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HOWL Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
0.750
Open
0.732
VWAP
0.73
Vol
372.10K
Mkt Cap
35.57M
Low
0.693
Amount
270.87K
EV/EBITDA(TTM)
--
Total Shares
48.54M
EV
-2.49M
EV/OCF(TTM)
--
P/S(TTM)
--
Werewolf Therapeutics, Inc. is a biopharmaceutical company engaged in the development of therapeutics engineered to stimulate the body’s immune system for the treatment of cancer and other immune-mediated conditions. It is leveraging its PREDATOR platform to design conditionally activated molecules that stimulate both adaptive and innate immunity with the goal of addressing the limitations of conventional proinflammatory immune therapies. Its INDUKINE molecules are intended to remain inactive in peripheral tissue yet activate selectively in the tumor microenvironment. The Company’s advanced clinical-stage product candidates, WTX-124 and WTX-330, are systemically delivered, conditionally activated Interleukin-2 (IL-2) and IL-12 INDUKINE molecules for the treatment of solid tumors. It is advancing WTX-124 in multiple tumor types as a single agent and in combination with an immune checkpoint inhibitor. It is advancing WTX-712, WTX-518, and WTX-921 through preclinical development.
Show More

Events Timeline

(ET)
2026-02-24
19:40:00
Werewolf Therapeutics Explores Strategic Alternatives to Enhance Shareholder Value
select
2026-02-13 (ET)
2026-02-13
16:30:00
Werewolf Therapeutics Cuts 64% Workforce, Expects $4.1M One-Time Charge
select
2025-12-18 (ET)
2025-12-18
08:20:00
Werewolf Therapeutics Updates on INDUKINE Programs
select

News

stocktwits
5.0
02-13stocktwits
Werewolf Therapeutics Cuts Workforce by 64% to Reduce Costs
  • Workforce Reduction: Werewolf Therapeutics announced a 64% workforce cut to lower operating costs, with the reduction expected to be “substantially completed” by February 13, indicating an urgent response to financial pressures.
  • One-Time Charge: The company anticipates incurring a one-time charge of $4.1 million in Q1, covering employee separation benefits including severance, which will negatively impact its short-term financial outlook.
  • Executive Departures: CFO Timothy W. Trost and CMO Randi Isaacs will resign, receiving severance equal to nine months of their base salary, highlighting the risks associated with executive turnover during the restructuring process.
  • Strategic Evaluation: The company is evaluating strategic partnerships for further development of its WTX-124 and WTX-330 INDUKINE programs, although there is no guarantee of successful financing or transactions, reflecting challenges in securing operational funding.
Yahoo Finance
2.0
02-13Yahoo Finance
Werewolf Therapeutics Board Approves Key Decision
  • Board Decision: Werewolf Therapeutics announced on Friday in a regulatory filing that its board has approved a significant decision, although specific details remain undisclosed, this move could impact the company's future strategic direction.
  • Regulatory Filing Submission: The announcement was made through a regulatory filing, indicating the company's commitment to transparency and compliance, which may enhance investor confidence.
  • Market Reaction Anticipation: While specific details are currently unavailable, the market's reaction to the board's decision could influence Werewolf Therapeutics' stock performance, prompting investors to closely monitor subsequent information.
  • Strategic Implications: The board's approval may signal a major shift in the company's R&D or business expansion efforts, reflecting its focus on future growth opportunities.
NASDAQ.COM
2.0
01-05NASDAQ.COM
GH Research (GHRS) Stock Surges 22.36% Ahead of Key Update
  • Stock Surge: GH Research PLC's stock surged 22.36% to $16.20, gaining $2.96, primarily driven by investor anticipation for a key company update scheduled for January 5, 2026.
  • Key Update Announcement: The company will disclose the status of its Investigational New Drug Application (IND) for GH001 and progress on its global pivotal Phase 3 program for treatment-resistant depression (TRD), which is expected to have significant implications for the treatment landscape.
  • Investor Interest Spike: The strong investor interest surrounding the upcoming announcement has led to a substantial increase in GH Research's stock price, reflecting heightened market confidence in the biotech sector.
  • Positive Market Reaction: Despite no new updates from other biotech firms like Phathom Pharmaceuticals and Forte Biosciences, their stock prices also rose, indicating a broader optimistic sentiment in the biotechnology industry.
Globenewswire
3.5
2025-12-18Globenewswire
Werewolf Reports 30% Response Rate for WTX-124 Monotherapy in Melanoma Patients
  • Clinical Data Highlight: WTX-124 demonstrated a 30% overall response rate as a monotherapy in post-ICI advanced melanoma patients, indicating its potential as a best-in-class tolerability drug.
  • Efficacy Validation: Initial data from WTX-330 further confirmed its antitumor activity and favorable tolerability, building on the first-in-human trial, showcasing its prospects in challenging tumor types.
  • Future Development Plans: The Phase 1/1b trial for WTX-124 is expected to complete in the first half of 2026, with additional data updates planned, potentially requiring further funding to initiate a registration trial.
  • Strategic Partnership Opportunities: Werewolf is seeking strategic partners to advance the WTX-124 and WTX-330 INDUKINE programs, leveraging its unique INDUCER T cell engager platform to enhance market competitiveness.
NASDAQ.COM
2.0
2025-12-03NASDAQ.COM
Biotech Stocks Rise After Hours: Clene Jumps Ahead of ALS Update; Werewolf, Biomea, and Dyne Also Gain
  • Clene Inc. Gains: Clene Inc. shares rose 8.53% in after-hours trading after announcing an upcoming investor call regarding its CNM-Au8 program for ALS, despite a regular session decline.

