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SPRB Overview

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$
0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
70.250
Open
69.000
VWAP
64.89
Vol
38.21K
Mkt Cap
86.49M
Low
61.390
Amount
2.48M
EV/EBITDA(TTM)
--
Total Shares
1.37M
EV
37.59M
EV/OCF(TTM)
--
P/S(TTM)
--
Spruce Biosciences, Inc. is a late-stage biopharmaceutical company focused on developing and commercializing therapies for neurological disorders with significant unmet medical need. The Company has acquired an exclusive worldwide license agreement for tralesinidase alfa enzyme replacement therapy (TA-ERT) for the treatment of Sanfilippo Syndrome Type B (MPS IIIB). The TA-ERT is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) with modified human insulin-like growth factor 2 via an amino acid linker. TA-ERT is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB who lack rhNAGLU enzyme activity. The Company's pipeline also includes Tildacerfont and Cortibon for the treatment of Major Depressive Disorder, SPR202 for the treatment of Congenital Adrenal Hyperplasia and SPR204 for the treatment of Post-Bariatric Hypoglycemia.
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Events Timeline

(ET)
2026-03-27
11:40:00
Biotech Stocks Surge in Search Activity, Radiopharm Up 2566.66%
select
2026-03-09 (ET)
2026-03-09
07:30:00
Spruce Biosciences Appoints Dale Hooks as Chief Commercial Officer
select
2026-02-18 (ET)
2026-02-18
08:00:00
Spruce Biosciences Completes FDA Type B Meetings, Plans BLA Submission in Q4 2026
select
2026-01-19 (ET)
2026-01-19
15:10:00
Harbour BioMed Acquires 3.8% Stake in Spruce Biosciences
select

News

NASDAQ.COM
2.0
03-25NASDAQ.COM
Precious Metals Stocks Surge, Led by Aura Minerals
  • Precious Metals Surge: Precious metals stocks collectively rose by approximately 3.3%, indicating strong market confidence in the sector, likely reflecting investors' demand for safe-haven assets amid economic uncertainty.
  • Aura Minerals Leads: Aura Minerals saw its stock price increase by about 6.8%, making it one of the top performers of the day, suggesting its competitive position in the precious metals market and positive investor sentiment.
  • SSR Mining Follows Suit: SSR Mining's stock rose by approximately 6.6%, demonstrating the company's solid performance in the precious metals sector, which may attract more investor interest in its future growth potential.
  • Biotech and Precious Metals Thrive: On Wednesday, both biotechnology and precious metals stocks showed strong performance, indicating investors' preference for diversified portfolios, potentially leading to increased capital inflows for related companies.
moomoo
7.5
03-20moomoo
SPRUCE BIOSCIENCES INC - TERMINATION OF ALL LICENSES AND RIGHTS GRANTED TO KAKEN; NO UNRECEIVED MILESTONE PAYMENTS OR ROYALTIES DUE
  • Licenses and Rights: The article discusses the granting of licenses and rights by Cotokaken, emphasizing the importance of these in the context of scientific research and development.

  • Termination of Agreements: It highlights that certain agreements or licenses may be terminated, which could impact ongoing projects or collaborations.

  • Financial Implications: The piece notes that there are no earned milestone payments associated with the licenses, indicating a potential financial strain or lack of revenue generation.

  • Royalty Ties: It mentions the absence of royalty ties, suggesting that the agreements do not include provisions for ongoing financial returns based on sales or usage of the licensed products.

moomoo
7.5
03-20moomoo
SPRUCE BIOSCIENCES INC ANNOUNCES TERMINATION AGREEMENT WITH KAKEN PHARMACEUTICAL ON MARCH 16 - SEC FILING
  • Termination Agreement: Spruce Biosciences has entered into a termination agreement with Kaken Pharmaceutical, signaling a significant change in their partnership.

  • Impact on Operations: This agreement may affect Spruce's ongoing projects and future collaborations in the pharmaceutical sector.

