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ALXO Overview

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ET
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ET
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Intellectia

Loading chart...

High
2.300
Open
2.180
VWAP
2.12
Vol
446.24K
Mkt Cap
268.48M
Low
2.022
Amount
946.40K
EV/EBITDA(TTM)
--
Total Shares
131.61M
EV
80.44M
EV/OCF(TTM)
--
P/S(TTM)
--
ALX Oncology Holdings Inc. is a clinical-stage biotechnology company advancing a pipeline of therapies designed to treat cancer and extend patients’ lives. The Company's lead product candidate, evorpacept, is a CD47 blocking therapeutic that combines a high-affinity CD47 binding domain with an inactivated, proprietary Fc domain. It is engaged in focusing on combining evorpacept with anti-cancer antibodies, antibody drug conjugate (ADCs), and PD-1/PD-L1 immune checkpoint inhibitors. Evorpacept is being evaluated across multiple ongoing clinical trials in a range of cancer indications. Its second product candidate is ALX2004, an epidermal growth factor receptor (EGFR)-targeted ADC. ALX2004 comprises an affinity-tuned EGFR antibody backbone engineered for optimal activity as an ADC, a proprietary topoisomerase I inhibitor payload with enhanced bystander effect, and a linker with enhanced stability.
Show More

Events Timeline

(ET)
2026-02-27
08:10:00
ALX Oncology CEO: Evorpacept Clinical Trial Data Boosts Confidence
select
2026-01-30 (ET)
2026-01-30
08:40:00
ALX Oncology Releases New Data on CD47 Inhibitor with Jazz Pharmaceuticals for Breast Cancer
select
2026-01-08 (ET)
2026-01-08
09:00:00
ALX Oncology Doses First Patient in Phase 2 ASPEN-09 Breast Trial
select
2025-12-07 (ET)
2025-12-07
13:40:00
ALX Oncology Presents Positive Data from Evorpacept Trial
select
2025-11-07 (ET)
2025-11-07
08:23:20
ALX Oncology projects sufficient cash reserves to last until the first quarter of 2027.
select
2025-11-07
08:22:57
ALX Oncology Announces Q3 Earnings Per Share of 41 Cents, Exceeding Consensus Estimate of 37 Cents
select

