B of A Securities Upholds Neutral Rating for Arcus Biosciences (RCUS)
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 29 2025
0mins
Should l Buy RCUS?
Source: NASDAQ.COM
Analyst Recommendation: B of A Securities has maintained a Neutral recommendation for Arcus Biosciences (NYSE:RCUS) as of November 28, 2025, with an average one-year price target of $33.01/share, indicating a potential upside of 26.53% from its current price of $26.09/share.
Financial Projections: The projected annual revenue for Arcus Biosciences is $188 million, reflecting a decrease of 21.63%, while the projected non-GAAP EPS is -4.02.
Institutional Ownership Trends: There are 414 funds reporting positions in Arcus Biosciences, with a slight decrease of 2.59% in ownership over the last quarter, although total shares owned by institutions increased by 0.75% to 111,500K shares.
Shareholder Activity: Gilead Sciences remains the largest shareholder with 25.40% ownership, while Point72 Asset Management and IJR - iShares Core S&P Small-Cap ETF have reduced their holdings, while Woodline Partners increased theirs by 40.31% over the last quarter.
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Analyst Views on RCUS
Wall Street analysts forecast RCUS stock price to rise
9 Analyst Rating
6 Buy
3 Hold
0 Sell
Moderate Buy
Current: 19.960
Low
14.00
Averages
27.44
High
44.00
Current: 19.960
Low
14.00
Averages
27.44
High
44.00
About RCUS
Arcus Biosciences, Inc. is a clinical-stage biopharmaceutical company developing differentiated molecules and combination therapies for people with cancer. The Company has a portfolio of investigational products, which are in clinical development with its advanced molecule, an anti-TIGIT antibody targeting lung and gastrointestinal cancers. The Company has approximately seven clinical programs that are focused on targets, including TIGIT, PD-1, adenosine A2a and A2b receptors, CD73, CD39, HIF-2a, and AXL. The Company is engaged in co-developing four investigational products, including zimberelimab (Arcuss anti-PD-1 molecule), domvanalimab (Arcuss anti-TIGIT antibody), etrumadenant (Arcuss adenosine receptor antagonist) and quemliclustat (Arcuss CD73 inhibitor). It is engaged in pursuing a Phase II and Phase III development program for domvanalimab in combination with its anti-PD-1 antibody, zimberelimab, in multiple settings, including lung and gastrointestinal cancer.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Wall Street Analysts Adjust Ratings
- Analyst Rating Changes: Top Wall Street analysts have adjusted their ratings on several companies, indicating a shift in market sentiment that could influence investor decisions and market trends.
- Overview of Updates: While specific upgrades and downgrades are not detailed, the overall rating changes may prompt investors to reassess their positions, potentially affecting trading volumes and price fluctuations of the related stocks.
- Expected Market Reaction: Analyst rating adjustments typically elicit immediate market responses, and investors should monitor these changes to seize potential investment opportunities or mitigate risks.
- Source of Information: This information is provided by Benzinga, highlighting the significance of analyst ratings in investment decisions, and investors are encouraged to regularly check the analyst ratings page for the latest updates.
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Arcus Biosciences Grants Stock Options to Employees
- Stock Option Grant: Arcus Biosciences granted stock options totaling 16,650 shares to three new employees at an exercise price of $22.13 per share, reflecting the company's commitment to talent retention and motivation.
- Restricted Stock Units: The company also awarded 8,400 shares in restricted stock units, aimed at enhancing employee loyalty and long-term incentives, thereby promoting overall company growth.
- Inducement Plan Context: These equity awards were granted under the company's 2020 Inducement Plan, which was approved by the Board in January 2020, aligning with the NYSE's
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Arcus Advances Casdatifan Phase 3 Trials, Plans Three Data Presentations in 2026
- Clinical Trial Advancement: Arcus is executing its ongoing PEAK-1 Phase 3 trial to establish casdatifan as the standard of care for clear cell renal cell carcinoma, with a goal of rapid patient enrollment to complete the study within 18 months.
- Data Presentation Plans: At least three data presentations for casdatifan are anticipated in 2026, including updated progression-free survival (PFS) data from the ARC-20 study involving 121 patients, to be showcased at a medical conference in February 2026.
