Loading...

Intellectia LogoIntellectia
AI Trading Bot
Features
Markets
News
Resources
Pricing
  1. Home
  2. Stock
  3. SPRB
SPRB logo

SPRB Overview

-
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
OverviewStock Price PredictionTechnicalValuationFinancialsEarningsShould I BuyNews & Events
an image of Intellectia Logoan image of Intellectia

Most Trusted AI Platform for Winning Trades

TwitterYoutubeQuoraDiscordLinkedinTelegram

Copyright © 2026 Intellectia.AI. All Rights Reserved.

Company

  • Home
  • Contact
  • About Us
  • Press
  • Privacy
  • Terms of Service
  • Service Terms of Use

Resources

  • Blog
  • Tutorial
  • Help Center
  • Affiliate Program

Markets

  • Market Analysis
  • Crypto
  • Featured Screeners
  • AI Earnings Calendar
  • Market Movers
  • Stock Monitor
  • Economic Calendar
  • All US Stocks
  • All Cryptos

Tools

  • Dividend Calculator
  • Dividend Yield Calculator
  • Options Profit Calculator

Features

  • QuantAI Alpha Pick
  • SwingMax Portfolio
  • Swing Trading
  • AI Stock Picker
  • Whales Auto Tracker
  • Daytrading Center
  • Patterns Detection
  • AI Screener
  • Financial AI Agent
  • Backtesting Playground
  • AI Earnings Prediction
  • Stock Monitor
  • Technical Analysis

News

  • Overview
  • Top News
  • Daily Market Brief
  • Earnings Analysis
  • Newswire
  • Stock News
  • Crypto News
  • Institution News
  • Congress News
  • Monitor News

Compare

  • TradingView
  • SeekingAlpha
Intellectia

Loading chart...

High
64.605
Open
52.470
VWAP
59.73
Vol
77.12K
Mkt Cap
66.48M
Low
52.470
Amount
4.61M
EV/EBITDA(TTM)
--
Total Shares
1.07M
EV
49.67M
EV/OCF(TTM)
--
P/S(TTM)
34.27
Spruce Biosciences, Inc. is a late-stage biopharmaceutical company focused on developing and commercializing therapies for neurological disorders with significant unmet medical need. The Company has acquired an exclusive worldwide license agreement for tralesinidase alfa enzyme replacement therapy (TA-ERT) for the treatment of Sanfilippo Syndrome Type B (MPS IIIB). The TA-ERT is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) with modified human insulin-like growth factor 2 via an amino acid linker. TA-ERT is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB who lack rhNAGLU enzyme activity. The Company's pipeline also includes Tildacerfont and Cortibon for the treatment of Major Depressive Disorder, SPR202 for the treatment of Congenital Adrenal Hyperplasia and SPR204 for the treatment of Post-Bariatric Hypoglycemia.
Show More

Events Timeline

(ET)
2026-03-09
07:30:00
Spruce Biosciences Appoints Dale Hooks as Chief Commercial Officer
select
2026-02-18 (ET)
2026-02-18
08:00:00
Spruce Biosciences Completes FDA Type B Meetings, Plans BLA Submission in Q4 2026
select
2026-01-19 (ET)
2026-01-19
15:10:00
Harbour BioMed Acquires 3.8% Stake in Spruce Biosciences
select
2025-12-03 (ET)
2025-12-03
12:30:00
Polyrizon Sees 5,728.31% Surge in Search Activity
select

