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ALXO Overview

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ET
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ET
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Intellectia

Loading chart...

High
2.105
Open
1.890
VWAP
1.98
Vol
998.76K
Mkt Cap
279.89M
Low
1.760
Amount
1.98M
EV/EBITDA(TTM)
--
Total Shares
134.56M
EV
148.07M
EV/OCF(TTM)
--
P/S(TTM)
--
ALX Oncology Holdings Inc. is a clinical-stage biotechnology company advancing a pipeline of therapies designed to treat cancer and extend patients’ lives. The Company's lead product candidate, evorpacept, is a CD47 blocking therapeutic that combines a high-affinity CD47 binding domain with an inactivated, proprietary Fc domain. It is engaged in focusing on combining evorpacept with anti-cancer antibodies, antibody drug conjugate (ADCs), and PD-1/PD-L1 immune checkpoint inhibitors. Evorpacept is being evaluated across multiple ongoing clinical trials in a range of cancer indications. Its second product candidate is ALX2004, an epidermal growth factor receptor (EGFR)-targeted ADC. ALX2004 comprises an affinity-tuned EGFR antibody backbone engineered for optimal activity as an ADC, a proprietary topoisomerase I inhibitor payload with enhanced bystander effect, and a linker with enhanced stability.
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Events Timeline

(ET)
2026-04-13
09:00:00
ALX Oncology Appoints Jeff Knight as Chief Development and Operating Officer
select
2026-02-27 (ET)
2026-02-27
08:10:00
ALX Oncology CEO: Evorpacept Clinical Trial Data Boosts Confidence
select
2026-01-30 (ET)
2026-01-30
08:40:00
ALX Oncology Releases New Data on CD47 Inhibitor with Jazz Pharmaceuticals for Breast Cancer
select
2026-01-08 (ET)
2026-01-08
09:00:00
ALX Oncology Doses First Patient in Phase 2 ASPEN-09 Breast Trial
select
2025-12-07 (ET)
2025-12-07
13:40:00
ALX Oncology Presents Positive Data from Evorpacept Trial
select

