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ALXO Should I Buy

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Intellectia

Should You Buy ALX Oncology Holdings Inc (ALXO) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Hold
Latest Price
2.040
1 Day change
-4.23%
52 Week Range
2.660
Analysis Updated At
2026/03/05
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ALX Oncology Holdings Inc (ALXO) is not a strong buy for a beginner, long-term investor at this time. While the company has promising clinical advancements and an extended cash runway, its financial performance remains weak, with ongoing losses and missed earnings expectations. The technical indicators and trading signals do not suggest a compelling entry point, and the stock's short-term trend indicates potential downside risks. It is advisable to monitor the stock for further developments or better entry points.

Technical Analysis

The MACD histogram is -0.0653, below 0, and negatively expanding, indicating bearish momentum. RSI is neutral at 40.282, and moving averages are converging, showing no clear trend. Key support levels are at 2.066 and 1.915, while resistance levels are at 2.555 and 2.706. The stock's short-term trend suggests a 70% chance of a 3.27% increase in the next day but a -8.83% decrease in the next week.

Options Data

Bullish
Open Interest Put-Call Ratio
Bullish
Option Volume Put-Call Ratio

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
4
Buy
8

Positive Catalysts

  • Significant clinical advancements with Evorpacept and ALX2004, with pivotal study readiness expected by the end of next year.

  • Completion of a $150 million financing round, extending cash runway through the first half of

  • Positive updates from ASPEN-06 gastric cancer and Phase 1b/2 breast cancer trials, validating efficacy and boosting confidence in ongoing trials.

Neutral/Negative Catalysts

  • Q4 2025 financial results showed a net loss of $22.8 million, down 21.65% YoY, and EPS of -$0.42, missing expectations by $0.

  • Stock trend analysis indicates potential short-term downside risks, with an 8.83% decline expected in the next week.

  • No significant hedge fund or insider trading activity to indicate strong confidence in the stock.

Financial Performance

In Q4 2025, ALX Oncology reported a net income loss of $22.85 million, down 21.65% YoY, and an EPS of -0.42, down 22.22% YoY. Revenue and gross margin remained at 0, showing no growth. The company continues to face profitability challenges despite reduced spending.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

Piper Sandler raised the price target from $3 to $4 and maintained an Overweight rating, reflecting optimism about recent updates and clinical progress. However, the stock's current price is significantly below the updated target, indicating a high-risk, high-reward scenario.

Wall Street analysts forecast ALXO stock price to rise
4 Analyst Rating
Wall Street analysts forecast ALXO stock price to rise
3 Buy
1 Hold
0 Sell
Strong Buy
Current: 2.130
sliders
Low
2
Averages
3.33
High
4
Current: 2.130
sliders
Low
2
Averages
3.33
High
4
H.C. Wainwright
Swayampakula Ramakanth
maintain
$2 -> $4
AI Analysis
2026-03-10
New
Reason
H.C. Wainwright
Swayampakula Ramakanth
Price Target
$2 -> $4
AI Analysis
2026-03-10
New
maintain
Reason
H.C. Wainwright analyst Swayampakula Ramakanth raised the firm's price target on ALX Oncology to $4 from $2 and keeps a Buy rating on the shares. The firm says the next major catalyst for the shares is the ALX2004 safety data in the second half of 2026. There is potential for ALX2004 to be different from other EGFR antibody-drug conjugates in terms of safety, the analyst tells investors in a research note.
UBS
Buy
initiated
$6
2026-03-06
New
Reason
UBS
Price Target
$6
2026-03-06
New
initiated
Buy
Reason
UBS initiated coverage of ALX Oncology with a Buy rating and $6 price target. The company has a potential blockbuster program with a CD47 combo currently in Phase II for metastatic breast cancer, the analyst tells investors in a research note. UBS sees ALX reporting a "robust" dataset in mid-2027, demonstrating CD47 inhibitor evorpacept's efficacy in CD47 high and/or HER2+ metastatic breast cancer patients.
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