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ALNY Should I Buy

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OverviewStock Price PredictionTechnicalValuationFinancialsEarningsShould I BuyNews & Events
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Intellectia

Should You Buy Alnylam Pharmaceuticals Inc (ALNY) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Hold
Latest Price
295.050
1 Day change
-0.29%
52 Week Range
495.550
Analysis Updated At
2026/05/08
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Alnylam Pharmaceuticals is not a strong buy right now for a Beginner long-term investor, even with $50,000-$100,000 to deploy. The business is growing very fast and the latest quarter was strong, but the stock is already priced for substantial success and the current technical setup is weak. Since the user is impatient and wants a direct answer, my view is to wait rather than buy immediately. If forced to choose today, I would hold and not initiate a new long-term position at this price.

Technical Analysis

The technical picture is bearish to neutral. MACD histogram is negative and expanding, which points to weakening momentum. RSI_6 at 35.5 is near oversold but not yet a clear reversal signal. The moving averages are bearish with SMA_200 above SMA_20 above SMA_5, showing the stock is still in a downtrend. Price at 296.34 is near pivot 302.22 and above S1 290.54, so it is sitting close to support but not showing a confirmed breakout. Overall trend is weak despite some short-term stabilization. Recent pattern data suggests a possible bounce, but not enough to call it a clean long-term entry.

Options Data

Bullish
Open Interest Put-Call Ratio
Bearish
Option Volume Put-Call Ratio

Options sentiment looks mixed but slightly constructive. The open interest put-call ratio of 0.41 is bullish, showing more calls than puts outstanding. However, the option volume put-call ratio of 4.0 is bearish for the day, indicating heavy put buying activity recently. Implied volatility is moderate at 37.09 with IV rank 6.16, so options are not signaling an extreme event premium. Overall, positioning suggests traders are divided rather than strongly bullish.

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
9
Buy
0

Positive Catalysts

  • ["Q1 revenue came in at $1.17B, up 96.43% YoY, showing very strong top-line growth.", "News flow was positive with new vutrisiran data for heart failure/cardiomyopathy support at a major congress.", "Analysts at Bernstein, Canaccord, Truist, and Chardan remain positive on the long-term story, with multiple Buy/Outperform ratings.", "Bernstein said U.S. numbers look very strong and sees continued gains versus competitors.", "The stock has a modeled near-term rebound tendency based on similar candlestick patterns."]

Neutral/Negative Catalysts

  • ["The latest technical trend is bearish, with MACD weak and moving averages stacked negatively.", "Q1 net income and EPS fell sharply year over year despite revenue growth, suggesting margin and cost pressure.", "Gross margin declined year over year to 81.91%.", "Morgan Stanley only rates the stock Equal Weight, and Jefferies downgraded it to Hold, saying the shares are priced to perfection.", "Analysts noted Q1 seasonal weakness in the U.S. from payer dynamics and fewer shipping weeks.", "Options flow shows heavy put volume today, which signals short-term caution.", "No meaningful insider, hedge fund, politician, or congress buying support was reported."]

Financial Performance

Latest quarter: Q1 2026. Revenue was 1.167B, up 96.43% YoY, which is excellent growth and the strongest positive in the report. However, net income fell to 205.99M, EPS dropped to 1.51, and gross margin declined to 81.91%, showing that profitability quality weakened even as sales surged. The quarter was fundamentally strong on growth, but not yet clean on earnings leverage.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

Analyst sentiment is mixed but still constructive overall. Recent target changes are mostly downward adjustments from prior highs, reflecting a more cautious valuation view, but most firms kept bullish ratings. Bernstein, Canaccord, Truist, Freedom Capital, and Chardan are positive, while Morgan Stanley is neutral and Jefferies is cautious with a Hold and a much lower target. The Wall Street pros view is: strong long-term platform and launch momentum, but the stock may already reflect a lot of future growth. That makes the bullish case solid, but the current price still looks demanding.

Wall Street analysts forecast ALNY stock price to rise
17 Analyst Rating
Wall Street analysts forecast ALNY stock price to rise
14 Buy
3 Hold
0 Sell
Strong Buy
Current: 295.910
sliders
Low
351
Averages
479.53
High
580
Current: 295.910
sliders
Low
351
Averages
479.53
High
580
Morgan Stanley
Equal Weight
maintain
$360 -> $370
AI Analysis
2026-05-01
Reason
Morgan Stanley
Price Target
$360 -> $370
AI Analysis
2026-05-01
maintain
Equal Weight
Reason
Morgan Stanley raised the firm's price target on Alnylam to $370 from $360 and keeps an Equal Weight rating on the shares.
Bernstein
Outperform
maintain
$448 -> $447
2026-05-01
Reason
Bernstein
Price Target
$448 -> $447
2026-05-01
maintain
Outperform
Reason
Bernstein lowered the firm's price target on Alnylam to $447 from $448 and keeps an Outperform rating on the shares. The firm notes Amvuttra beat consensus by 5%. Shares ended the day up only 3%, lower than the mid-single digit Bernstein expected, with bear feedback that the beat relied too much on outside-U.S. guide midpoint still requires large step-up in quarter-over-quarter growth. The firm thinks U.S. numbers look very strong with continued gains vs. competitors.
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