  • Werewolf Therapeutics Update: Werewolf Therapeutics saw a 6.12% increase after hours, likely influenced by investor reactions to its recent presentation at a cancer immunotherapy conference, despite no new news.

  • Biomea Fusion Presentation: Biomea Fusion's stock climbed 7.31% after hours following its announcement of an upcoming presentation on icovamenib data at a major diabetes and cardiovascular disease congress.

  • General Market Trends: Other biotech companies like Denali Therapeutics, TScan Therapeutics, and Nyxoah also experienced after-hours gains, reflecting ongoing investor interest and positioning ahead of regulatory milestones and presentations.

NASDAQ.COM
2.0
2025-11-28NASDAQ.COM
Biotech Stocks MODD, LAB, HOWL, COGT, LGVN, and ABCL Surge in After-Hours Trading - Nov 26
  • Biotech Stocks Surge: Several biotech and life sciences companies experienced significant gains in after-hours trading on November 26, indicating strong investor interest despite a lack of major news.

  • Modular Medical's Approval: Modular Medical, Inc. saw an 11.51% increase in share price after receiving Institutional Review Board approval for its Pivot insulin delivery system study, which aims to gather critical data on device usability.

  • Standard BioTools Collaboration: Standard BioTools Inc. advanced 4.90% following a strategic partnership announcement with Molecular Instruments to enhance protein imaging capabilities through next-generation Imaging Mass Cytometry workflows.

  • Ongoing Investor Optimism: Companies like Werewolf Therapeutics, Cogent Biosciences, and Longeveron also reported gains, reflecting continued investor confidence in their research and development efforts, despite no new corporate updates.

Wall Street analysts forecast HOWL stock price to rise
4 Analyst Rating
Wall Street analysts forecast HOWL stock price to rise
2 Buy
2 Hold
0 Sell
Moderate Buy
Current: 0.000
sliders
Low
1.00
Averages
4.00
High
7.00
Current: 0.000
sliders
Low
1.00
Averages
4.00
High
7.00
H.C. Wainwright
Andres Maldonado
Buy
downgrade
$10 -> $4
AI Analysis
2025-12-19
Reason
H.C. Wainwright
Andres Maldonado
Price Target
$10 -> $4
AI Analysis
2025-12-19
downgrade
Buy
Reason
H.C. Wainwright analyst Andres Maldonado lowered the firm's price target on Werewolf Therapeutics to $4 from $10 and keeps a Buy rating on the shares after the company announced a pipeline and business update. While the shares traded down on the news, the update "underscores tangible progress" toward Werewolf's primary value driver, the "creation of safer, systemically deliverable therapies," the analyst tells investors in a research note.
Wedbush
Outperform -> Neutral
downgrade
$3 -> $1
2025-12-19
Reason
Wedbush
Price Target
$3 -> $1
2025-12-19
downgrade
Outperform -> Neutral
Reason
Wedbush downgraded Werewolf Therapeutics to Neutral from Outperform with a price target of $1, down from $3.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for HOWL
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Valuation Metrics

The current forward P/E ratio for Werewolf Therapeutics Inc (HOWL.O) is -0.49, compared to its 5-year average forward P/E of -3.01. For a more detailed relative valuation and DCF analysis to assess Werewolf Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-3.01
Current PE
-0.49
Overvalued PE
0.03
Undervalued PE
-6.05

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-0.89
Current EV/EBITDA
-0.04
Overvalued EV/EBITDA
1.51
Undervalued EV/EBITDA
-3.30

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
21.30
Current PS
0.00
Overvalued PS
47.14
Undervalued PS
-4.53

Financials

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Frequently Asked Questions

What is Werewolf Therapeutics Inc (HOWL) stock price today?

The current price of HOWL is 0.74 USD — it has increased 0.96

What is Werewolf Therapeutics Inc (HOWL)'s business?

Werewolf Therapeutics, Inc. is a biopharmaceutical company engaged in the development of therapeutics engineered to stimulate the body’s immune system for the treatment of cancer and other immune-mediated conditions. It is leveraging its PREDATOR platform to design conditionally activated molecules that stimulate both adaptive and innate immunity with the goal of addressing the limitations of conventional proinflammatory immune therapies. Its INDUKINE molecules are intended to remain inactive in peripheral tissue yet activate selectively in the tumor microenvironment. The Company’s advanced clinical-stage product candidates, WTX-124 and WTX-330, are systemically delivered, conditionally activated Interleukin-2 (IL-2) and IL-12 INDUKINE molecules for the treatment of solid tumors. It is advancing WTX-124 in multiple tumor types as a single agent and in combination with an immune checkpoint inhibitor. It is advancing WTX-712, WTX-518, and WTX-921 through preclinical development.

What is the price predicton of HOWL Stock?

Wall Street analysts forecast HOWL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for HOWL is4.00 USD with a low forecast of 1.00 USD and a high forecast of 7.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Werewolf Therapeutics Inc (HOWL)'s revenue for the last quarter?

Werewolf Therapeutics Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Werewolf Therapeutics Inc (HOWL)'s earnings per share (EPS) for the last quarter?

Werewolf Therapeutics Inc. EPS for the last quarter amounts to -0.36 USD, decreased -5.26

How many employees does Werewolf Therapeutics Inc (HOWL). have?

Werewolf Therapeutics Inc (HOWL) has 46 emplpoyees as of March 10 2026.

What is Werewolf Therapeutics Inc (HOWL) market cap?

Today HOWL has the market capitalization of 35.57M USD.