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SPRB Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
57.500
Open
57.500
VWAP
56.73
Vol
25.16K
Mkt Cap
152.68M
Low
56.200
Amount
1.43M
EV/EBITDA(TTM)
--
Total Shares
2.70M
EV
103.76M
EV/OCF(TTM)
--
P/S(TTM)
--
Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing therapies for neurological disorders with significant unmet medical need. It has a diverse portfolio of product candidates addressing diseases with high unmet medical need and clear biology for treatment, for which there are either no approved therapies treating the underlying disease or suboptimal treatment options. Its pipeline consists of TA-ERT, Tildacerfont and Cortibon, and SPR202. TA-ERT is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase. TA-ERT is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB who lack rhNAGLU enzyme activity. Tildacerfont has the potential to address hyperactive brain corticotropin-releasing factors neurotransmission and aberrant functioning of the hypothalamus-pituitary-adrenal axis in patients with MDD. SPR202 focuses on the treatment of Congenital Adrenal Hyperplasia and other indications.
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Events Timeline

(ET)
2026-05-04
08:20:00
Spruce Biosciences Appoints New Executives
select
2026-04-20 (ET)
2026-04-20
19:40:00
Oil Prices Surge to $90 per Barrel Amid Strait of Hormuz Tensions
select
2026-04-20
16:50:00
Spruce Biosciences Shares Down 13% to $60.50 After Equity Offering Announcement
select
2026-04-20
16:10:00
Spruce Biosciences Launches Underwritten Public Offering
select
2026-03-27 (ET)
2026-03-27
11:40:00
Biotech Stocks Surge in Search Activity, Radiopharm Up 2566.66%
select

News

moomoo
5.0
05-04moomoo
SPRUCE BIOSCIENCES ENHANCES ITS COMMERCIAL LEADERSHIP WITH THE ADDITION OF BRIAN WALLS AS VICE PRESIDENT OF MARKET ACCESS AND DARREN JOHNSON AS VICE PRESIDENT OF COMMERCIAL OPERATIONS
  • New Appointments: Spruce Biosciences strengthens its leadership team with the appointments of Brian Walls as Vice President of Market Access and Darren Johnson as Vice President of Commercial Operations.

  • Focus on Commercial Leadership: The new appointments aim to enhance Spruce Biosciences' commercial strategy and operations, positioning the company for future growth in the biosciences sector.