News

seekingalpha
9.5
05-08seekingalpha
PinnedALX Oncology Q1 Earnings Beat Expectations
  • Earnings Performance: ALX Oncology reported a Q1 GAAP EPS of -$0.17, beating expectations by $0.02, indicating some improvement in financial management that may boost investor confidence.
  • Cash Reserves: As of March 31, 2026, the company had $169.1 million in cash, cash equivalents, and investments, sufficient to fund operations through the first half of 2028, reflecting strong liquidity management.
  • Clinical Trial Readiness: ALX Oncology aims to complete pivotal trial readiness by the end of 2026 with an expanded ASPEN-09 study, showcasing proactive advancements in R&D that could lay the groundwork for future product launches.
  • Financing Plans: The company is pursuing $150 million in financing to support its clinical trials and operations, demonstrating ALX Oncology's confidence in future growth and strategic positioning in the market.
Newsfilter
8.5
05-08Newsfilter
PinnedALX Oncology Presents Promising Evorpacept Data at ESMO Breast Cancer 2026
  • Clinical Trial Results: At the 2026 ESMO Congress, ALX Oncology presented data showing that all patients with high CD47 expression receiving evorpacept in combination with zanidatamab experienced durable responses, reinforcing the CD47-selection hypothesis and potentially derisking the path forward in HER2-positive breast cancer.
  • Trial Progress: The ongoing Phase 2 ASPEN-09-Breast trial is on track to provide topline data for 80 patients in mid-2027, combining trastuzumab and chemotherapy, aimed at offering new treatment options for HER2-positive patients and addressing the urgent market need for novel therapies.
  • Leadership Enhancement: ALX Oncology appointed Jeff Knight as Chief Development and Operating Officer, leveraging over 30 years of experience in the biopharmaceutical industry to strengthen the company's development capabilities and operational infrastructure to support upcoming milestones.
  • Improved Financial Position: As of March 31, 2026, ALX reported cash and cash equivalents of $169.1 million, which is expected to fund operations through the first half of 2028, demonstrating the company's financial stability as it advances its clinical programs.
seekingalpha
9.5
05-09seekingalpha
ALX Oncology Q1 2026 Earnings Call Insights
  • Clinical Data Highlights: At the ESMO Breast 2026 conference in Munich, ALX Oncology reported that all confirmed HER2-positive and CD47 high-expressing patients achieved a response, including one complete response, indicating that CD47 expression is a key predictive biomarker for enhancing durable clinical responses.
  • Market Opportunity Assessment: The company estimates approximately 20,000 HER2-positive and CD47-overexpressing patients in the U.S. and five major European markets and Japan, representing a market opportunity of $2 billion to $4 billion, showcasing the potential commercial value of its products.
  • Trial Progress Update: ALX Oncology is advancing the ASPEN-09 study, aiming to enroll up to 120 patients with a primary endpoint of response rate in CD47-overexpressing patients, with initial data from approximately 80 patients expected by mid-2027, further validating its treatment strategy.
  • Leadership Enhancement: The company appointed Jeff Knight as Chief Development and Chief Operating Officer, further strengthening the leadership team to ensure the smooth progress of clinical trials and the implementation of the overall corporate strategy.
Newsfilter
5.0
04-17Newsfilter
ALX Oncology Grants Stock Options to New COO
  • Stock Option Grant: On April 16, 2026, ALX Oncology granted 800,000 stock options to new COO Jeff Knight at an exercise price of $1.68 per share, aligning with Nasdaq rules to incentivize his employment and drive business growth.
  • Vesting Schedule: The stock options vest 25% on the one-year anniversary of April 13, 2026, with the remainder vesting monthly, ensuring Knight's continued service and motivation within the company.
  • Pipeline Advancement: ALX Oncology is advancing its cancer treatment pipeline, with lead candidate Evorpacept showing potential as a cornerstone therapy in immuno-oncology, currently evaluated in multiple clinical trials, which is expected to positively impact future growth.
  • New Drug Development: The second candidate, ALX2004, is undergoing a Phase 1 dose-escalation trial for EGFR-expressing solid tumors, and successful outcomes could further enrich the company's product line and enhance market competitiveness.
Newsfilter
5.0
04-13Newsfilter
ALX Oncology Appoints New Chief Development Officer
  • Executive Appointment: ALX Oncology appointed Jeff Knight as Chief Development and Operating Officer effective April 13, 2026, bringing over 30 years of biopharmaceutical experience, previously at Crinetics Pharmaceuticals, where he oversaw clinical development and corporate operations, expected to drive success in clinical projects.
  • Clinical Program Outlook: The evorpacept and ALX2004 clinical programs are anticipated to serve as significant catalysts in the next 12 to 18 months, with Knight's leadership expected to enhance the company's development capabilities and operational infrastructure, ensuring high-quality execution and achievement of upcoming milestones.
  • Industry Expertise: Knight has held senior leadership roles at renowned biopharmaceutical companies, including Amgen and Genentech, where he gained extensive experience in oncology clinical development and regulatory affairs, providing robust support for ALX Oncology's strategic growth.
  • Company Vision: Knight expressed that ALX Oncology is entering a critical growth phase with multiple opportunities to advance its pipeline, and he is excited about the company's clinical programs and data, looking forward to collaborating with the team to ensure strategic development and operational excellence.
seekingalpha
9.5
02-27seekingalpha
ALX Oncology Q4 2025 Earnings Call Highlights
  • Executive Appointment: ALX Oncology announced the appointment of Dr. Barbara Klencke as Chief Medical Officer, succeeding her interim role since September 2025, with management highlighting the importance of this appointment during a critical inflection point for the company.
  • Clinical Progress: The company reported significant advancements in the clinical development of evorpacept and ALX2004, having treated over 750 patients, with plans to advance these programs to pivotal study readiness by the end of next year, demonstrating strong execution and stable timelines.
  • Successful Financing: ALX Oncology completed a $150 million financing round, strengthening its balance sheet and enabling the company to deliver more meaningful data in its ongoing clinical programs, with expectations to support operations through the first half of 2028.
  • Financial Performance: The company reported a GAAP net loss of $22.8 million for Q4 2025, or $0.42 per share, a decrease from $29.2 million in the prior year period, reflecting reduced spending following pipeline prioritization efforts.
Wall Street analysts forecast ALXO stock price to rise
4 Analyst Rating
Wall Street analysts forecast ALXO stock price to rise
3 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
2.00
Averages
3.33
High
4.00
Current: 0.000
sliders
Low
2.00
Averages
3.33
High
4.00
Wells Fargo
Overweight
initiated
$5
AI Analysis
2026-03-19
Reason
Wells Fargo
Price Target
$5
AI Analysis
2026-03-19
initiated
Overweight
Reason
Wells Fargo initiated coverage of ALX Oncology with an Overweight rating and $5 price target. The firm thinks the near-term update for the evorpacept plus zanidatamab combo in metastatic breast cancer will further validate ALX's CD47-high enrichment strategy. Wells says the update will de-risk the ASPEN-Breast readout in mid-2027. It likes the setup for ALX shares.
H.C. Wainwright
Swayampakula Ramakanth
maintain
$2 -> $4
2026-03-10
Reason
H.C. Wainwright
Swayampakula Ramakanth
Price Target
$2 -> $4
2026-03-10
maintain
Reason
H.C. Wainwright analyst Swayampakula Ramakanth raised the firm's price target on ALX Oncology to $4 from $2 and keeps a Buy rating on the shares. The firm says the next major catalyst for the shares is the ALX2004 safety data in the second half of 2026. There is potential for ALX2004 to be different from other EGFR antibody-drug conjugates in terms of safety, the analyst tells investors in a research note.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ALXO
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Valuation Metrics