News

seekingalpha
9.5
02-27seekingalpha
ALX Oncology Q4 2025 Earnings Call Highlights
  • Executive Appointment: ALX Oncology announced the appointment of Dr. Barbara Klencke as Chief Medical Officer, succeeding her interim role since September 2025, with management highlighting the importance of this appointment during a critical inflection point for the company.
  • Clinical Progress: The company reported significant advancements in the clinical development of evorpacept and ALX2004, having treated over 750 patients, with plans to advance these programs to pivotal study readiness by the end of next year, demonstrating strong execution and stable timelines.
  • Successful Financing: ALX Oncology completed a $150 million financing round, strengthening its balance sheet and enabling the company to deliver more meaningful data in its ongoing clinical programs, with expectations to support operations through the first half of 2028.
  • Financial Performance: The company reported a GAAP net loss of $22.8 million for Q4 2025, or $0.42 per share, a decrease from $29.2 million in the prior year period, reflecting reduced spending following pipeline prioritization efforts.
seekingalpha
9.5
02-27seekingalpha
ALX Oncology Q4 Earnings Miss Expectations, Shares Rise on Offering
  • Earnings Report Disappointment: ALX Oncology reported a Q4 GAAP EPS of -$0.42, missing expectations by $0.06, indicating challenges in profitability that may undermine market confidence in its future earnings potential.
  • Net Loss Impact: The company recorded a net loss of $22.85 million, reflecting ongoing pressures from R&D and operational expenditures, which could affect its liquidity and future investment capabilities.
  • Capital Market Activity: Despite the disappointing earnings, ALX Oncology announced the pricing of an underwritten offering, resulting in a nearly 15% increase in share price, indicating a positive market response to its financing strategy that may provide essential funding support.
  • Investor Engagement: ALX Oncology's presentation at the 44th Annual J.P. Morgan Healthcare Conference garnered investor interest, highlighting the company's efforts to seek new capital and strategic partnerships, potentially laying the groundwork for future growth.
Newsfilter
9.5
02-27Newsfilter
ALX Oncology Reports Clinical Progress and Financial Update
  • Clinical Trial Progress: ALX Oncology's CD47 inhibitor Evorpacept is on track following strong execution in 2025, with multiple significant data sets and milestones anticipated in the next 12 to 18 months, showcasing the company's potential in cancer treatment.
  • Biomarker Validation: Data from the ASPEN-06 gastric cancer trial and Phase 1b/2 breast cancer trial independently validate the correlation between CD47 overexpression and Evorpacept efficacy, potentially providing durable benefits for HER2-positive cancer patients and enhancing confidence in ongoing clinical trials.
  • Successful Financing: The company completed a $150 million registered stock offering, extending its cash runway through the first half of 2028, ensuring the continued advancement of key clinical programs and demonstrating strong performance in the capital markets.
  • Executive Appointment: Barbara Klencke, M.D. has been appointed as Chief Medical Officer on a permanent basis, expected to drive further progress in clinical development, reflecting the company's commitment to its leadership team.
Newsfilter
1.0
02-19Newsfilter
ALX Oncology to Participate in Multiple Biotech Summits
  • Summit Participation: ALX Oncology will hold one-on-one meetings at the Wells Fargo Executive Biotech Summit on February 24-25, 2026, in Lake Tahoe, aimed at deepening investor engagement and enhancing the company's visibility in the biotech sector.
  • Healthcare Conference: The company will present at the TD Cowen 46th Annual Health Care Conference on March 3, 2026, at 9:10 AM EST in Boston, which is expected to attract significant attention from both industry insiders and investors, further driving interest in its clinical pipeline.
  • Webcast Availability: The presentation at the TD Cowen conference will be available via webcast on ALX Oncology's investor section, with replays accessible for up to 90 days post-event, ensuring that investors who cannot attend live can still access critical information.
  • Pipeline Progress: ALX Oncology's lead candidate, evorpacept, is being evaluated in multiple ongoing clinical trials across various cancer indications, demonstrating potential as a cornerstone therapy for immuno-oncology, thereby solidifying the company's strategic position in the biotech landscape.
seekingalpha
8.5
02-04seekingalpha
ALX Oncology Shares Surge 10% After Major VC Purchase
  • Share Purchase Announcement: Venture capital firm venBio Capital purchased nearly 3.2 million shares of ALX Oncology at $1.57 per share on February 2, totaling $5 million, significantly boosting market confidence in the company's future prospects.
  • Management Connection: venBio's Managing Partner Corey Goodman serves as the chair of ALX Oncology's board and is a co-founder, which may further solidify investor trust in the company's strategic direction due to this close relationship.
  • Market Reaction: Following the announcement, ALX Oncology's shares surged approximately 10% in after-hours trading, reflecting optimistic market sentiment regarding the company's outlook, particularly in the context of its HER2/CD47 breast cancer treatment opportunities.
  • Future Potential: ALX Oncology anticipates entering a $2 billion to $4 billion HER2/CD47 breast cancer market by 2025, which presents a substantial revenue growth opportunity and is likely to attract further investor interest.
NASDAQ.COM
8.5
02-02NASDAQ.COM
ALX Oncology Announces Pricing of Underwritten Offering
  • Offering Size: ALX Oncology announced an underwritten offering of 76.98 million shares at $1.57 each, expecting gross proceeds of approximately $150 million, which will fund the continued clinical development of Evorpacept and ALX2004, indicating strong commitment to future R&D.
  • Pre-Funded Warrants: The company also issued 18.57 million pre-funded warrants at $1.569 each, reflecting flexibility in its financing structure aimed at attracting more investor participation in the offering.
  • Market Performance: Over the past year, ALXO's stock traded between $0.4040 and $2.27, indicating high volatility, while closing the latest trading day up 10.83% at $1.74, suggesting a positive market reaction to the offering news.
  • After-Hours Trading: Despite a 1.72% decline in after-hours trading to $1.71, the overall implementation of the financing plan is viewed as a significant step in the company's strategic development, potentially providing necessary funding for upcoming clinical trials.
Wall Street analysts forecast ALXO stock price to rise
4 Analyst Rating
Wall Street analysts forecast ALXO stock price to rise
3 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
2.00
Averages
3.33
High
4.00
Current: 0.000
sliders
Low
2.00
Averages
3.33
High
4.00
H.C. Wainwright
Swayampakula Ramakanth
maintain
$2 -> $4
AI Analysis
2026-03-10
New
Reason
H.C. Wainwright
Swayampakula Ramakanth
Price Target
$2 -> $4
AI Analysis
2026-03-10
New
maintain
Reason
H.C. Wainwright analyst Swayampakula Ramakanth raised the firm's price target on ALX Oncology to $4 from $2 and keeps a Buy rating on the shares. The firm says the next major catalyst for the shares is the ALX2004 safety data in the second half of 2026. There is potential for ALX2004 to be different from other EGFR antibody-drug conjugates in terms of safety, the analyst tells investors in a research note.
UBS
Buy
initiated
$6
2026-03-06
New
Reason
UBS
Price Target
$6
2026-03-06
New
initiated
Buy
Reason
UBS initiated coverage of ALX Oncology with a Buy rating and $6 price target. The company has a potential blockbuster program with a CD47 combo currently in Phase II for metastatic breast cancer, the analyst tells investors in a research note. UBS sees ALX reporting a "robust" dataset in mid-2027, demonstrating CD47 inhibitor evorpacept's efficacy in CD47 high and/or HER2+ metastatic breast cancer patients.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ALXO
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Valuation Metrics

