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DTIL Overview

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ET
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Intellectia

Loading chart...

High
7.130
Open
6.990
VWAP
6.93
Vol
266.20K
Mkt Cap
179.84M
Low
6.680
Amount
1.84M
EV/EBITDA(TTM)
--
Total Shares
25.80M
EV
99.79M
EV/OCF(TTM)
--
P/S(TTM)
2.56
Precision BioSciences, Inc. is a clinical-stage gene editing company dedicated to improving life (DTIL) with its proprietary ARCUS genome editing platform. Using ARCUS, the Company’s pipeline is comprised of in vivo gene editing candidates designed to deliver cures for a range of genetic and infectious diseases. The ARCUS platform is used to develop in vivo gene editing therapies for gene edits, including gene insertion, elimination, and excision. The Company's in vivo gene editing pipeline programs include PBGENE-HBV, PBGENE-3243, PBGENE-DMD, PBGENE-LIVER, PBGENE-CNS, PBGENE-NVS and iECURE-OTC. PBGENE-HBV is its lead in vivo gene editing program designed to eliminate cccDNA, the key source of replicating hepatitis B virus (HBV) and inactivating integrated HBV DNA in hepatocytes. Its PBGENE-3243 program is a first of its kind potential treatment for m.3243 associated mitochondrial disease. The Company's iECURE-OTC program is developed in partnership with iECURE, Inc.
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Events Timeline

(ET)
2026-05-27
05:20:00
Precision BioSciences Presents PBGENE-HBV Clinical Data at EASL 2026
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2026-05-18 (ET)
2026-05-18
08:10:00
iECURE Reports Positive Results from OTC-HOPE Trial
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2026-05-14 (ET)
2026-05-14
07:20:00
Precision BioSciences Releases New Data on Pbgene-DMD
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2026-05-05 (ET)
2026-05-05
07:30:00
Precision BioSciences Reports Q1 Revenue of $10.8M
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2026-05-05
07:30:00
Precision Expects Cash Runway to Last Through 2028
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2026-04-29 (ET)
2026-04-29
07:20:00
Precision BioSciences Activates PBGENE-DMD Clinical Trial
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2026-04-28 (ET)
2026-04-28
08:20:00
Precision BioSciences PBGENE-DMD Data Accepted for Oral Presentation at ASGCT 2026
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2026-04-24 (ET)
2026-04-24
07:10:00
Precision BioSciences Grants 7,094 Restricted Stock Units to New Employee
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2026-04-15 (ET)
2026-04-15
07:10:00
Precision BioSciences Approved to Expand PBGENE-HBV Clinical Trial
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News

