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ALNY Should I Buy

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Intellectia

Should You Buy Alnylam Pharmaceuticals Inc (ALNY) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Hold
Latest Price
330.680
1 Day change
4.62%
52 Week Range
495.550
Analysis Updated At
2026/03/26
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Alnylam Pharmaceuticals Inc (ALNY) is not a strong buy for a beginner, long-term investor at this time. While the company has promising growth in its RNAi platform and collaborations, the stock appears 'priced to perfection' with limited upside in the short term. Analysts' mixed ratings, recent price target downgrades, and declining financial metrics suggest caution. Additionally, no significant trading signals or congress trading data reinforce a hold stance.

Technical Analysis

The MACD is positive and expanding, indicating bullish momentum, but the RSI is neutral at 67.926. Moving averages are bearish (SMA_200 > SMA_20 > SMA_5), suggesting a downward trend. Key resistance is at 328.901, close to the current price, limiting immediate upside potential.

Options Data

Bullish
Open Interest Put-Call Ratio
Bullish
Option Volume Put-Call Ratio

The low put-call ratios indicate bullish sentiment in the options market, but the overall trading volume is low, suggesting limited activity.

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
6
Buy
9

Positive Catalysts

  • Collaborations with Viz.ai and the American Heart Association to enhance early diagnosis and patient care for ATTR-CM.

  • Strong revenue growth in Q4 2025 (up 84.95% YoY).

  • Positive sentiment in the options market with low put-call ratios.

Neutral/Negative Catalysts

  • Analysts' mixed ratings with multiple price target downgrades and concerns about the stock being 'priced to perfection.'

  • Declining financial metrics: Net income dropped by -322.56% YoY, EPS down -310.77% YoY, and gross margin decreased by -8.55% YoY.

  • Bearish moving averages and limited upside potential in the short term.

Financial Performance

In Q4 2025, revenue increased significantly by 84.95% YoY to $1.097 billion. However, net income dropped by -322.56% YoY, EPS fell by -310.77%, and gross margin declined to 75.6% (-8.55% YoY), indicating profitability challenges despite revenue growth.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

Analysts have mixed views. Jefferies downgraded the stock to Hold with a price target of $330, citing concerns about high valuation. Other firms like Canaccord and Freedom Capital maintain Buy ratings but have lowered price targets. Overall, analysts see long-term potential but express caution about near-term headwinds and valuation concerns.

Wall Street analysts forecast ALNY stock price to rise
17 Analyst Rating
Wall Street analysts forecast ALNY stock price to rise
14 Buy
3 Hold
0 Sell
Strong Buy
Current: 316.090
sliders
Low
351
Averages
479.53
High
580
Current: 316.090
sliders
Low
351
Averages
479.53
High
580
Jefferies
Buy
to
Hold
downgrade
$522 -> $330
AI Analysis
2026-03-16
Reason
Jefferies
Price Target
$522 -> $330
AI Analysis
2026-03-16
downgrade
Buy
to
Hold
Reason
Jefferies downgraded Alnylam to Hold from Buy with a price target of $330, down from $522, after assuming coverage of the name. The firm is "impressed" with the company's RNAi platform but says the shares are "priced to perfection." Alnylam's longer term consensus expectations are at risk as they price in big market growth and low competition, the analyst tells investors in a research note.
Canaccord
Buy
maintain
$415 -> $429
2026-02-17
Reason
Canaccord
Price Target
$415 -> $429
2026-02-17
maintain
Buy
Reason
Canaccord raised the firm's price target on Alnylam to $429 from $415 and keeps a Buy rating on the shares. The firm updated its model following Q4 results which was largely uneventful following its January preannouncement of a slight top and bottom line miss. But the bigger picture is that the Amvuttra launch in TTR is going really well and longer term they continue to see upside versus. the company's and Street's estimates.
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