moomoo
8.5
04-21moomoo
SPRUCE BIOSCIENCES STOCK FALLS 18.1% FOLLOWING EQUITY OFFERING PRICING ANNOUNCEMENT
  • Stock Performance: Spruce Biosciences shares fell by 18.1% following the announcement of their equity offering.
  • Market Reaction: The decline in share price indicates investor concern or reaction to the new equity offering pricing.
NASDAQ.COM
8.5
04-21NASDAQ.COM
Spruce Biosciences Prices Public Offering at $50 per Share
  • Offering Size: Spruce Biosciences has priced its public offering at $50 per share for 1.15 million shares, expecting gross proceeds of $60 million, which will support its research in neurological disorder therapies.
  • Pre-Funded Warrants: The company is also offering pre-funded warrants for 50,000 shares at $49.99 each, enhancing investor participation and potentially attracting more capital inflow.
  • Underwriter Arrangement: Leerink Partners, Guggenheim Securities, and Oppenheimer & Co. are acting as joint book-running managers, indicating market confidence in the offering, which is expected to close on April 22, 2026.
  • Stock Price Volatility: Despite closing at $69.89, the stock fell 21.95% in pre-market trading to $54.55, reflecting a negative market reaction to the offering news, which may impact investor confidence.
NASDAQ.COM
8.5
04-21NASDAQ.COM
Spruce Biosciences Prices Public Offering to Raise $60 Million
  • Fundraising Details: Spruce Biosciences has priced a public offering of 1.15 million common shares at $50.00 each, aiming to raise $60 million to advance its neurological disorder therapies, indicating a significant investment in R&D.
  • Investor Options: Certain investors will receive pre-funded warrants to purchase 50,000 shares at $49.99, reflecting a strategic pricing approach that allows flexibility in capital raising while minimizing dilution.
  • Underwriter's Option: The underwriters have a 30-day option to purchase up to 180,000 additional shares, which could enhance the total capital raised and provide a buffer against market fluctuations.
  • Stock Price Reaction: Following the announcement, Spruce Biosciences' shares fell 12.15% in after-hours trading to $61.40, indicating a negative market reaction that could impact investor sentiment and future fundraising efforts.
seekingalpha
8.5
04-21seekingalpha
Spruce Biosciences Prices Public Offering at $50 per Share
  • Public Offering Pricing: Spruce Biosciences has priced its public offering of 1.15 million common stock shares at $50.00 each, expecting total gross proceeds of $60 million, indicating the company's ability to raise capital in the market.
  • Pre-Funded Warrants: The company is also offering pre-funded warrants for 50,000 shares at $49.99 each to a specific investor, a strategy aimed at attracting investment and enhancing liquidity.
  • Additional Share Option: Spruce Biosciences has granted underwriters a 30-day option to purchase up to 180,000 additional shares, which could further increase the total financing and meet market demand.
  • Stock Price Reaction: Following the public offering announcement, Spruce Biosciences' stock price fell 13.44% in after-hours trading to $60.50, reflecting market caution regarding the offering.
Newsfilter
8.5
04-21Newsfilter
Spruce Biosciences Prices Public Offering at $50 per Share
  • Offering Size: Spruce Biosciences announced a public offering of 1,150,000 shares at $50.00 per share, expecting gross proceeds of $60 million, reflecting the company's strong fundraising capability and market confidence in the biopharmaceutical sector.
  • Pre-Funded Warrant Arrangement: The offering includes pre-funded warrants for 50,000 shares at a purchase price of $49.99 per share for a specific investor, indicating the company's flexible financing strategy to attract investment.
  • Underwriter Lineup: The offering is managed by Leerink Partners, Guggenheim Securities, and Oppenheimer & Co. as joint book-running managers, showcasing the company's strong backing and professionalism in capital markets.
  • Registration Statement Validity: The offering is conducted under a shelf registration statement on Form S-3 filed on October 29, 2025, and declared effective by the SEC on November 26, 2025, ensuring compliance and transparency in the fundraising process.
Wall Street analysts forecast SPRB stock price to rise
4 Analyst Rating
Wall Street analysts forecast SPRB stock price to rise
4 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
160.00
Averages
230.50
High
283.00
Current: 0.000
sliders
Low
160.00
Averages
230.50
High
283.00
Craig-Hallum
Buy
initiated
$140
AI Analysis
2026-04-27
Reason
Craig-Hallum
Price Target
$140
AI Analysis
2026-04-27
initiated
Buy
Reason
AS previously reported, Craig-Hallum initiated coverage of Spruce Biosciences (SPRB) with a Buy rating and $140 price target. The firm notes the company's TA-ERT is an enzyme replacement therapy for MPS IIIB, an ultra-rare neurodegenerative disease that has no treatments and patients typically die in their teens. TA-ERT is on track for a BLA filing for accelerated approval based on a Phase I/II study that showed normalization of CSF HS-NRE. TA-ERT's regulatory path is de-risked following the recent approval of Denali Therapeutics ' (DNLI) Avlayah, which was based on a similar biomarker endpoint. Craig-Hallum sees an attractive set up with a clear path toward approval in a rare pediatric disease setting with strong commercial comps.
Craig-Hallum
Albert Lowe
initiated
$140
2026-04-27
Reason
Craig-Hallum
Albert Lowe
Price Target
$140
2026-04-27
initiated
Reason
Craig-Hallum analyst Albert Lowe initiated coverage of Spruce Biosciences with a Buy rating and $140 price target.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for SPRB
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Valuation Metrics

The current forward P/E ratio for Spruce Biosciences, Inc (SPRB.O) is 0.00, compared to its 5-year average forward P/E of -1.56. For a more detailed relative valuation and DCF analysis to assess Spruce Biosciences, Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-1.56
Current PE
0.00
Overvalued PE
0.07
Undervalued PE
-3.19

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.02
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.77
Undervalued EV/EBITDA
-0.74

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
-29.85
Current PS
2.00
Overvalued PS
178.73
Undervalued PS
-238.44

Financials

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Frequently Asked Questions

What is Spruce Biosciences, Inc (SPRB) stock price today?

The current price of SPRB is 56.5 USD — it has decreased -0.12

What is Spruce Biosciences, Inc (SPRB)'s business?

Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing therapies for neurological disorders with significant unmet medical need. It has a diverse portfolio of product candidates addressing diseases with high unmet medical need and clear biology for treatment, for which there are either no approved therapies treating the underlying disease or suboptimal treatment options. Its pipeline consists of TA-ERT, Tildacerfont and Cortibon, and SPR202. TA-ERT is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase. TA-ERT is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB who lack rhNAGLU enzyme activity. Tildacerfont has the potential to address hyperactive brain corticotropin-releasing factors neurotransmission and aberrant functioning of the hypothalamus-pituitary-adrenal axis in patients with MDD. SPR202 focuses on the treatment of Congenital Adrenal Hyperplasia and other indications.

What is the price predicton of SPRB Stock?

Wall Street analysts forecast SPRB stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for SPRB is230.50 USD with a low forecast of 160.00 USD and a high forecast of 283.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Spruce Biosciences, Inc (SPRB)'s revenue for the last quarter?

Spruce Biosciences, Inc revenue for the last quarter amounts to 0.00 USD, decreased -100.00

What is Spruce Biosciences, Inc (SPRB)'s earnings per share (EPS) for the last quarter?

Spruce Biosciences, Inc. EPS for the last quarter amounts to -11.28 USD, decreased -73.51

How many employees does Spruce Biosciences, Inc (SPRB). have?

Spruce Biosciences, Inc (SPRB) has 8 emplpoyees as of May 10 2026.

What is Spruce Biosciences, Inc (SPRB) market cap?

Today SPRB has the market capitalization of 152.68M USD.