News

seekingalpha
9.5
03-09seekingalpha
PinnedSpruce Biosciences Reports Disappointing FY EPS and Cash Position
  • Disappointing Earnings: Spruce Biosciences reported a FY GAAP EPS of -$50.83, missing expectations by $29.59, indicating significant financial challenges that may undermine investor confidence.
  • Cash Position: As of December 31, 2025, the company had $48.9 million in cash and cash equivalents, excluding $15 million in gross proceeds from a loan facility with Avenue Capital, highlighting its reliance on external financing.
  • Funding for Operations: The company expects its current cash reserves to fund its operating plan into early 2027, beyond the anticipated BLA submission for TA-ERT, providing some financial stability for future product development.
  • Growth Capital Pursuit: Spruce Biosciences is seeking up to $50 million in growth capital, aimed at enhancing its financial flexibility and supporting future business expansion despite its current disappointing financial performance.
Newsfilter
8.5
03-09Newsfilter
PinnedSpruce Biosciences Advances TA-ERT for MPS IIIB Treatment
  • Positive FDA Meetings: Spruce Biosciences successfully held two Type B meetings with the FDA, confirming that clinical data for TA-ERT could serve as a reasonable surrogate endpoint for accelerated approval, with a BLA submission anticipated in Q4 2026, potentially providing the first treatment option for MPS IIIB patients and significantly enhancing the company's market outlook.
  • Executive Appointment: The company appointed Dale Hooks as Chief Commercial Officer, who brings over 30 years of marketing experience in the rare disease sector to drive the commercialization of TA-ERT, enhancing the company's competitive edge in the upcoming product launch and demonstrating strong confidence in future growth.
  • Funding Support: Spruce Biosciences secured a loan facility with Avenue Capital for up to $50 million in growth capital, with an initial tranche of $15 million fully funded in January 2026, which will support the continued development and potential commercial launch of TA-ERT, ensuring the company's financial stability.
  • Financial Performance: As of December 31, 2025, the company reported cash and cash equivalents of $48.9 million, expected to fund operations into early 2027, while R&D expenses decreased to $19.5 million compared to 2024, reflecting effective resource allocation and focus on core projects.
stocktwits
8.5
02-18stocktwits
Spruce Biosciences Delays FDA Submission Timeline
  • Submission Delay: Spruce Biosciences announced a delay in its FDA submission for enzyme replacement therapy to Q4 2026, pushing back from the previously expected Q1 2026, which may impact its competitiveness in the rare disease market.
  • FDA Meeting Progress: The company has held two meetings with the FDA, discussing clinical data and regulatory strategy in the first meeting, while the second focused on chemistry, manufacturing, and controls (CMC) requirements, indicating proactive engagement with regulators during the application process.
  • Confidence in Clinical Data: Despite the delayed submission, CEO Javier Szwarcberg expressed confidence in the long-term data for TA-ERT, asserting that significant clinical benefits in cognition, communication, and motor skills could drive future market acceptance of the therapy.
  • Market Sentiment Analysis: Although shares fell 8% due to the delay, retail sentiment around Spruce Biosciences stock remained in the 'bullish' territory on Stocktwits over the past 24 hours, reflecting investor confidence in the company's future potential.
moomoo
9.0
02-18moomoo
SPRUCE BIOSCIENCES STOCK JUMPS 8.16% AS COMPANY PREPARES FOR FDA FILING ON RARE PEDIATRIC BRAIN DISORDER TREATMENT
  • Stock Price Increase: Spruce Biosciences shares have risen by 8.16% following recent developments.

  • Filing for Rare Disorder: The company is moving towards filing for a drug related to a rare childhood brain disorder.

NASDAQ.COM
8.5
02-18NASDAQ.COM
Spruce Biosciences Reports Positive FDA Meeting Outcomes for TA-ERT
  • FDA Meeting Outcomes: Spruce Biosciences received positive feedback from two Type B meetings with the FDA, confirming that integrated clinical and natural history data could support its biologics license application (BLA) for TA-ERT, providing crucial backing for drug development in rare diseases.
  • Accelerated Approval Pathway: The FDA agreed that CSF HS-NRE could serve as a reasonable surrogate endpoint for accelerated approval, recommending enhancements to surrogate evidence in the upcoming BLA, which could expedite TA-ERT's market entry to meet urgent treatment needs for rare diseases.
  • Manufacturing Requirements Adjusted: During the second meeting, the FDA requested data from one drug product process performance qualification (PPQ) batch at BLA submission and a second PPQ batch before mid-cycle review, prompting Spruce to anticipate BLA submission in Q4 2026 to comply with these requirements.
  • Positive Market Reaction: Despite a 12.14% drop to $58.25 on Tuesday, Spruce's stock rebounded by 21.90% to $71.00 in pre-market trading on Wednesday, reflecting investor optimism about the company's future prospects, particularly in the potential market opportunities for rare pediatric disease treatments.
Newsfilter
8.5
02-18Newsfilter
Spruce Biosciences Advances TA-ERT BLA Submission Following FDA Feedback
  • FDA Meeting Outcomes: Spruce Biosciences successfully held two Type B meetings with the FDA, confirming that clinical and natural history data for TA-ERT could serve as a reasonable surrogate endpoint for accelerated approval, indicating positive progress in drug development.
  • BLA Submission Timeline Adjustment: To meet the FDA's requirement for drug product process performance qualification (PPQ) batches, the Biologics License Application (BLA) for TA-ERT is now anticipated to be submitted in Q4 2026, ensuring compliance with regulatory standards.
  • Clinical Data Support: The CEO stated that TA-ERT's data on reducing cerebral spinal fluid heparan sulfate non-reducing end (CSF HS-NRE) indicates significant clinical benefits in cognition, communication, and motor skills, potentially positioning it as the first disease-modifying treatment option for MPS IIIB.
  • Rare Disease Incentive Policy: With the reauthorization of the Rare Pediatric Disease Priority Review Voucher (PRV) program, Spruce Biosciences has gained a crucial incentive for developing therapies for rare diseases, enhancing the company's market prospects in the treatment of MPS IIIB.
Wall Street analysts forecast SPRB stock price to rise
4 Analyst Rating
Wall Street analysts forecast SPRB stock price to rise
4 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
160.00
Averages
230.50
High
283.00
Current: 0.000
sliders
Low
160.00
Averages
230.50
High
283.00
H.C. Wainwright
Raghuram Selvaraju
Buy
downgrade
$220 -> $200
AI Analysis
2026-02-19
Reason
H.C. Wainwright
Raghuram Selvaraju
Price Target
$220 -> $200
AI Analysis
2026-02-19
downgrade
Buy
Reason
H.C. Wainwright analyst Raghuram Selvaraju lowered the firm's price target on Spruce Biosciences to $200 from $220 and keeps a Buy rating on the shares. The firm says the timing for completion of the tralesinidase alfa enzyme replacement therapy filing is now anticipated in Q4 versus Q1 previously.
H.C. Wainwright
initiated
$220
2025-12-22
Reason
H.C. Wainwright
Price Target
$220
2025-12-22
initiated
Reason
H.C. Wainwright assumed coverage of Spruce Biosciences with a Buy rating and $220 price target. The company is developing tralesinidase alfa enzyme replacement therapy for the treatment of Sanfilippo syndrome type B, the analyst tells investors in a research note. The firm sees potential for accelerated review. It believes TA-ERT could achieve peak sales of over $150M in the U.S. alone.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for SPRB
Unlock Now