NASDAQ.COM
9.0
05-27NASDAQ.COM
Precision BioSciences Reveals Breakthrough Data in Hepatitis B Treatment
  • Therapeutic Breakthrough: Precision BioSciences' ELIMINATE-B study reveals for the first time that PBGENE-HBV can directly eliminate and inactivate cccDNA in liver biopsies, achieving a 10-fold reduction in cccDNA transcripts post-treatment, marking a significant advancement in hepatitis B therapy.
  • Biomarker Validation: The study validates pgRNA as a reliable biomarker for cccDNA elimination, with all patients showing complete loss of detectable pgRNA after treatment, alongside substantial declines in HBsAg, indicating strong antiviral activity.
  • Safety Management: Across 38 doses administered to 16 patients, PBGENE-HBV demonstrated a manageable safety profile with common infusion-related reactions and no dose-limiting toxicities observed, highlighting the therapy's feasibility for broader application.
  • Future Outlook: Precision BioSciences plans to expand patient enrollment and gather additional biopsy data to strengthen evidence of cccDNA elimination, while preparing for Part 2 of the ELIMINATE-B trial, with updates expected by the end of 2026.
Newsfilter
9.0
05-27Newsfilter
PBGENE-HBV Achieves Breakthrough in Chronic Hepatitis B Treatment
  • Clinical Data Breakthrough: New data demonstrate that PBGENE-HBV achieves a 1-log (10-fold) reduction in cccDNA, providing the first clinical evidence of its efficacy in liver biopsies from chronic hepatitis B patients, marking a significant advancement in the treatment field.
  • Biomarker Confirmation: pgRNA has been established as a biomarker reflecting cccDNA elimination, with 100% of patients achieving pgRNA loss after treatment, showcasing the effectiveness and clear therapeutic window of PBGENE-HBV.
  • Good Safety Profile: Among 38 doses administered, no dose-limiting toxicities were observed, with infusion-related reactions being the most common adverse events, indicating a favorable safety and tolerability profile for PBGENE-HBV.
  • Future Development Directions: Precision plans to expand patient recruitment for the ELIMINATE-B trial, collecting additional biopsy data to support direct targeting and elimination of cccDNA, with further updates expected by the end of 2026 to drive a shift in chronic hepatitis B treatment.
Newsfilter
8.5
05-21Newsfilter
Precision BioSciences to Host Webcast on Hepatitis B Clinical Data
  • Webcast Announcement: Precision BioSciences will host an investor webcast on May 27, 2026, at 8:00 AM EDT to discuss new biopsy and clinical data from the ongoing ELIMINATE-B trial, which is expected to attract attention from investors and Hepatitis B experts, thereby enhancing the company's visibility in the biopharmaceutical sector.
  • ELIMINATE-B Trial Progress: The trial is evaluating PBGENE-HBV as a potential curative treatment for chronic Hepatitis B and has received Fast Track designation from the FDA, indicating its innovative nature and market potential, which could present significant commercial opportunities for the company.
  • Clinical Data Release: The webcast will showcase the latest clinical data and important biopsy results presented at the 2026 European Association for the Study of the Liver Congress, which will support the efficacy of PBGENE-HBV and further bolster investor confidence.
  • Platform Advantages: PBGENE-HBV is the world's first gene editing program targeting the root cause of chronic Hepatitis B, cccDNA, aiming for a viral cure; if successful, it will establish Precision BioSciences as a leader in gene therapy, driving long-term growth.
Newsfilter
9.0
05-13Newsfilter
Preliminary Data on ECUR-506 Treatment for OTC Deficiency
  • Significant Treatment Effects: As of April 20, 2026, 71% of the 7 participants treated with ECUR-506 experienced no hyperammonemic crises (HACs), indicating the therapy's potential to improve quality of life, particularly in neonates with OTC deficiency.
  • Crisis Rate Reduction: Following ECUR-506 treatment, the annualized rate of HACs decreased by approximately 52%, from about 3.12 to 1.49 events per year, providing better survival and developmental opportunities for patients and underscoring the clinical significance of the new therapy.
  • Good Safety Profile: ECUR-506 was generally well tolerated across all dose cohorts, with no unexpected safety events observed, aligning with expected safety characteristics, suggesting optimistic prospects for its application in high-risk populations.
  • Clinical Trial Progress: Preliminary results from the OTC-HOPE trial support continued evaluation of ECUR-506's efficacy, with iECURE planning to further validate its effectiveness in upcoming pivotal trials, offering hope for infants affected by OTC deficiency.
seekingalpha
9.5
05-05seekingalpha
Precision BioSciences Q1 Earnings Report Analysis
  • Earnings Performance: Precision BioSciences reported a Q1 GAAP EPS of -$0.75, missing expectations by $0.09, indicating challenges in profitability that may affect investor confidence.
  • Revenue Growth: The company achieved Q1 revenue of $10.84M, a significant increase from $29K year-over-year, beating market expectations by $6.79M, demonstrating substantial progress in the commercialization of its gene editing technologies.
  • Cash Reserves: As of March 31, 2026, Precision BioSciences holds a cash balance of $125.8M, including cash, cash equivalents, and restricted cash, providing financial stability for future clinical stage gene editing projects.
  • Project Milestones: The company anticipates utilizing its cash reserves to support data milestones for its two wholly owned clinical stage gene editing programs, PBGENE-HBV and PBGENE-DMD, through 2028, reflecting the sustainability of its long-term strategic vision.
seekingalpha
9.5
05-04seekingalpha
Precision BioSciences to Announce Q1 Earnings on May 5
  • Earnings Announcement Schedule: Precision BioSciences is set to release its Q1 2023 earnings report on May 5 before market open, with a consensus EPS estimate of -$0.81, reflecting a 63.3% year-over-year improvement, indicating efforts towards enhancing profitability.
  • Revenue Expectations: Analysts forecast revenue of $4.05 million for the quarter, although the company has only beaten revenue estimates 25% of the time over the past year, suggesting ongoing challenges in revenue growth.
  • Historical Performance Review: Over the past year, Precision BioSciences has exceeded EPS estimates 75% of the time, demonstrating relative stability in earnings forecasts, which may bolster investor confidence ahead of the upcoming report.
  • Market Reaction Anticipation: As the earnings report approaches, investors will closely monitor the company's performance, particularly in the current economic climate, where any results exceeding expectations could positively impact the stock price.
Wall Street analysts forecast DTIL stock price to rise
2 Analyst Rating
Wall Street analysts forecast DTIL stock price to rise
2 Buy
0 Hold
0 Sell
Moderate Buy
Current: 0.000
sliders
Low
30.00
Averages
45.00
High
60.00
Current: 0.000
sliders
Low
30.00
Averages
45.00
High
60.00
JonesResearch
Buy
initiated
$30
AI Analysis
2026-04-16
Reason
JonesResearch
Price Target
$30
AI Analysis
2026-04-16
initiated
Buy
Reason
JonesResearch assumed coverage of Precision BioSciences with a Buy rating and $30 price target. The firm views the company as an \"underappreciated gene editing story.\" The price target is based on PBGENE-HBV in hepatitis B and PBGENE-DMD in Duchenne muscular dystrophy, the analyst tells investors in a research note.

