Dogwood Therapeutics Announces Dosing of First Patient in Phase 2b Trial Evaluating Halneuron® in Patients with Chemotherapy-Induced Neuropathic Pain
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Mar 18 2025
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Source: Newsfilter
Dogwood Therapeutics' Clinical Trial: Dogwood Therapeutics has initiated a Phase 2b clinical trial for its non-opioid pain treatment, Halneuron®, targeting chemotherapy-induced neuropathic pain, with plans to recruit 100 patients by late 2025 for interim analysis.
Research and Development Focus: The company is advancing its non-opioid analgesic program alongside an antiviral program aimed at treating conditions like fibromyalgia and Long-COVID, with promising results from previous studies on both fronts.
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Wall Street analysts forecast DWTX stock price to rise
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Current: 3.020
Low
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Averages
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High
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About DWTX
Dogwood Therapeutics, Inc. is a development-stage biopharmaceutical company focused on developing new medicines to treat pain and fatigue-related disorders. The Company’s research pipeline includes two separate mechanistic platforms with a non-opioid analgesic program and an antiviral program. The proprietary, non-opioid, Nav 1.7 analgesic program is centered on its lead development candidate, Halneuron, which is a specific voltage-gated sodium channel modulator, a mechanism known to be effective for reducing pain transmission. In clinical studies, Halneuron treatment has demonstrated pain reduction in pain related to general cancer and in pain related to chronic chemotherapy-induced neuropathic pain (CINP). The Company’s antiviral program includes IMC-1 and IMC-2, which are fixed-dose combinations of nucleoside analog, anti-herpes antivirals and the anti-inflammatory agent celecoxib for the treatment of fibromyalgia (FM) and Long-COVID (LC).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Dogwood Therapeutics Achieves Milestone in HALT-CINP Trial
- Significant Trial Progress: Dogwood Therapeutics has achieved over 50% enrollment in the HALT-CINP Phase 2b trial, with an early termination rate of only 4.3% among 116 patients, indicating good tolerability, and top-line results are expected in Q3 2026.
- Preliminary Clinical Efficacy: An interim analysis of 97 patients showed that Halneuron® treated patients demonstrated significant pain improvement compared to placebo, as confirmed by an independent statistical review committee, highlighting the drug's potential in treating chemotherapy-induced neuropathic pain.
- Statistical Power Assurance: The study is designed to provide over 80% statistical power to detect treatment differences between Halneuron® and placebo upon unblinding in Q3 2026, which could fill the current market gap for approved therapies if successful.
- Future Development Outlook: As a non-opioid NaV1.7 analgesic, Halneuron® has received FDA fast track designation, potentially offering new treatment options for millions of chemotherapy patients and addressing the urgent market need for effective therapies.
See More
Dogwood Therapeutics Raises $12.5 Million to Advance Halneuron® Development
- Funding Amount: Dogwood Therapeutics successfully raised approximately $12.5 million through a registered direct offering and concurrent private placement, which is expected to be utilized for advancing the clinical development of Halneuron®, thereby enhancing the company's innovation in non-opioid medications.
- Equity Structure: The financing involves the issuance of 4,386,037 shares of common stock and corresponding warrants at a price of $2.85 per share, reflecting market recognition of the company's research potential and potentially boosting investor confidence.
- Strategic Use: The company plans to use the net proceeds from the offering to support the Phase 2b clinical trial of Halneuron® while also pursuing strategic opportunities to strengthen its research portfolio, aiming to improve care standards for patients suffering from chemotherapy-induced pain and neuropathy.
- Market Outlook: This financing not only provides Dogwood with additional capital support but also lays the groundwork for future Phase 3 clinical development, further solidifying its market position in the biopharmaceutical industry.
See More
Dogwood Therapeutics Reports Positive Interim Results for Halneuron in Chemotherapy-Induced Neuropathic Pain
- Clinical Trial Progress: Dogwood Therapeutics' Phase 2b trial for chemotherapy-induced neuropathic pain shows that 97 patients experienced significant pain improvement over four weeks, with a dropout rate of only 4.4%, indicating the potential of Halneuron as a viable treatment option.