Valuation Metrics

The current forward P/E ratio for Spruce Biosciences Inc (SPRB.O) is -2.17, compared to its 5-year average forward P/E of -1.80. For a more detailed relative valuation and DCF analysis to assess Spruce Biosciences Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-1.80
Current PE
-2.17
Overvalued PE
0.24
Undervalued PE
-3.84

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-0.19
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
1.24
Undervalued EV/EBITDA
-1.61

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
-65.78
Current PS
0.00
Overvalued PS
240.57
Undervalued PS
-372.14

Financials

AI Analysis
Annual
Quarterly

Related Community Screener

Find stocks with low float
Intellectia · 2888 candidates
Region: USShares Outstanding: <= 150,000,000
Ticker
Name
Market Cap$
top bottom
ADTX logo
ADTX
Aditxt Inc
2.59M
GWAV logo
GWAV
Greenwave Technology Solutions Inc
4.33M
GDHG logo
GDHG
Golden Heaven Group Holdings Ltd
5.19M
AREB logo
AREB
American Rebel Holdings Inc
3.47M
IPW logo
IPW
iPower Inc
5.62M
WTO logo
WTO
UTime Ltd
1.44M
for stocks not crypto
Intellectia · 21 candidates
Market Cap: <= 200.00BPrice Change Pct: >= $10.00Beta: HighRisk
Ticker
Name
Market Cap$
top bottom
MRNA logo
MRNA
Moderna Inc
19.46B
RMBS logo
RMBS
Rambus Inc
13.56B
SFBS logo
SFBS
ServisFirst Bancshares Inc
4.78B
LCID logo
LCID
Lucid Group Inc
3.72B
DAN logo
DAN
Dana Inc
3.53B
TMC logo
TMC
TMC the metals company Inc
3.38B

Whales Holding SPRB

Trading Trends

    Insider
    Hedge Fund
    Congress Trading

People Also Watch

Frequently Asked Questions

What is Spruce Biosciences Inc (SPRB) stock price today?

The current price of SPRB is 62.11 USD — it has increased 11.17

What is Spruce Biosciences Inc (SPRB)'s business?

Spruce Biosciences, Inc. is a late-stage biopharmaceutical company focused on developing and commercializing therapies for neurological disorders with significant unmet medical need. The Company has acquired an exclusive worldwide license agreement for tralesinidase alfa enzyme replacement therapy (TA-ERT) for the treatment of Sanfilippo Syndrome Type B (MPS IIIB). The TA-ERT is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase (rhNAGLU) with modified human insulin-like growth factor 2 via an amino acid linker. TA-ERT is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB who lack rhNAGLU enzyme activity. The Company's pipeline also includes Tildacerfont and Cortibon for the treatment of Major Depressive Disorder, SPR202 for the treatment of Congenital Adrenal Hyperplasia and SPR204 for the treatment of Post-Bariatric Hypoglycemia.

What is the price predicton of SPRB Stock?

Wall Street analysts forecast SPRB stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for SPRB is230.50 USD with a low forecast of 160.00 USD and a high forecast of 283.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Spruce Biosciences Inc (SPRB)'s revenue for the last quarter?

Spruce Biosciences Inc revenue for the last quarter amounts to 0.00 USD, decreased -100.00

What is Spruce Biosciences Inc (SPRB)'s earnings per share (EPS) for the last quarter?

Spruce Biosciences Inc. EPS for the last quarter amounts to -14.58 USD, decreased -7.43

How many employees does Spruce Biosciences Inc (SPRB). have?

Spruce Biosciences Inc (SPRB) has 21 emplpoyees as of March 10 2026.

What is Spruce Biosciences Inc (SPRB) market cap?

Today SPRB has the market capitalization of 66.48M USD.