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ALXO Should I Buy

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Intellectia

Should You Buy ALX Oncology Holdings Inc (ALXO) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Hold
Latest Price
1.750
1 Day change
4.79%
52 Week Range
2.660
Analysis Updated At
2026/04/16
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ALX Oncology Holdings Inc (ALXO) is not a strong buy at this time for a beginner investor with a long-term strategy. While there are some positive catalysts in the pipeline, the company's weak financial performance, insider selling trends, and lack of immediate trading signals suggest it is better to hold off on investing until more favorable conditions arise.

Technical Analysis

The MACD histogram is negative (-0.0308) and contracting, indicating a bearish trend. RSI is at 33.92, which is neutral but leaning towards oversold territory. Moving averages are converging, showing no clear trend. The stock is trading near its support level of 1.638, with resistance at 1.978.

Options Data

Bullish
Open Interest Put-Call Ratio
Bullish
Option Volume Put-Call Ratio

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
5
Buy
6

Positive Catalysts

  • Recent appointment of Jeff Knight as Chief Development and Operating Officer, bringing over 30 years of experience.

  • Promising clinical programs (evorpacept and ALX

  • expected to be significant catalysts within 12-18 months.

  • Analysts have given positive ratings with price targets ranging from $4 to $6, citing potential blockbuster programs in oncology.

Neutral/Negative Catalysts

  • Insiders are selling heavily, with a 2135% increase in selling activity over the last month.

  • Weak financial performance in Q4 2025, with a net income drop of -21.65% YoY and EPS decline of -22.22%.

  • No recent congress trading data or influential figure activity to support the stock.

Financial Performance

The company reported no revenue growth in Q4 2025, with net income dropping to -$22.85 million (-21.65% YoY) and EPS falling to -0.42 (-22.22% YoY). Gross margin remains at 0%.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

Analysts are optimistic about ALXO's long-term potential, with ratings of Overweight and Buy from firms like Wells Fargo, H.C. Wainwright, UBS, and Piper Sandler. Price targets range from $4 to $6, driven by the company's oncology pipeline and potential catalysts in 2026-2027.

Wall Street analysts forecast ALXO stock price to rise
4 Analyst Rating
Wall Street analysts forecast ALXO stock price to rise
3 Buy
1 Hold
0 Sell
Strong Buy
Current: 1.670
sliders
Low
2
Averages
3.33
High
4
Current: 1.670
sliders
Low
2
Averages
3.33
High
4
Wells Fargo
Overweight
initiated
$5
AI Analysis
2026-03-19
Reason
Wells Fargo
Price Target
$5
AI Analysis
2026-03-19
initiated
Overweight
Reason
Wells Fargo initiated coverage of ALX Oncology with an Overweight rating and $5 price target. The firm thinks the near-term update for the evorpacept plus zanidatamab combo in metastatic breast cancer will further validate ALX's CD47-high enrichment strategy. Wells says the update will de-risk the ASPEN-Breast readout in mid-2027. It likes the setup for ALX shares.
H.C. Wainwright
Swayampakula Ramakanth
maintain
$2 -> $4
2026-03-10
Reason
H.C. Wainwright
Swayampakula Ramakanth
Price Target
$2 -> $4
2026-03-10
maintain
Reason
H.C. Wainwright analyst Swayampakula Ramakanth raised the firm's price target on ALX Oncology to $4 from $2 and keeps a Buy rating on the shares. The firm says the next major catalyst for the shares is the ALX2004 safety data in the second half of 2026. There is potential for ALX2004 to be different from other EGFR antibody-drug conjugates in terms of safety, the analyst tells investors in a research note.
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