- Market Need: With no FDA-approved treatments for moderate-to-severe chemotherapy-induced neuropathic pain, Halneuron's success could address a significant unmet medical need for cancer survivors suffering from this debilitating condition.
- Financial Challenges: Despite the encouraging clinical data, Dogwood's stock plummeted nearly 24% due to concerns over its limited cash reserves of $10.1 million, which only provide operational runway through the first quarter of 2026, raising investor apprehensions.
- Future Outlook: The company expects to release top-line results in the third quarter of 2026, and if successful, this could represent the first statistically significant study under FDA chronic pain guidance, potentially paving the way for a Phase 3 registration program.
See More
Dogwood Therapeutics (DWTX) Releases Interim Analysis of Halneuron Phase 2b Study
- Clinical Progress: Dogwood Therapeutics has conducted an interim analysis of its Phase 2b study for Halneuron, indicating the company's ongoing commitment to advancing its R&D pipeline, which may lay the groundwork for future market applications, although specific results have not been disclosed.
- Research Phase: The study aims to evaluate the efficacy and safety of Halneuron as a potential treatment for specific diseases, and successfully completing the interim analysis will provide critical data support for subsequent clinical trials, thereby enhancing investor confidence.
- Market Potential: The successful development of Halneuron could address the unmet demand for new therapies, particularly in treating specific neurological disorders, and positive results would help the company secure a foothold in the competitive biopharmaceutical sector.
- Investor Attention: With the release of the interim analysis, market interest in Dogwood Therapeutics may increase, as investors closely monitor subsequent research outcomes and company strategies to assess its future growth potential.
See More
Dogwood Therapeutics Reports Positive Interim Results for Halneuron®; Top-Line Data Expected Q3 2026
- Clinical Trial Progress: An interim analysis of 97 patients in the ongoing Phase 2b study for chemotherapy-induced neuropathic pain (CINP) shows that Halneuron®-treated patients are significantly improving in pain assessments compared to placebo, indicating the drug's potential in pain management.
- Low Dropout Rate Advantage: The overall dropout rate of approximately 4.4% is significantly lower than that of other FDA-approved chronic pain medications, demonstrating Halneuron®'s favorable tolerability and safety profile, which may enhance patient adherence to treatment.
- Expected Statistical Significance: Current enrollment trends are projected to provide approximately 80% to 85% statistical power to detect treatment differences with Halneuron®, laying the groundwork for a future Phase 3 registration program.
- Market Demand Opportunity: With no approved therapies available for moderate-to-severe neuropathic pain following chemotherapy, the success of Halneuron® could provide a much-needed treatment option for cancer survivors, addressing a critical market need for new therapies.
See More
Dogwood Therapeutics Registers 100 Participants in Halneuron Study for Chemotherapy-Induced Pain
Study Enrollment: Dogwood Therapeutics (DWTX) has successfully enrolled the first 100 patients in its Phase 2b clinical study for Halneur.
Clinical Focus: The study aims to evaluate the efficacy and safety of Halneur in treating specific medical conditions.
See More
Dogwood Therapeutics Achieves Milestone in HALT-CINP Trial
- Significant Trial Progress: Dogwood Therapeutics has achieved over 50% enrollment in the HALT-CINP Phase 2b trial, with an early termination rate of only 4.3% among 116 patients, indicating good tolerability, and top-line results are expected in Q3 2026.
- Preliminary Clinical Efficacy: An interim analysis of 97 patients showed that Halneuron® treated patients demonstrated significant pain improvement compared to placebo, as confirmed by an independent statistical review committee, highlighting the drug's potential in treating chemotherapy-induced neuropathic pain.
- Statistical Power Assurance: The study is designed to provide over 80% statistical power to detect treatment differences between Halneuron® and placebo upon unblinding in Q3 2026, which could fill the current market gap for approved therapies if successful.
- Future Development Outlook: As a non-opioid NaV1.7 analgesic, Halneuron® has received FDA fast track designation, potentially offering new treatment options for millions of chemotherapy patients and addressing the urgent market need for effective therapies.
See More
Dogwood Therapeutics Raises $12.5 Million to Advance Halneuron® Development
- Funding Amount: Dogwood Therapeutics successfully raised approximately $12.5 million through a registered direct offering and concurrent private placement, which is expected to be utilized for advancing the clinical development of Halneuron®, thereby enhancing the company's innovation in non-opioid medications.
