitment to patient safety and planning to safely resume enrollment.
Promising Phase 1 Results: Long-term follow-up data from a Phase 1 trial showed significant reductions in transthyretin protein levels and improvements in neuropathy scores among patients treated with nex-z.
Market Impact: Following the announcement of the trial pause, Intellia's shares fell by over 43%, reflecting investor concerns about the implications for the ongoing MAGNITUDE trials.
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Analyst Views on CRSP
Wall Street analysts forecast CRSP stock price to rise
10 Analyst Rating
8 Buy
2 Hold
0 Sell
Strong Buy
Current: 44.340
Low
50.00
Averages
78.89
High
105.00
Current: 44.340
Low
50.00
Averages
78.89
High
105.00
About CRSP
CRISPR Therapeutics AG is a Switzerland-based gene editing company focused on the development of CRISPR/Cas9-based therapeutics. CRISPR/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) and is a technology for gene editing, the process of precisely altering specific sequences of genomic DNA. The Company aims to apply this technology to disrupt, delete, correct and insert genes to treat genetically-defined diseases and to engineer advanced cellular therapies. The Company has acquired the rights to the intellectual property (IP) encompassing CRISPR/Cas9 and related technologies and is also involved in its own IP research and additional in-licensing efforts. The Company product development and partnership strategies are designed to exploit the full potential of the CRISPR/Cas9 platform while maximizing the probability of successfully developing their product candidates.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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