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PYPD Should I Buy

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Intellectia

Should You Buy PolyPid Ltd (PYPD) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Hold
Latest Price
4.390
1 Day change
52 Week Range
5.120
Analysis Updated At
2026/04/03
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PolyPid Ltd (PYPD) is not a strong buy at the moment for a beginner investor with a long-term strategy. While there are positive catalysts such as the FDA Fast Track designation and promising Phase 3 trial results, the company's financial performance is weak, with declining net income and EPS. Additionally, technical indicators and options data do not provide a compelling entry point for long-term investment. Holding off for further developments or financial improvement is advisable.

Technical Analysis

The MACD is positive and expanding, indicating a bullish momentum. RSI is neutral at 60.824, and moving averages are bullish (SMA_5 > SMA_20 > SMA_200). However, the stock's recent candlestick pattern suggests a 30% chance of declining in the short term (-2.84% in the next day, -3.37% in the next week, -3.9% in the next month). Key support and resistance levels are Pivot: 4.255, R1: 4.423, S1: 4.087, R2: 4.527, S2: 3.983.

Options Data

Bullish
Open Interest Put-Call Ratio
Bearish
Option Volume Put-Call Ratio

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
2
Buy
7

Positive Catalysts

  • PolyPid submitted a New Drug Application for D-PLEX₁₈₀₀ to the FDA, which has received Fast Track designation. The drug showed a 60% relative risk reduction in surgical site infections during Phase 3 trials. The company is also negotiating a U.S. commercialization partnership.

Neutral/Negative Catalysts

  • Weak financial performance with declining net income (-0.55% YoY) and EPS (-63.72% YoY). No significant hedge fund or insider trading trends. Congress trading data is unavailable. Stock trend analysis suggests a potential short-term decline.

Financial Performance

In Q4 2025, revenue remained at 0 with no growth YoY. Net income dropped to -$8.47M (-0.55% YoY), and EPS fell to -0.41 (-63.72% YoY). Gross margin remained at 0 with no improvement.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

No recent analyst ratings or price target changes are available for PYPD.

Wall Street analysts forecast PYPD stock price to rise
3 Analyst Rating
Wall Street analysts forecast PYPD stock price to rise
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 4.390
sliders
Low
9
Averages
11
High
13
Current: 4.390
sliders
Low
9
Averages
11
High
13
Roth Capital
Buy
downgrade
$10 -> $9
AI Analysis
2025-11-13
Reason
Roth Capital
Price Target
$10 -> $9
AI Analysis
2025-11-13
downgrade
Buy
Reason
Roth Capital lowered the firm's price target on PolyPid to $9 from $10 and keeps a Buy rating on the shares following the Q3 report. The firm expects a positive pre-new drug application meeting and a potential filing submission in the first half of 2026 for PolyPid. Given that D-PLEX100 "enjoys multiple designations" from the FDA, it should get a six-month review, the analyst tells investors in a research note.
Roth Capital
Buy
maintain
$9 -> $10
2025-08-14
Reason
Roth Capital
Price Target
$9 -> $10
2025-08-14
maintain
Buy
Reason
Roth Capital raised the firm's price target on PolyPid to $10 from $9 and keeps a Buy rating on the shares after meeting with its management following the company's Q2 results. The firm expects a fairly uneventful pre-NDA meeting given solid D-PLEX100 clinical data, which Roth believes is poised to transform the treatment paradigm in SSI associated with colorectal cancer surgery, providing benefits to patients and healthcare systems, the analyst tells investors in a research note.
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