Analysts Predict 11% Growth Potential for JHML
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Sep 26 2025
0mins
Should l Buy MDGL?
Source: NASDAQ.COM
ETF Analysis: The John Hancock Multifactor Large Cap ETF (JHML) has an implied analyst target price of $85.71, indicating a potential upside of 10.84% from its current trading price of $77.33.
Notable Holdings: Key underlying holdings with significant upside potential include FTAI Aviation Ltd, Madrigal Pharmaceuticals Inc, and Ionis Pharmaceuticals Inc, each showing expected price increases based on analyst targets.
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Analyst Views on MDGL
Wall Street analysts forecast MDGL stock price to rise
12 Analyst Rating
10 Buy
2 Hold
0 Sell
Strong Buy
Current: 505.340
Low
527.00
Averages
636.22
High
900.00
Current: 505.340
Low
527.00
Averages
636.22
High
900.00
About MDGL
Madrigal Pharmaceuticals, Inc. is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. The Company’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-b agonist designed to target key underlying causes of MASH. Rezdiffra is the medication approved by the United States Food and Drug Administration (FDA) for the treatment of MASH with moderate to advanced fibrosis (consistent with stages F2 to F3). Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver. An ongoing Phase III outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (consistent with stage F4c).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
MDGL Stock Rises Significantly in a Month Amid Eli Lilly Acquisition Rumors
Madrigal's Focus: Madrigal is concentrating on developing therapies for metabolic dysfunction associated with MASH, with its Rezdiffran drug already approved by the U.S. FDA for treating moderate to advanced fibrosis.
Financial Performance: The company reported Rezdiffran sales of $958.4 million for the full year 2025, with over 36,250 patients on the drug by the end of that year.
Expansion Plans: Madrigal has licensed global rights to six pre-clinical siRNA programs for up to $4.4 billion to expand its pipeline and is evaluating the drug for treating compensated MASH cirrhosis.
Market Reaction: Following speculation about a potential buyout by Eli Lilly, Madrigal's stock saw a significant increase, with retail sentiment shifting from neutral to extremely bullish.
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- Madrigal Stock Surge: Madrigal Pharmaceuticals saw a 12% increase in stock price amid renewed speculation of a potential takeover, as traders cited a Betaville report indicating the company has hired advisers for talks with a buyer, reflecting optimistic market sentiment regarding its future.
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Madrigal Pharmaceuticals Shares Surge 12% Amid Takeover Speculation
- Takeover Speculation: Madrigal Pharmaceuticals (MDGL) shares rose 12% amid renewed speculation of a potential acquisition, reflecting investor optimism about the company's future prospects.
- Market Capitalization: With a market cap of $12 billion, Madrigal demonstrates a strong position in the biopharmaceutical sector, attracting interest from potential buyers.
- Short Interest Ratio: Madrigal's short interest stands at 16%, indicating market expectations for stock price volatility, which may influence future investment decisions.
- Future Growth Potential: Madrigal anticipates robust net sales growth in 2026 and an expanding pipeline, coupled with a 50% surge in the MASH market, further enhancing its attractiveness.
See More
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- Market Valuation Changes: Currently, Summit's market cap stands at $12 billion, approximately 48% higher than Axsome and 17% higher than Madrigal, but if the FDA declines ivonescimab, the stock could face a drop of over 20%.
- Competitor Dynamics: Axsome Therapeutics and Madrigal Pharmaceuticals reported revenue growth of 65.5% and 432% in 2025, respectively, indicating strong market potential that could see them surpass Summit in the near future.
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Summit Therapeutics Faces FDA Approval Risk for Ivonescimab
- FDA Approval Crucial: Summit Therapeutics has filed for FDA approval of ivonescimab, which is already approved in China; however, the drug has not shown statistically significant overall survival in Western countries, and a rejection could lead to a significant drop in stock price.
- Intensifying Market Competition: Axsome Therapeutics and Madrigal Pharmaceuticals have market caps of $8.1 billion and $10.2 billion respectively, with both companies poised to potentially surpass Summit by 2026, highlighting the fierce competition in the biotech sector.
- Axsome's Growth Momentum: Axsome Therapeutics reported a 65.5% revenue increase in 2025, reaching $638.5 million, and is awaiting FDA approval for its Alzheimer's drug AXS-05, which could significantly expand its market reach.
- Madrigal's Sales Surge: Madrigal Pharmaceuticals achieved $958.4 million in sales from its Rezdiffra drug in 2025, a 432% increase from 2024, indicating strong growth potential in the metabolic dysfunction space, with expectations for continued excellent financial performance.
See More
MDGL Stock Rises Significantly in a Month Amid Eli Lilly Acquisition Rumors
Madrigal's Focus: Madrigal is concentrating on developing therapies for metabolic dysfunction associated with MASH, with its Rezdiffran drug already approved by the U.S. FDA for treating moderate to advanced fibrosis.