Valuation Metrics

The current forward P/E ratio for Precision BioSciences Inc (DTIL.O) is 11.78, compared to its 5-year average forward P/E of -0.47. For a more detailed relative valuation and DCF analysis to assess Precision BioSciences Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-0.47
Current PE
11.78
Overvalued PE
3.83
Undervalued PE
-4.78

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.33
Current EV/EBITDA
-13.27
Overvalued EV/EBITDA
3.64
Undervalued EV/EBITDA
-2.99

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
6.47
Current PS
13.84
Overvalued PS
13.57
Undervalued PS
-0.63

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Frequently Asked Questions

What is Precision BioSciences Inc (DTIL) stock price today?

The current price of DTIL is 6.97 USD — it has increased 0.72

What is Precision BioSciences Inc (DTIL)'s business?

Precision BioSciences, Inc. is a clinical-stage gene editing company dedicated to improving life (DTIL) with its proprietary ARCUS genome editing platform. Using ARCUS, the Company’s pipeline is comprised of in vivo gene editing candidates designed to deliver cures for a range of genetic and infectious diseases. The ARCUS platform is used to develop in vivo gene editing therapies for gene edits, including gene insertion, elimination, and excision. The Company's in vivo gene editing pipeline programs include PBGENE-HBV, PBGENE-3243, PBGENE-DMD, PBGENE-LIVER, PBGENE-CNS, PBGENE-NVS and iECURE-OTC. PBGENE-HBV is its lead in vivo gene editing program designed to eliminate cccDNA, the key source of replicating hepatitis B virus (HBV) and inactivating integrated HBV DNA in hepatocytes. Its PBGENE-3243 program is a first of its kind potential treatment for m.3243 associated mitochondrial disease. The Company's iECURE-OTC program is developed in partnership with iECURE, Inc.

What is the price predicton of DTIL Stock?

Wall Street analysts forecast DTIL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for DTIL is45.00 USD with a low forecast of 30.00 USD and a high forecast of 60.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Precision BioSciences Inc (DTIL)'s revenue for the last quarter?

Precision BioSciences Inc revenue for the last quarter amounts to 10.84M USD, increased 37272.41

What is Precision BioSciences Inc (DTIL)'s earnings per share (EPS) for the last quarter?

Precision BioSciences Inc. EPS for the last quarter amounts to -0.75 USD, decreased -66.06

How many employees does Precision BioSciences Inc (DTIL). have?

Precision BioSciences Inc (DTIL) has 68 emplpoyees as of May 30 2026.

What is Precision BioSciences Inc (DTIL) market cap?

Today DTIL has the market capitalization of 179.84M USD.