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TVRD Overview

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Intellectia

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High
4.302
Open
4.250
VWAP
4.19
Vol
47.98K
Mkt Cap
39.21M
Low
4.079
Amount
200.92K
EV/EBITDA(TTM)
--
Total Shares
9.38M
EV
8.40M
EV/OCF(TTM)
--
P/S(TTM)
--
Tvardi Therapeutics, Inc., formerly Cara Therapeutics, Inc., is a clinical-stage biopharmaceutical company focused on the development of novel, oral, small molecule therapies targeting (STAT3) to treat fibrosis-driven diseases with significant unmet need. STAT3 is a central mediator across critical fibrotic signaling pathways that drive uncontrolled deposition, proliferation, survival and immune suppression. STAT3 is also positioned at the intersection of many signaling pathways integral to the survival and immune evasion of cancer cells. Its product candidate, TTI-101, is in Phase 2 clinical development for the treatment of fibrosis-driven diseases, with an initial focus on idiopathic pulmonary fibrosis (IPF), and hepatocellular carcinoma (HCC). Its second product candidate, TTI-109, is an oral, small-molecule, which is structurally related to, yet chemically distinct from, TTI-101 and is designed to enhance the ability to target STAT3.
Show More

Events Timeline

(ET)
2026-05-08
07:10:00
Tvardi CEO Expects TTI-109 Data to Inform Clinical Strategy
select
2026-05-01 (ET)
2026-05-01
16:10:00
Tvardi Therapeutics Files $200M Mixed Securities Shelf
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2026-03-31 (ET)
2026-03-31
16:10:00
Tvardi Cash Reserves at $30.8M, Sufficient to Fund Operations Through Q4 2026
select
2026-01-08 (ET)
2026-01-08
08:30:00
Tvardi Therapeutics Updates on TTI-101 Clinical Trial Progress
select
2025-11-13 (ET)
2025-11-13
16:03:51
Tvardi Therapeutics Announces Q3 EPS of 59c, Below Consensus Estimate of 96c
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News

