ZCMD, ABCL, VOR, IXHL, OVID, BFRG Surge in After-Hours Trading Due to Clinical Progress and Recent Developments
Biotech Stocks Surge: Several biotech and healthcare stocks experienced significant after-hours gains on October 1, driven by technical momentum and recent clinical updates, despite the absence of new filings or press releases.
Zhongchao Inc. and AbCellera Biologics: Zhongchao Inc. saw a 14.04% increase after hours, while AbCellera Biologics rose 11.41%, both benefiting from prior trial data and analyst commentary rather than new announcements.
Vor Biopharma and Incannex Healthcare: Vor Biopharma rebounded 9.53% after a previous drop, and Incannex Healthcare gained 6.48%, with both companies relying on earlier clinical trial results to influence trading.
Ovid Therapeutics and Bullfrog AI Holdings: Ovid Therapeutics shares rose 8.03% following a positive earnings report, while Bullfrog AI Holdings advanced 3.44% after announcing an expansion of its sales and marketing team.
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Ovid Therapeutics Advances KCC2 Oral Activator OV4071 Clinical Trial Plans
- Successful Safety Evaluation: The Phase 1 study of OV350 in 16 healthy participants demonstrated a good safety profile with no treatment-related serious adverse events, indicating its potential for future clinical applications in KCC2 activator development.
- Pharmacokinetics as Expected: The pharmacokinetic results for OV350 were as predicted, supporting further research into KCC2 activators, particularly the clinical trial plans for OV4071.
- Clinical Trial Plans: Ovid plans to submit a regulatory application for a Phase 1/1b clinical trial of OV4071 in Q1 2026, targeting psychosis associated with Parkinson's disease and Lewy body dementia, addressing a high unmet need.
- Investment in Drug Development: Ovid is prioritizing resources to accelerate the development of oral KCC2 activators, reflecting the company's commitment to new mechanism drugs that could open new avenues in the treatment of neuropsychiatric disorders.

Ovid Therapeutics Appoints Dr. Petra Kaufmann as Chief Medical Officer to Advance CNS Drug Development
- New Chief Medical Officer: Ovid Therapeutics has appointed Dr. Petra Kaufmann as Chief Medical Officer, responsible for guiding clinical, medical, and regulatory strategies to advance the company’s pipeline of potential best- and first-in-class therapeutic candidates for neuronal imbalance.
- Extensive Drug Development Experience: Dr. Kaufmann brings a wealth of experience in CNS therapeutics, having served as CMO at Vigil Neuroscience and Novartis Gene Therapies, where she played a key role in the global approval of Zolgensma®, showcasing her expertise in developing drugs for complex neurological conditions.
- Patient-Focused R&D Philosophy: Dr. Kaufmann emphasizes a patient-focused development approach, committed to advancing OV329 and the KCC2 portfolio through rigorous scientific mechanisms, ensuring that each program is guided by sound clinical principles and a deep understanding of patient needs.
- Strategic Leadership Team Enhancement: Ovid's President Meg Alexander stated that Dr. Kaufmann's appointment will strengthen the company’s R&D organization, driving innovation and enhancing market competitiveness in the field of neurological therapeutics.








