
UPB Valuation
Upstream Bio Inc
- Overview
- Forecast
- Valuation
- Earnings
UPB Relative Valuation
UPB's fair value is calculated using relative valuation, based on historical P/E and P/S ranges and their premiums/discounts relative to a competitor average, adjusted by weights. If the market price exceeds this fair value range, UPB is overvalued; if below, it's undervalued.
Historical Valuation
Upstream Bio Inc (UPB) is now in the Overvalued zone, suggesting that its current forward PS ratio of 543.13 is considered Overvalued compared with the five-year average of -4.94. The fair price of Upstream Bio Inc (UPB) is between 5.58 to 14.63 according to relative valuation methord. Compared to the current price of 15.19 USD , Upstream Bio Inc is Overvalued By 3.81%.
Relative Value
Fair Zone
5.58-14.63
Current Price:15.19
3.81%
Overvalued
-4.92
PE
1Y
3Y
5Y
Trailing
Forward
-2.21
EV/EBITDA
Upstream Bio Inc. (UPB) has a current EV/EBITDA of -2.21. The 5-year average EV/EBITDA is -4.02. The thresholds are as follows: Strongly Undervalued below -12.89, Undervalued between -12.89 and -8.45, Fairly Valued between 0.42 and -8.45, Overvalued between 0.42 and 4.86, and Strongly Overvalued above 4.86. The current Forward EV/EBITDA of -2.21 falls within the Historic Trend Line -Fairly Valued range.
-2.13
EV/EBIT
Upstream Bio Inc. (UPB) has a current EV/EBIT of -2.13. The 5-year average EV/EBIT is -3.56. The thresholds are as follows: Strongly Undervalued below -11.37, Undervalued between -11.37 and -7.46, Fairly Valued between 0.34 and -7.46, Overvalued between 0.34 and 4.25, and Strongly Overvalued above 4.25. The current Forward EV/EBIT of -2.13 falls within the Historic Trend Line -Fairly Valued range.
543.13
PS
Upstream Bio Inc. (UPB) has a current PS of 543.13. The 5-year average PS is 403.67. The thresholds are as follows: Strongly Undervalued below -1.01, Undervalued between -1.01 and 201.33, Fairly Valued between 606.00 and 201.33, Overvalued between 606.00 and 808.34, and Strongly Overvalued above 808.34. The current Forward PS of 543.13 falls within the Historic Trend Line -Fairly Valued range.
-6.77
P/OCF
Upstream Bio Inc. (UPB) has a current P/OCF of -6.77. The 5-year average P/OCF is -6.53. The thresholds are as follows: Strongly Undervalued below -14.44, Undervalued between -14.44 and -10.49, Fairly Valued between -2.57 and -10.49, Overvalued between -2.57 and 1.39, and Strongly Overvalued above 1.39. The current Forward P/OCF of -6.77 falls within the Historic Trend Line -Fairly Valued range.
-12.70
P/FCF
Upstream Bio Inc. (UPB) has a current P/FCF of -12.70. The 5-year average P/FCF is -12.01. The thresholds are as follows: Strongly Undervalued below -26.41, Undervalued between -26.41 and -19.21, Fairly Valued between -4.81 and -19.21, Overvalued between -4.81 and 2.40, and Strongly Overvalued above 2.40. The current Forward P/FCF of -12.70 falls within the Historic Trend Line -Fairly Valued range.
Upstream Bio Inc (UPB) has a current Price-to-Book (P/B) ratio of 1.68. Compared to its 3-year average P/B ratio of 0.38 , the current P/B ratio is approximately 348.28% higher. Relative to its 5-year average P/B ratio of 0.38, the current P/B ratio is about 348.28% higher. Upstream Bio Inc (UPB) has a Forward Free Cash Flow (FCF) yield of approximately -10.80%. Compared to its 3-year average FCF yield of -11.24%, the current FCF yield is approximately -3.93% lower. Relative to its 5-year average FCF yield of -11.24% , the current FCF yield is about -3.93% lower.
1.68
P/B
Median3y
0.38
Median5y
0.38
-10.80
FCF Yield
Median3y
-11.24
Median5y
-11.24
Competitors Valuation Multiple
The average P/S ratio for UPB's competitors is 166.87, providing a benchmark for relative valuation. Upstream Bio Inc Corp (UPB) exhibits a P/S ratio of 543.13, which is 225.47% above the industry average. Given its robust revenue growth of -11.56%, this premium appears unsustainable.
P/S
P/E
EV/EBITDA
EV/EBIT
P/S
Revenue Growth
Market Cap

UPB.O
Upstream Bio Inc
543.13
Average P/S: 166.87
-11.56%
817.13M

TNGX.O
Tango Therapeutics Inc
26.52
-16.67%
682.88M

STOK.O
Stoke Therapeutics Inc
36.89
3661.12%
702.66M

TSHA.O
Taysha Gene Therapies Inc
94.79
-32.51%
690.27M

DNTH.O
Dianthus Therapeutics Inc
231.14
33.07%
668.93M

VIR.O
Vir Biotechnology Inc
68.78
-94.62%
724.37M
Performance Decomposition
1Y
3Y
5Y
Market capitalization of UPB decreased by 36.12% over the past 1 year. The primary factor behind the change was an decrease in Margin Expansion from -1.70K to -4.82K.
The secondary factor is the Revenue Growth, contributed -11.56%to the performance.
Overall, the performance of UPB in the past 1 year is driven by Margin Expansion. Which is more sustainable.
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FAQ

Is Upstream Bio Inc (UPB) currently overvalued or undervalued?
Upstream Bio Inc (UPB) is now in the Overvalued zone, suggesting that its current forward PS ratio of 543.13 is considered Overvalued compared with the five-year average of -4.94. The fair price of Upstream Bio Inc (UPB) is between 5.58 to 14.63 according to relative valuation methord. Compared to the current price of 15.19 USD , Upstream Bio Inc is Overvalued By 3.81% .

What is Upstream Bio Inc (UPB) fair value?

How does UPB's valuation metrics compare to the industry average?

What is the current P/B ratio for Upstream Bio Inc (UPB) as of Jul 30 2025?

What is the current FCF Yield for Upstream Bio Inc (UPB) as of Jul 30 2025?

What is the current Forward P/E ratio for Upstream Bio Inc (UPB) as of Jul 30 2025?
