Based on our advanced algorithm, we predict that UPB stock price will experience significant movement in the coming periods. Our 1-day prediction estimates a price of $26.8, while the 1-week outlook suggests a value of $25.59. For the 1-month forecast, we project a price of $27.07. Looking further ahead, our 2026 projection estimates a value of $0.00, with a long-term 2030 forecast reaching $0.00. Stay informed and make strategic decisions with our data-driven insights!
Based on our evaluation of the five key dimensions—Technical Signals, Moving Average trends, Short Sell Data, Similar Chart Pattern Matching and Seasonality Analysis—we have identified the following insights. UPB has several positive signals and is within a rising trend, so we believe it will perform strongly in the next couple of days or weeks. We therefore hold a positive evaluation of this stock. Our analysis conclusion for this stock is a Strong Buy candidate.
UPB stock price ended at $27.14 on Friday, after losing-1.2%
The Upstream Bio Inc stock price decreased by -1.2% on the last trading day (12 Dec 2025), dropping from 28 to 27.14. Throughout the last trading session, the stock experienced a fluctuation of 5.49% , ranging from a day low of $26.78 to a day high of 28.25. The price has declined in 4 of the last 10 days, resulting in a total change of -5.10% during this period. On the last day, trading volume increase by -356.35K shares, with the falling prices. This could serve as an early warning, indicating that risk may slightly increase in the coming days. In total, 305.42K shares were traded, amounting to approximately 8.46M.
UPB Technical Signals
UPB(Upstream Bio Inc Corp) has 2 buy signals and 1 sell signal now. The current trend is an uptrend starting from 2025-11-07. The total price change during this trend is +18.21%. Recently, the price has dropped while volume droped, indicating a potential rebound signal. The average turnover of UPB over the last 5 trading days is 11.54M. Overall, the technical indicator signals lean more toward a Neutral outlook in the mid-term.
UPB Moving Average Analysis
Upstream Bio Inc's overall moving average trend leans more bullish as of Saturday, December 13, 2025, with 1 negative signals and 3 positive signal. In the mid-term, the SMA_20 being above the SMA_60 signals a strong bullish trend. There will be some resistance from the lines at $30.67, and $32.68. A break-up above any of these levels will issue buy signals. There will be some support from the lines at $24.14, and $22.12. A break-down below any of these levels will issue sell signals.
UPB Short Selling Analysis
The short sale ratio of Upstream Bio Inc(UPB) as of 10 Dec 2025 is 16.39%, dropping from last trading day. With decreasing price from 28.36 to 28.67. The short sell activity indicate that short sellers may be experiencing short cover.
Technical Signal
Technical Signals Summary
Sell
1
Buy
2
Moving Average
Swing
Negative
Stock Price Below SMA_5
Short Term
Positive
SMA_5 Above SMA_20
Mid Term
Positive
SMA_20 Above SMA_60
Long Term
Positive
SMA_60 Above SMA_200
Short Selling
Close Price
Short Sale Ratio
Short Sale Volume
2 Bullish Signals
2 Bullish Signals
When Value satisfies Signal, Indicator signals Bullish
Indicators
Signal
Value
Meaning
Awesome Oscillator (5, 34)
AO_5_34 > 0
2.452
Bullish
Moving Average Convergence Divergence (12, 26, 9)
MACD_12_26_9 > 0
1.128
Bullish
1 Bearish Signals
1 Bearish Signals
When Value satisfies Signal, Indicator signals Bearish
In 2026, Upstream Bio Inc (UPB) is anticipated to change hands in a trading channel between $0.00 and $0.00.
Upstream Bio Inc Stock Forecast 2026
UPB Price Prediction & Forecast by Similar Chart Analysis
Based on historical patterns and backtesting of stocks with similar movements to Upstream Bio Inc(UPB), our algorithm predicts UPB's 1-month price at $26.09, with an -5.99%downwardshift. Using a similarity score up to 93.61%and other factors, This forecast updates weekly, adjusting for significant deviations.