- Financial Stability: With approximately $1 billion in cash and investments, Arcus expects to fund its operations until at least the second half of 2028, ensuring the continuity of its development plans.
- New Drug Development: Arcus aims to advance its first small molecule MRGPRX2 antagonist into clinical development in 2026, targeting chronic spontaneous urticaria, highlighting the company's strategic focus in the inflammation and immunology sector.
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Arcus Biosciences President Sells 82,997 Shares for Over $2.05 Million
- Share Sale: Arcus Biosciences President Juan C. Jaen sold 82,997 shares through indirect holdings for $2,050,598, representing 5.91% of total holdings, indicating a larger-than-usual disposition compared to historical trades.
- Holding Changes: Post-transaction, Jaen retains 367,220 shares directly while indirect holdings drop to 954,063 shares, reflecting a significant decrease in indirect ownership and changes in internal liquidity.
- Market Reaction: The sale occurred near the stock's one-year high, and shortly after, the company announced a clinical trial failure, leading to a 14% drop in stock price in a single day, highlighting market uncertainty about the company's future.
- Financial Position: Despite challenges, Arcus maintains approximately $1 billion in cash and has promising early results for its kidney cancer candidate, with critical data expected throughout 2026, potentially offering opportunities for investors.
See More
Arcus Biosciences Insider Sells 82,997 Shares for $2.1 Million Amid Market Highs
- Insider Sale: On December 4, 2025, Arcus Biosciences President Juan C. Jaen sold 82,997 shares through an indirect holding for approximately $2.1 million, reducing his total holdings by 5.91%, indicating potential concerns about the company's future prospects.
- Market Reaction: This transaction occurred just before the company announced the discontinuation of its STAR-221 trial on December 12 due to futility, which triggered a 14% single-day drop in stock price, highlighting the market's sensitivity to the company's outlook.
- Financial Position: Despite the clinical setback, Arcus maintains a robust balance sheet with around $1 billion in cash, and its kidney cancer candidate casdatifan has shown promising early-stage results, with critical late-stage data expected throughout 2026, potentially supporting future growth.
- Investment Risks: As a clinical-stage biotech firm, Arcus carries significant market volatility, with single trial results capable of causing dramatic price swings, making it a potential opportunity for risk-tolerant investors at current levels.
See More
Arcus Overhauls Cancer Development Strategy After Trial Setback, Focuses on Kidney Medication
Discontinuation of STAR-221 Study: Arcus Biosciences has halted the Phase 3 STAR-221 study in collaboration with Gilead Sciences due to futility, as the combination treatment did not show improved overall survival compared to the standard therapy.
Impact on Stock Performance: Following the announcement, Arcus Biosciences' stock (RCUS) fell by 11.10%, reflecting investor concerns over the study's results and future prospects.
Focus on Casdatifan: Arcus will shift its research and development efforts towards casdatifan, a promising HIF-2α inhibitor, which has shown strong efficacy in late-line clear cell renal cell carcinoma patients.
Advancements in Oncology and I&I Pipelines: The company is also progressing with quemliclustat for pancreatic cancer and plans to introduce new oral small-molecule candidates targeting inflammatory conditions by 2026.
See More
Wall Street Analysts Adjust Ratings
- Analyst Rating Changes: Top Wall Street analysts have adjusted their ratings on several companies, indicating a shift in market sentiment that could influence investor decisions and market trends.
- Overview of Updates: While specific upgrades and downgrades are not detailed, the overall rating changes may prompt investors to reassess their positions, potentially affecting trading volumes and price fluctuations of the related stocks.
- Expected Market Reaction: Analyst rating adjustments typically elicit immediate market responses, and investors should monitor these changes to seize potential investment opportunities or mitigate risks.
- Source of Information: This information is provided by Benzinga, highlighting the significance of analyst ratings in investment decisions, and investors are encouraged to regularly check the analyst ratings page for the latest updates.
See More
Arcus Biosciences Grants Stock Options to Employees
- Stock Option Grant: Arcus Biosciences granted stock options totaling 16,650 shares to three new employees at an exercise price of $22.13 per share, reflecting the company's commitment to talent retention and motivation.
