KYMR News & Events

Kymera Therapeutics announced that the FDA has granted fast track designation to KT-621, its oral STAT6 degrader, for the treatment of moderate to severe eosinophilic asthma. KT-621 is currently being studied in two global Phase 2b studies, including for the treatment of moderate to severe eosinophilic asthma.

Kymera Therapeutics (KYMR) announced that Gilead Sciences (GILD) has exercised its option to exclusively license KT-200, oral CDK2 molecular glue degrader development candidate discovered and characterized by Kymera, under their strategic collaboration agreement. As a result, Kymera will realize a $45M milestone payment. Gilead will progress the program into IND-enabling studies to support an IND filing in 2027. CDK2-directed molecular glue degraders represent a novel therapeutic approach designed to selectively remove CDK2, a key driver of tumor growth, rather than just inhibiting its function whilst sparing other CDK family proteins. CDK2 acts as a cyclin E binding partner and drives disease in CCNE1 amplified and over expressed cancers. Traditional CDK2 inhibitors can lack specificity and interfere with closely related proteins, leading to undesired side effects. Degraders have the potential to provide more precise, safe, effective, oral treatments for cancers that rely on CDK2 activity, with the potential to meaningfully improve outcomes for patients, including those with advanced breast cancer where treatment options remain limited. In preclinical testing, KT-200 demonstrated low-nanomolar degradation of CDK2, robust activity in CCNE1 amplified, overexpressed cell lines and in vivo tumor models, brain penetrant potential, and a favorable safety profile. Under the terms of the agreement, Kymera is eligible to receive up to $750M in total payments. To date, Kymera has realized $85M in upfront and option exercise payments. In addition, Kymera may also receive tiered royalties ranging from high single-digit to mid-teens on net product sales under the collaboration. Gilead has global rights to develop, manufacture and commercialize all products resulting from the collaboration.

Kymera Therapeutics announced that the positive results from the BroADen Phase 1b atopic dermatitis, AD, clinical trial of KT-621, its first-in-class, oral STAT6 degrader, were featured in a late-breaking oral presentation at the American Academy of Dermatology, AAD, Annual Meeting. The meeting is being held March 27-31, 2026, in Denver, CO. Data shared at AAD from the BroADen Phase 1b single-arm, open-label trial showed consistent impact across multiple pharmacodynamic and clinical measures evaluated in 22 patients with moderate-to-severe AD. After 28 days of once-daily oral dosing, KT-621 demonstrated deep STAT6 degradation across both the 100 and 200 mg dose groups tested, with median reductions of 94% in skin and 98% in blood. KT-621 also showed robust reductions in disease-relevant Type 2 inflammatory biomarkers in blood, including median TARC reduction of 74% in patients with baseline levels comparable to dupilumab studies, up to 73% reduction of Eotaxin-3, up to 56% reduction of IL-31, and up to 14% reduction of IgE. These biological effects translated into encouraging clinical activity with similar results across both dose groups. KT-621 demonstrated an overall mean 63% reduction in EASI, 29% EASI-75 and 19% vIGA-AD of 0 or 1, 49% reduction in BSA, and 40% reduction in peak pruritus NRS, reflecting improvements in both skin lesion severity and burden as well as itch. There was also an overall mean 9-point reduction in POEM, demonstrating a clinically meaningful improvement in patient-assessed disease severity. KT-621 was well tolerated with a favorable safety profile.