Similar Chart
The price prediction chart for Upstream Bio Inc (UPB.O) stock, as of Sunday, December 7, 2025 , forecasts a -5.99% change over the next month, based on its high correlation with ELP.N stock patterns. The similarity between their price movements over the analyzed periods is 93.61%. The right panel lists other stocks with similar price patterns. This prediction is updated every week.
UPB
No Data
ELP
Down: -5.99%Similarity: 93.61%
Name
Similarity
Up/Down
ELP.N
93.61%
-5.99%
LEVI.N
93.06%
-4.23%
ARLP.O
92.72%
-1.38%
ARL.N
92.67%
+14.28%
OGS.N
92.66%
+1.12%
RCI.N
92.39%
-1.37%
LUCD.O
92.27%
-11.02%
CALX.N
92.25%
+24.41%
CWAN.N
92.11%
+17.84%
SNEX.O
92.10%
+3.39%
UPB Seasonality Analysis
Based on UPB's historical stock price data across all years, the probability of a positive return in December is0.00%, suggesting it maynotbe an ideal month to invest in UPB. In contrast,Apriloffers the highest probability of positive returns at100.00%, making it a potentially strong month for investment.
However, this is only a prediction based on one method, and a comprehensive assessment of the stock's future trend should consider additional factors. Our final stock price commentary incorporates three main evaluation dimensions: technical signals, Moving Average trends, and similar chart pattern matching, with the first two dimensions carrying the primary weight to ensure a more robust and accurate forecast.
Monthly Seasonality
The radar chart shows that buying Upstream Bio Inc (UPB.O) stock in April has the highest probability of a positive return (100.00%), while January has the lowest probability (0.00%).
Performance Seasonality
The chart shows Upstream Bio Inc. (UPB)'s annual stock price return for the past three years, helping you analyze price trends and identify recurring trends on an annual basis.
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FAQ
Should I buy Upstream Bio Inc (UPB.O) stock?
Based on our evaluation of the five key dimensions—Technical Signals, Moving Average trends, Short Sell Data, Similar Chart Pattern Matching and Seasonality Analysis—we have identified the following insights. UPB has several positive signals and is within a rising trend, so we believe it will perform strongly in the next couple of days or weeks. We therefore hold a positive evaluation of this stock. Our analysis conclusion for this stock is a Strong Buy candidate.
Which months have the highest win rate for buying Upstream Bio Inc (UPB.O) stock in a year?
The radar chart shows that buying Upstream Bio Inc (UPB.O) stock in April has the highest probability of a positive return (100.00%), while January has the lowest probability (0.00%).
How has Upstream Bio Inc. (UPB)'s stock price performed over the past three years?
UPB's stock price fell by -25.27% in 2024,increased by 66.50% in 2025, and went by in
Bearish technical signals of UPB include: MOM_10 < 0.
Is UPB a buy based on overall technical signals summary?
UPB has 2 buy signals and 1 sell signals now. Overall the technical rating for UPB is Neutral . Note that market conditions change all the time. In addition to technical ratings, keep an eye on the Valuation Level of UPB.
What is the trend of Upstream Bio Inc (UPB)'s moving average?
Upstream Bio Inc's overall moving average trend leans more bullish as of December 13 2025, with 1 negative signals and 3 positive signal.
What is price prediction for UPB stock next month?
The price prediction chart for Upstream Bio Inc (UPB.O) stock, as of December 07 2025, forecasts a -5.99% change over the next month, based on its high correlation with ELP stock patterns. The similarity between their price movements over the analyzed periods is 93.61%. The right panel lists other stocks with similar price patterns. This prediction is updated every week.
What is price prediction 2026 for Upstream Bio Inc (UPB) Stock?
In , Upstream Bio Inc's value is forecasted to reach an average price of $NaN. The price is predicted to fluctuate between a low of $NaN and a high of $NaN.
What is price prediction 2030 for Upstream Bio Inc (UPB) Stock?
In , Upstream Bio Inc's value is forecasted to reach an average price of $NaN. The price is predicted to fluctuate between a low of $NaN and a high of $NaN.