- Restricted Stock Units: The company also awarded 8,400 shares in restricted stock units, aimed at enhancing employee loyalty and long-term incentives, thereby promoting overall company growth.
- Inducement Plan Context: These equity awards were granted under the company's 2020 Inducement Plan, which was approved by the Board in January 2020, aligning with the NYSE's
See More
Arcus Advances Casdatifan Phase 3 Trials, Plans Three Data Presentations in 2026
- Clinical Trial Advancement: Arcus is executing its ongoing PEAK-1 Phase 3 trial to establish casdatifan as the standard of care for clear cell renal cell carcinoma, with a goal of rapid patient enrollment to complete the study within 18 months.
- Data Presentation Plans: At least three data presentations for casdatifan are anticipated in 2026, including updated progression-free survival (PFS) data from the ARC-20 study involving 121 patients, to be showcased at a medical conference in February 2026.
- Financial Stability: With approximately $1 billion in cash and investments, Arcus expects to fund its operations until at least the second half of 2028, ensuring the continuity of its development plans.
- New Drug Development: Arcus aims to advance its first small molecule MRGPRX2 antagonist into clinical development in 2026, targeting chronic spontaneous urticaria, highlighting the company's strategic focus in the inflammation and immunology sector.
See More
Arcus Biosciences President Sells 82,997 Shares for Over $2.05 Million
- Share Sale: Arcus Biosciences President Juan C. Jaen sold 82,997 shares through indirect holdings for $2,050,598, representing 5.91% of total holdings, indicating a larger-than-usual disposition compared to historical trades.
- Holding Changes: Post-transaction, Jaen retains 367,220 shares directly while indirect holdings drop to 954,063 shares, reflecting a significant decrease in indirect ownership and changes in internal liquidity.
- Market Reaction: The sale occurred near the stock's one-year high, and shortly after, the company announced a clinical trial failure, leading to a 14% drop in stock price in a single day, highlighting market uncertainty about the company's future.
- Financial Position: Despite challenges, Arcus maintains approximately $1 billion in cash and has promising early results for its kidney cancer candidate, with critical data expected throughout 2026, potentially offering opportunities for investors.
See More
Arcus Biosciences Insider Sells 82,997 Shares for $2.1 Million Amid Market Highs
- Insider Sale: On December 4, 2025, Arcus Biosciences President Juan C. Jaen sold 82,997 shares through an indirect holding for approximately $2.1 million, reducing his total holdings by 5.91%, indicating potential concerns about the company's future prospects.
- Market Reaction: This transaction occurred just before the company announced the discontinuation of its STAR-221 trial on December 12 due to futility, which triggered a 14% single-day drop in stock price, highlighting the market's sensitivity to the company's outlook.
- Financial Position: Despite the clinical setback, Arcus maintains a robust balance sheet with around $1 billion in cash, and its kidney cancer candidate casdatifan has shown promising early-stage results, with critical late-stage data expected throughout 2026, potentially supporting future growth.
- Investment Risks: As a clinical-stage biotech firm, Arcus carries significant market volatility, with single trial results capable of causing dramatic price swings, making it a potential opportunity for risk-tolerant investors at current levels.
See More
Arcus Overhauls Cancer Development Strategy After Trial Setback, Focuses on Kidney Medication
Discontinuation of STAR-221 Study: Arcus Biosciences has halted the Phase 3 STAR-221 study in collaboration with Gilead Sciences due to futility, as the combination treatment did not show improved overall survival compared to the standard therapy.
Impact on Stock Performance: Following the announcement, Arcus Biosciences' stock (RCUS) fell by 11.10%, reflecting investor concerns over the study's results and future prospects.
Focus on Casdatifan: Arcus will shift its research and development efforts towards casdatifan, a promising HIF-2α inhibitor, which has shown strong efficacy in late-line clear cell renal cell carcinoma patients.
Advancements in Oncology and I&I Pipelines: The company is also progressing with quemliclustat for pancreatic cancer and plans to introduce new oral small-molecule candidates targeting inflammatory conditions by 2026.
See More