seekingalpha
9.5
05-08seekingalpha
PinnedTvardi Therapeutics Q1 Earnings Report Analysis
  • Earnings Miss: Tvardi Therapeutics reported a Q1 GAAP EPS of -$0.73, missing expectations by $0.04, indicating challenges in profitability that could undermine investor confidence.
  • Cash Position: As of March 31, 2026, the company's cash, cash equivalents, and short-term investments totaled $25.0 million, down from $30.8 million as of December 31, 2025, reflecting increased liquidity pressure.
  • Funding Strategy: Tvardi anticipates that its current cash runway is sufficient to fund operations through clinical readouts and into Q4 2026, indicating a cautious approach to financial management amid future challenges.
  • Market Outlook: Despite financial pressures, Tvardi is actively advancing clinical trials, and successful clinical readouts could present new growth opportunities, enhancing the company's competitive position in the market.
Newsfilter
8.5
05-08Newsfilter
PinnedTvardi Reports Clinical Progress on TTI-109 Inhibitor
  • TTI-109 Study Progress: Tvardi is conducting a healthy volunteer study for TTI-109, with topline data expected in June 2026, which will inform future clinical development strategies and enhance the company's competitive edge in the STAT3 inhibitor market.
  • TTI-101 Clinical Trials: The Phase 1b/2 trial of TTI-101 for hepatocellular carcinoma is on track to report topline results in the second half of 2026, with prior interim findings indicating clinically meaningful activity across various treatment settings, potentially opening new market opportunities for the company.
  • Financial Status Improvement: Research and development expenses for Q1 2026 were $4.9 million, up from $3.1 million in Q1 2025, primarily due to increased costs associated with TTI-109 development, reflecting the company's ongoing investment in advancing its product pipeline.
  • Cash Flow Outlook: As of March 31, 2026, Tvardi reported cash and short-term investments of $25 million, which is expected to be sufficient to fund operations through Q4 2026, ensuring adequate liquidity ahead of clinical readouts and boosting investor confidence.
NASDAQ.COM
9.5
04-01NASDAQ.COM
Tvardi Therapeutics Reports 2025 Financial Results and Pipeline Progress
  • Improved Financial Performance: Tvardi Therapeutics reported a net loss of $7.3 million for Q4 2025, translating to a diluted loss of $0.78 per share, which is a significant improvement from the $12.7 million loss and $4.94 per share in the same quarter of 2024, indicating progress in cost management and operational efficiency.
  • Significant Clinical Progress: The company's STAT3-targeted pipeline, including TTI-109 and TTI-101, is advancing towards multiple key clinical milestones in 2026, with TTI-101 showing clinically meaningful activity in the REVERT LIVER CANCER trial, enhancing investor confidence in its future potential.
  • Stable Cash Flow: Tvardi ended 2025 with $30.8 million in cash and short-term investments, expected to fund operations into Q4 2026, ensuring financial stability during the upcoming clinical data readouts.
  • Equity Structure Adjustment: The company implemented a 1-for-3 reverse stock split on April 14, 2025, aimed at enhancing stock liquidity and market appeal, although the stock price fell by 0.62% to $3.18 on Tuesday, which may impact investor sentiment.
seekingalpha
9.5
03-31seekingalpha
Tvardi Therapeutics Q4 Earnings Miss Expectations
  • Earnings Performance: Tvardi Therapeutics reported a Q4 GAAP EPS of -$0.78, missing expectations by $0.19, indicating challenges in profitability that may affect investor confidence.
  • Cash Position: As of December 31, 2025, Tvardi's cash, cash equivalents, and short-term investments totaled $30.8 million, down from $31.6 million in the same period of 2024, reflecting pressure on the company's financial management.
  • Funding Strategy: The company anticipates that its current cash runway will be sufficient to fund operations as planned through clinical readouts into Q4 2026, indicating a cautious approach to cash utilization to ensure ongoing operations.
  • Future Outlook: Despite financial challenges, Tvardi plans to enhance its market position through advancing clinical trials, which, if successful, could present new growth opportunities for the company.
Globenewswire
2.0
01-08Globenewswire
Tvardi to Present TTI-101 Clinical Data at 44th J.P. Morgan Healthcare Conference
  • Clinical Trial Progress: Tvardi Therapeutics will present new Phase 2 REVERT IPF clinical trial data for TTI-101 at the 44th J.P. Morgan Healthcare Conference on January 15, 2026, demonstrating encouraging signals across fibrosis, inflammatory markers, and pulmonary function, further supporting TTI-101's efficacy in inhibiting STAT3.
  • Market Demand Alignment: TTI-101, an innovative therapy targeting fibrosis-driven diseases, addresses the urgent need for effective treatment options in the clinical landscape, potentially bolstering the company's market position in the biopharmaceutical sector.
  • Investor Engagement: The conference will provide a webcast for investors to access detailed information about TTI-101, likely attracting increased investor interest in Tvardi's clinical advancements and future potential.
  • Strategic Positioning: Tvardi's focus on developing small molecule therapies targeting STAT3 highlights its strategic importance in addressing unmet medical needs in fibrosis diseases, which may present long-term growth opportunities for the company.
Globenewswire
7.0
2025-12-24Globenewswire
Tvardi Therapeutics Shares Plunge 80% Following Disappointing Phase 2 Trial Data
  • Stock Plunge: Tvardi Therapeutics experienced an over 80% drop in share price on October 13, 2025, following disappointing preliminary data from its Phase 2 REVERT clinical trial, which is likely to severely impact investor confidence and may lead to further legal actions.
  • Trial Failure: The trial aimed to assess the safety and efficacy of TTI-101 in patients with idiopathic pulmonary fibrosis, but preliminary results indicated that it did not meet its goals, potentially affecting the company's future R&D direction and funding inflow.
  • Investor Losses: Faruqi & Faruqi LLP is investigating potential claims against Tvardi, encouraging investors who suffered significant losses to reach out, highlighting the legal risks that could exacerbate the financial pressures faced by the company.
  • Market Reaction: The poor clinical trial results may lead to substantial losses for Tvardi's shareholders, further impacting the company's reputation and market position within the biopharmaceutical industry.
Wall Street analysts forecast TVRD stock price to rise
6 Analyst Rating
Wall Street analysts forecast TVRD stock price to rise
2 Buy
4 Hold
0 Sell
Moderate Buy
Current: 0.000
sliders
Low
4.00
Averages
9.00
High
15.00
Current: 0.000
sliders
Low
4.00
Averages
9.00
High
15.00
Barclays
Equal Weight -> Underweight
downgrade
$4 -> $3
AI Analysis
2026-04-20
Reason
Barclays
Price Target
$4 -> $3
AI Analysis
2026-04-20
downgrade
Equal Weight -> Underweight
Reason
Barclays downgraded Tvardi Therapeutics to Underweight from Equal Weight with a price target of $3, down from $4. The company's funding overhang makes the story "incrementally more challenged" in 2026, the analyst tells investors in a research note. Barclays sees additional risks to the story with the pushout of Tvardi 's Phase 2 REVERT hepatocellular carcinoma study of TTI-101 from to the second half of 2026 relative to the company's cash guidance of "through 4Q 2026."
Piper Sandler
Piper Sandler
Neutral
downgrade
$4 -> $3
2026-04-01
Reason
Piper Sandler
Piper Sandler
Price Target
$4 -> $3
2026-04-01
downgrade
Neutral
Reason
Piper Sandler lowered the firm's price target on Tvardi Therapeutics to $3 from $4 and keeps a Neutral rating on the shares. At Q4/FY25 earnings, Tvardi reiterated TTI-109's Phase 1 HVs is on track for topline and color on next steps in Q2 2026, which the firm expects to be a key catalyst to guide future development of the company's second-generation STAT3 inhibitor. At readout, Piper expects the disclosure will provide insight into TTI-109's differentiated PK/PD, ability to rapidly convert into TTI-101, and exposure rates, which will be crucial to inform future development.
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Valuation Metrics