The current forward P/E ratio for ALX Oncology Holdings Inc (ALXO.O) is 0.00, compared to its 5-year average forward P/E of -5.62. For a more detailed relative valuation and DCF analysis to assess ALX Oncology Holdings Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-5.62
Current PE
0.00
Overvalued PE
3.14
Undervalued PE
-14.38

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-3.26
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
3.17
Undervalued EV/EBITDA
-9.69

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
535.18
Current PS
0.00
Overvalued PS
3535.46
Undervalued PS
-2465.10

Financials

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Frequently Asked Questions

What is ALX Oncology Holdings Inc (ALXO) stock price today?

The current price of ALXO is 2.08 USD — it has increased 11.23

What is ALX Oncology Holdings Inc (ALXO)'s business?

ALX Oncology Holdings Inc. is a clinical-stage biotechnology company advancing a pipeline of therapies designed to treat cancer and extend patients’ lives. The Company's lead product candidate, evorpacept, is a CD47 blocking therapeutic that combines a high-affinity CD47 binding domain with an inactivated, proprietary Fc domain. It is engaged in focusing on combining evorpacept with anti-cancer antibodies, antibody drug conjugate (ADCs), and PD-1/PD-L1 immune checkpoint inhibitors. Evorpacept is being evaluated across multiple ongoing clinical trials in a range of cancer indications. Its second product candidate is ALX2004, an epidermal growth factor receptor (EGFR)-targeted ADC. ALX2004 comprises an affinity-tuned EGFR antibody backbone engineered for optimal activity as an ADC, a proprietary topoisomerase I inhibitor payload with enhanced bystander effect, and a linker with enhanced stability.

What is the price predicton of ALXO Stock?

Wall Street analysts forecast ALXO stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ALXO is3.33 USD with a low forecast of 2.00 USD and a high forecast of 4.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is ALX Oncology Holdings Inc (ALXO)'s revenue for the last quarter?

ALX Oncology Holdings Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is ALX Oncology Holdings Inc (ALXO)'s earnings per share (EPS) for the last quarter?

ALX Oncology Holdings Inc. EPS for the last quarter amounts to -0.17 USD, decreased -70.69

How many employees does ALX Oncology Holdings Inc (ALXO). have?

ALX Oncology Holdings Inc (ALXO) has 43 emplpoyees as of May 11 2026.

What is ALX Oncology Holdings Inc (ALXO) market cap?

Today ALXO has the market capitalization of 279.89M USD.