The current forward P/E ratio for ALX Oncology Holdings Inc (ALXO.O) is -0.92, compared to its 5-year average forward P/E of -6.54. For a more detailed relative valuation and DCF analysis to assess ALX Oncology Holdings Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-6.54
Current PE
-0.92
Overvalued PE
3.39
Undervalued PE
-16.46

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-3.98
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
3.48
Undervalued EV/EBITDA
-11.45

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
957.35
Current PS
0.00
Overvalued PS
5056.99
Undervalued PS
-3142.28

Financials

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Frequently Asked Questions

What is ALX Oncology Holdings Inc (ALXO) stock price today?

The current price of ALXO is 2.04 USD — it has decreased -4.23

What is ALX Oncology Holdings Inc (ALXO)'s business?

ALX Oncology Holdings Inc. is a clinical-stage biotechnology company advancing a pipeline of therapies designed to treat cancer and extend patients’ lives. The Company's lead product candidate, evorpacept, is a CD47 blocking therapeutic that combines a high-affinity CD47 binding domain with an inactivated, proprietary Fc domain. It is engaged in focusing on combining evorpacept with anti-cancer antibodies, antibody drug conjugate (ADCs), and PD-1/PD-L1 immune checkpoint inhibitors. Evorpacept is being evaluated across multiple ongoing clinical trials in a range of cancer indications. Its second product candidate is ALX2004, an epidermal growth factor receptor (EGFR)-targeted ADC. ALX2004 comprises an affinity-tuned EGFR antibody backbone engineered for optimal activity as an ADC, a proprietary topoisomerase I inhibitor payload with enhanced bystander effect, and a linker with enhanced stability.

What is the price predicton of ALXO Stock?

Wall Street analysts forecast ALXO stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ALXO is3.33 USD with a low forecast of 2.00 USD and a high forecast of 4.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is ALX Oncology Holdings Inc (ALXO)'s revenue for the last quarter?

ALX Oncology Holdings Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is ALX Oncology Holdings Inc (ALXO)'s earnings per share (EPS) for the last quarter?

ALX Oncology Holdings Inc. EPS for the last quarter amounts to -0.42 USD, decreased -22.22

How many employees does ALX Oncology Holdings Inc (ALXO). have?

ALX Oncology Holdings Inc (ALXO) has 80 emplpoyees as of March 11 2026.

What is ALX Oncology Holdings Inc (ALXO) market cap?

Today ALXO has the market capitalization of 268.48M USD.