Financial Performance: The company reported Rezdiffran sales of $958.4 million for the full year 2025, with over 36,250 patients on the drug by the end of that year.
Expansion Plans: Madrigal has licensed global rights to six pre-clinical siRNA programs for up to $4.4 billion to expand its pipeline and is evaluating the drug for treating compensated MASH cirrhosis.
Market Reaction: Following speculation about a potential buyout by Eli Lilly, Madrigal's stock saw a significant increase, with retail sentiment shifting from neutral to extremely bullish.
See More
Wall Street Declines Amid Rising U.S.-Iran Tensions
- Market Decline: Wall Street ended lower on Thursday as investors monitored escalating U.S.-Iran tensions, with the Nasdaq Composite down 2.3%, the S&P 500 down 1.7%, and the Dow Jones Industrial Average down 1%, indicating market sensitivity to geopolitical risks.
- Madrigal Stock Surge: Madrigal Pharmaceuticals saw a 12% increase in stock price amid renewed speculation of a potential takeover, as traders cited a Betaville report indicating the company has hired advisers for talks with a buyer, reflecting optimistic market sentiment regarding its future.
- Macy's Mixed Results: Despite reporting positive early results from its Google Gemini-powered chatbot, Macy's stock dipped 0.5%, with data showing customers using the “Ask Macy’s” assistant spent approximately 4.75 times more than those who did not, suggesting cautious market sentiment about its long-term growth potential.
- Modular Medical Stock Split: Modular Medical announced a 1-for-30 reverse stock split effective March 31, 2026, aimed at raising its share price to meet Nasdaq's $1 minimum bid requirement, reducing outstanding shares from approximately 139.8 million to about 4.66 million, highlighting the company's commitment to maintaining its listing status.
See More
Madrigal Pharmaceuticals Shares Surge 12% Amid Takeover Speculation
- Takeover Speculation: Madrigal Pharmaceuticals (MDGL) shares rose 12% amid renewed speculation of a potential acquisition, reflecting investor optimism about the company's future prospects.
- Market Capitalization: With a market cap of $12 billion, Madrigal demonstrates a strong position in the biopharmaceutical sector, attracting interest from potential buyers.
- Short Interest Ratio: Madrigal's short interest stands at 16%, indicating market expectations for stock price volatility, which may influence future investment decisions.
- Future Growth Potential: Madrigal anticipates robust net sales growth in 2026 and an expanding pipeline, coupled with a 50% surge in the MASH market, further enhancing its attractiveness.
See More
U.S. Markets Declined on Thursday; Karman Holdings Experienced Largest Loss
- Stock Market Decline: U.S. stock indexes experienced a decline on Thursday, with significant drops across major indices.
- Index Performance: The S&P 500 fell by 2.38%, the Dow Jones dropped 1.74%, and the Nasdaq decreased by 1.01%.
See More
Summit Therapeutics Faces FDA Review Risk for Ivonescimab
- Regulatory Application Progress: Summit Therapeutics has filed for FDA approval of ivonescimab, which is already approved in China; however, survival data from Western countries has not shown statistical significance, potentially jeopardizing its marketing authorization.
- Market Valuation Changes: Currently, Summit's market cap stands at $12 billion, approximately 48% higher than Axsome and 17% higher than Madrigal, but if the FDA declines ivonescimab, the stock could face a drop of over 20%.
- Competitor Dynamics: Axsome Therapeutics and Madrigal Pharmaceuticals reported revenue growth of 65.5% and 432% in 2025, respectively, indicating strong market potential that could see them surpass Summit in the near future.
- Investor Risk Assessment: While Summit has long-term potential in oncology, its short-term outlook is uncertain, prompting investors to carefully evaluate risks, especially in light of possible negative clinical trial outcomes.
See More
Summit Therapeutics Faces FDA Approval Risk for Ivonescimab
- FDA Approval Crucial: Summit Therapeutics has filed for FDA approval of ivonescimab, which is already approved in China; however, the drug has not shown statistically significant overall survival in Western countries, and a rejection could lead to a significant drop in stock price.
- Intensifying Market Competition: Axsome Therapeutics and Madrigal Pharmaceuticals have market caps of $8.1 billion and $10.2 billion respectively, with both companies poised to potentially surpass Summit by 2026, highlighting the fierce competition in the biotech sector.
- Axsome's Growth Momentum: Axsome Therapeutics reported a 65.5% revenue increase in 2025, reaching $638.5 million, and is awaiting FDA approval for its Alzheimer's drug AXS-05, which could significantly expand its market reach.
- Madrigal's Sales Surge: Madrigal Pharmaceuticals achieved $958.4 million in sales from its Rezdiffra drug in 2025, a 432% increase from 2024, indicating strong growth potential in the metabolic dysfunction space, with expectations for continued excellent financial performance.
See More