The current forward P/E ratio for Tvardi Therapeutics Inc (TVRD.O) is 0.00, compared to its 5-year average forward P/E of -5.60. For a more detailed relative valuation and DCF analysis to assess Tvardi Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-5.60
Current PE
0.00
Overvalued PE
-1.37
Undervalued PE
-9.84

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.00
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.00
Undervalued EV/EBITDA
0.00

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
0.00
Current PS
0.00
Overvalued PS
0.00
Undervalued PS
0.00

Financials

AI Analysis
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Quarterly

Whales Holding TVRD

S
Slate Path Capital LP
Holding
TVRD
+22.80%
3M Return

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Frequently Asked Questions

What is Tvardi Therapeutics Inc (TVRD) stock price today?

The current price of TVRD is 4.18 USD — it has decreased -0.71

What is Tvardi Therapeutics Inc (TVRD)'s business?

Tvardi Therapeutics, Inc., formerly Cara Therapeutics, Inc., is a clinical-stage biopharmaceutical company focused on the development of novel, oral, small molecule therapies targeting (STAT3) to treat fibrosis-driven diseases with significant unmet need. STAT3 is a central mediator across critical fibrotic signaling pathways that drive uncontrolled deposition, proliferation, survival and immune suppression. STAT3 is also positioned at the intersection of many signaling pathways integral to the survival and immune evasion of cancer cells. Its product candidate, TTI-101, is in Phase 2 clinical development for the treatment of fibrosis-driven diseases, with an initial focus on idiopathic pulmonary fibrosis (IPF), and hepatocellular carcinoma (HCC). Its second product candidate, TTI-109, is an oral, small-molecule, which is structurally related to, yet chemically distinct from, TTI-101 and is designed to enhance the ability to target STAT3.

What is the price predicton of TVRD Stock?

Wall Street analysts forecast TVRD stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for TVRD is9.00 USD with a low forecast of 4.00 USD and a high forecast of 15.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Tvardi Therapeutics Inc (TVRD)'s revenue for the last quarter?

Tvardi Therapeutics Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Tvardi Therapeutics Inc (TVRD)'s earnings per share (EPS) for the last quarter?

Tvardi Therapeutics Inc. EPS for the last quarter amounts to -0.77 USD, decreased -84.41

How many employees does Tvardi Therapeutics Inc (TVRD). have?

Tvardi Therapeutics Inc (TVRD) has 12 emplpoyees as of May 11 2026.

What is Tvardi Therapeutics Inc (TVRD) market cap?

Today TVRD has the market capitalization of 39.21M USD.