seekingalpha
9.5
03-09seekingalpha
Spruce Biosciences Reports Disappointing FY EPS and Cash Position
  • Disappointing Earnings: Spruce Biosciences reported a FY GAAP EPS of -$50.83, missing expectations by $29.59, indicating significant financial challenges that may undermine investor confidence.
  • Cash Position: As of December 31, 2025, the company had $48.9 million in cash and cash equivalents, excluding $15 million in gross proceeds from a loan facility with Avenue Capital, highlighting its reliance on external financing.
  • Funding for Operations: The company expects its current cash reserves to fund its operating plan into early 2027, beyond the anticipated BLA submission for TA-ERT, providing some financial stability for future product development.
  • Growth Capital Pursuit: Spruce Biosciences is seeking up to $50 million in growth capital, aimed at enhancing its financial flexibility and supporting future business expansion despite its current disappointing financial performance.
Newsfilter
8.5
03-09Newsfilter
Spruce Biosciences Advances TA-ERT for MPS IIIB Treatment
  • Positive FDA Meetings: Spruce Biosciences successfully held two Type B meetings with the FDA, confirming that clinical data for TA-ERT could serve as a reasonable surrogate endpoint for accelerated approval, with a BLA submission anticipated in Q4 2026, potentially providing the first treatment option for MPS IIIB patients and significantly enhancing the company's market outlook.
  • Executive Appointment: The company appointed Dale Hooks as Chief Commercial Officer, who brings over 30 years of marketing experience in the rare disease sector to drive the commercialization of TA-ERT, enhancing the company's competitive edge in the upcoming product launch and demonstrating strong confidence in future growth.
  • Funding Support: Spruce Biosciences secured a loan facility with Avenue Capital for up to $50 million in growth capital, with an initial tranche of $15 million fully funded in January 2026, which will support the continued development and potential commercial launch of TA-ERT, ensuring the company's financial stability.
  • Financial Performance: As of December 31, 2025, the company reported cash and cash equivalents of $48.9 million, expected to fund operations into early 2027, while R&D expenses decreased to $19.5 million compared to 2024, reflecting effective resource allocation and focus on core projects.
stocktwits
8.5
02-18stocktwits
Spruce Biosciences Delays FDA Submission Timeline
  • Submission Delay: Spruce Biosciences announced a delay in its FDA submission for enzyme replacement therapy to Q4 2026, pushing back from the previously expected Q1 2026, which may impact its competitiveness in the rare disease market.
  • FDA Meeting Progress: The company has held two meetings with the FDA, discussing clinical data and regulatory strategy in the first meeting, while the second focused on chemistry, manufacturing, and controls (CMC) requirements, indicating proactive engagement with regulators during the application process.
  • Confidence in Clinical Data: Despite the delayed submission, CEO Javier Szwarcberg expressed confidence in the long-term data for TA-ERT, asserting that significant clinical benefits in cognition, communication, and motor skills could drive future market acceptance of the therapy.
  • Market Sentiment Analysis: Although shares fell 8% due to the delay, retail sentiment around Spruce Biosciences stock remained in the 'bullish' territory on Stocktwits over the past 24 hours, reflecting investor confidence in the company's future potential.
Wall Street analysts forecast SPRB stock price to rise
4 Analyst Rating
Wall Street analysts forecast SPRB stock price to rise
4 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
160.00
Averages
230.50
High
283.00
Current: 0.000
sliders
Low
160.00
Averages
230.50
High
283.00
Citizens
Outperform
downgrade
$180 -> $170
AI Analysis
2026-03-10
Reason
Citizens
Price Target
$180 -> $170
AI Analysis
2026-03-10
downgrade
Outperform
Reason
Citizens lowered the firm's price target on Spruce Biosciences to $170 from $180 and keeps an Outperform rating on the shares. The firm continues to like Tralesinidase Alfa Enzyme Replacement Therapy's opportunity in Sanfilippo Syndrome Type B and views the path to approval as relatively derisked in the ultra-rare disease, the analyst tells investors in a research note.
H.C. Wainwright
Raghuram Selvaraju
Buy
downgrade
$220 -> $200
2026-02-19
Reason
H.C. Wainwright
Raghuram Selvaraju
Price Target
$220 -> $200
2026-02-19
downgrade
Buy
Reason
H.C. Wainwright analyst Raghuram Selvaraju lowered the firm's price target on Spruce Biosciences to $200 from $220 and keeps a Buy rating on the shares. The firm says the timing for completion of the tralesinidase alfa enzyme replacement therapy filing is now anticipated in Q4 versus Q1 previously.
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Valuation Metrics

The current forward P/E ratio for Spruce Biosciences, Inc (SPRB.O) is -2.17, compared to its 5-year average forward P/E of -1.70. For a more detailed relative valuation and DCF analysis to assess Spruce Biosciences, Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-1.70
Current PE
-2.17
Overvalued PE
0.13
Undervalued PE
-3.53

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-0.07
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.89
Undervalued EV/EBITDA
-1.03

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
-66.64
Current PS
0.00
Overvalued PS
241.61
Undervalued PS
-374.89

Financials

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Frequently Asked Questions

What is Spruce Biosciences, Inc (SPRB) stock price today?

The current price of SPRB is 63.04 USD — it has decreased -8.78

What is Spruce Biosciences, Inc (SPRB)'s business?

Spruce Biosciences, Inc. is a late-stage biopharmaceutical company focused on developing and commercializing therapies for neurological disorders with significant unmet medical need. The Company has acquired an exclusive worldwide license agreement for tralesinidase alfa enzyme replacement therapy (TA-ERT) for the treatment of Sanfilippo Syndrome Type B (MPS IIIB). The TA-ERT is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) with modified human insulin-like growth factor 2 via an amino acid linker. TA-ERT is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB who lack rhNAGLU enzyme activity. The Company's pipeline also includes Tildacerfont and Cortibon for the treatment of Major Depressive Disorder, SPR202 for the treatment of Congenital Adrenal Hyperplasia and SPR204 for the treatment of Post-Bariatric Hypoglycemia.

What is the price predicton of SPRB Stock?

Wall Street analysts forecast SPRB stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for SPRB is230.50 USD with a low forecast of 160.00 USD and a high forecast of 283.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Spruce Biosciences, Inc (SPRB)'s revenue for the last quarter?

Spruce Biosciences, Inc revenue for the last quarter amounts to 0.00 USD, decreased -100.00

What is Spruce Biosciences, Inc (SPRB)'s earnings per share (EPS) for the last quarter?

Spruce Biosciences, Inc. EPS for the last quarter amounts to -11.28 USD, decreased -73.51

How many employees does Spruce Biosciences, Inc (SPRB). have?

Spruce Biosciences, Inc (SPRB) has 8 emplpoyees as of March 30 2026.

What is Spruce Biosciences, Inc (SPRB) market cap?

Today SPRB has the market capitalization of 86.49M USD.