NVO News & Events

Novo Nordisk announced an update to the Singapore label for semaglutide, approved in Singapore as Wegovy injection, incorporating clinical evidence from the STEP UP trial in adults living with obesity without diabetes. In the trial, which evaluated a higher dose of semaglutide, up to one in three participants receiving the higher dose achieved at least 25% weight loss over 72 weeks, while mean weight loss reached 21%. These findings highlight both the magnitude of weight loss and the importance of how weight is reduced, including meaningful improvements in body composition, offering healthcare professionals another option to support patients in their clinical care. Additional analyses from the STEP UP trial showed that reduction in fat mass constitute up to 84% of weight loss, highlighting improvements in body composition. The trial also demonstrated patients' reduction in sudden, impulsive loss of control when seeing or thinking about food. This supports other real-world data about people taking semaglutide for weight management experiencing a substantial drop in food noise.

Vivani Medical (VANI) announced the signing of a new agreement with Novo Nordisk (NVO) to enable Novo Nordisk to evaluate NPM-139, the company's semaglutide drug implant. NPM-139, which utilizes Vivani's NanoPortal platform technology, is under development for chronic weight management. There are no exclusivity provisions for NPM-139, or Vivani's proprietary NanoPortal technology associated with this agreement. Separately, Vivani expects to initiate a Phase 1, randomized, first-in-human study evaluating the NPM-139 semaglutide implant, with Wegovy injections as an active comparator, in mid-2026. The study's objectives are to characterize the safety, pharmacokinetics, and tolerability of NPM-139 to support the initiation of a Phase 2 dose-ranging study pending successful results of the Phase 1 study.