- Equity Structure: The financing involves the issuance of 4,386,037 shares of common stock and corresponding warrants at a price of $2.85 per share, reflecting market recognition of the company's research potential and potentially boosting investor confidence.
- Strategic Use: The company plans to use the net proceeds from the offering to support the Phase 2b clinical trial of Halneuron® while also pursuing strategic opportunities to strengthen its research portfolio, aiming to improve care standards for patients suffering from chemotherapy-induced pain and neuropathy.
- Market Outlook: This financing not only provides Dogwood with additional capital support but also lays the groundwork for future Phase 3 clinical development, further solidifying its market position in the biopharmaceutical industry.
See More
Dogwood Therapeutics Reports Positive Interim Results for Halneuron in Chemotherapy-Induced Neuropathic Pain
- Clinical Trial Progress: Dogwood Therapeutics' Phase 2b trial for chemotherapy-induced neuropathic pain shows that 97 patients experienced significant pain improvement over four weeks, with a dropout rate of only 4.4%, indicating the potential of Halneuron as a viable treatment option.
- Market Need: With no FDA-approved treatments for moderate-to-severe chemotherapy-induced neuropathic pain, Halneuron's success could address a significant unmet medical need for cancer survivors suffering from this debilitating condition.
- Financial Challenges: Despite the encouraging clinical data, Dogwood's stock plummeted nearly 24% due to concerns over its limited cash reserves of $10.1 million, which only provide operational runway through the first quarter of 2026, raising investor apprehensions.
- Future Outlook: The company expects to release top-line results in the third quarter of 2026, and if successful, this could represent the first statistically significant study under FDA chronic pain guidance, potentially paving the way for a Phase 3 registration program.
See More
Dogwood Therapeutics (DWTX) Releases Interim Analysis of Halneuron Phase 2b Study
- Clinical Progress: Dogwood Therapeutics has conducted an interim analysis of its Phase 2b study for Halneuron, indicating the company's ongoing commitment to advancing its R&D pipeline, which may lay the groundwork for future market applications, although specific results have not been disclosed.
- Research Phase: The study aims to evaluate the efficacy and safety of Halneuron as a potential treatment for specific diseases, and successfully completing the interim analysis will provide critical data support for subsequent clinical trials, thereby enhancing investor confidence.
- Market Potential: The successful development of Halneuron could address the unmet demand for new therapies, particularly in treating specific neurological disorders, and positive results would help the company secure a foothold in the competitive biopharmaceutical sector.
- Investor Attention: With the release of the interim analysis, market interest in Dogwood Therapeutics may increase, as investors closely monitor subsequent research outcomes and company strategies to assess its future growth potential.
See More
Dogwood Therapeutics Reports Positive Interim Results for Halneuron®; Top-Line Data Expected Q3 2026
- Clinical Trial Progress: An interim analysis of 97 patients in the ongoing Phase 2b study for chemotherapy-induced neuropathic pain (CINP) shows that Halneuron®-treated patients are significantly improving in pain assessments compared to placebo, indicating the drug's potential in pain management.
- Low Dropout Rate Advantage: The overall dropout rate of approximately 4.4% is significantly lower than that of other FDA-approved chronic pain medications, demonstrating Halneuron®'s favorable tolerability and safety profile, which may enhance patient adherence to treatment.
- Expected Statistical Significance: Current enrollment trends are projected to provide approximately 80% to 85% statistical power to detect treatment differences with Halneuron®, laying the groundwork for a future Phase 3 registration program.
- Market Demand Opportunity: With no approved therapies available for moderate-to-severe neuropathic pain following chemotherapy, the success of Halneuron® could provide a much-needed treatment option for cancer survivors, addressing a critical market need for new therapies.
See More
Dogwood Therapeutics Registers 100 Participants in Halneuron Study for Chemotherapy-Induced Pain
Study Enrollment: Dogwood Therapeutics (DWTX) has successfully enrolled the first 100 patients in its Phase 2b clinical study for Halneur.
Clinical Focus: The study aims to evaluate the efficacy and safety of Halneur in treating specific medical conditions.
See More
